Mediation of acetylcholine and substance P induced contractions by myosin light chain phosphorylation in feline colonic smooth muscle

To determine the role of myosin light chain phosphorylation in feline colonic smooth muscle contraction. Colonic tissue was obtained from eight 12- to 24-month-old cats. Colonic longitudinal smooth muscle strips were attached to isometric force transducers for measurements of isometric stress. Myosi...

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Veröffentlicht in:	American journal of veterinary research 2002-05, Vol.63 (5), p.695-702
Hauptverfasser:	Washabau, Robert J, Holt, David E, Brockman, Daniel J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcholine - antagonists & inhibitors Acetylcholine - pharmacology Acetylcholine - physiology Animals Azepines - pharmacology Calcium - metabolism Calcium - physiology Calmodulin - metabolism Calmodulin - pharmacology Cats - physiology Colon - drug effects Colon - physiology Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Female In Vitro Techniques Isometric Contraction - drug effects Isometric Contraction - physiology Male Muscle, Smooth - drug effects Muscle, Smooth - physiology Myosin Light Chains - metabolism Myosin Light Chains - physiology Phosphorylation Substance P - antagonists & inhibitors Substance P - pharmacology Substance P - physiology Sulfonamides - pharmacology
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