Prefrontal Broadband Noise, Working Memory, and Genetic Risk for Schizophrenia
OBJECTIVE: It has been suggested that increased variability of prefrontal physiological responses may represent a fundamental mechanism underlying frontal lobe deficits in schizophrenia. Increased response variability ("noise") is thought to result from impaired phase resetting of stimulus...
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| Veröffentlicht in: | The American journal of psychiatry 2004-03, Vol.161 (3), p.490-500 |
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| container_title | The American journal of psychiatry |
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| creator | Winterer, Georg Coppola, Richard Goldberg, Terry E. Egan, Michael F. Jones, Douglas W. Sanchez, Carmen E. Weinberger, Daniel R. |
| description | OBJECTIVE: It has been suggested that increased variability of prefrontal physiological responses may represent a fundamental mechanism underlying frontal lobe deficits in schizophrenia. Increased response variability ("noise") is thought to result from impaired phase resetting of stimulus-induced dynamic changes of ongoing rhythmic oscillations (field potentials) generated in the apical dendrites of pyramidal neurons. In the present study, the authors explored whether this particular physiological abnormality predicts working memory performance and is related to the genetic risk for schizophrenia. METHOD: Prefrontal response variability of discrete frequency components was investigated across a broad frequency range (0.5-45.0 Hz) during processing of an oddball paradigm in patients with schizophrenia (N=66), their clinically unaffected siblings (N=115), and healthy comparison subjects (N=89). RESULTS: As hypothesized, prefrontal noise was negatively correlated with working memory performance across all subjects. In addition, it was observed that prefrontal noise possesses trait characteristics and is strongly associated with genetic risk for schizophrenia. CONCLUSIONS: Frontal lobe-related cognitive function depends on the ability to synchronize cortical pyramidal neurons, which is in part genetically controlled. Increased prefrontal "noise" is an intermediate phenotype related to genetic susceptibility for schizophrenia. |
| doi_str_mv | 10.1176/appi.ajp.161.3.490 |
| format | Article |
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Increased response variability ("noise") is thought to result from impaired phase resetting of stimulus-induced dynamic changes of ongoing rhythmic oscillations (field potentials) generated in the apical dendrites of pyramidal neurons. In the present study, the authors explored whether this particular physiological abnormality predicts working memory performance and is related to the genetic risk for schizophrenia. METHOD: Prefrontal response variability of discrete frequency components was investigated across a broad frequency range (0.5-45.0 Hz) during processing of an oddball paradigm in patients with schizophrenia (N=66), their clinically unaffected siblings (N=115), and healthy comparison subjects (N=89). RESULTS: As hypothesized, prefrontal noise was negatively correlated with working memory performance across all subjects. In addition, it was observed that prefrontal noise possesses trait characteristics and is strongly associated with genetic risk for schizophrenia. CONCLUSIONS: Frontal lobe-related cognitive function depends on the ability to synchronize cortical pyramidal neurons, which is in part genetically controlled. Increased prefrontal "noise" is an intermediate phenotype related to genetic susceptibility for schizophrenia.</description><identifier>ISSN: 0002-953X</identifier><identifier>EISSN: 1535-7228</identifier><identifier>DOI: 10.1176/appi.ajp.161.3.490</identifier><identifier>PMID: 14992975</identifier><identifier>CODEN: AJPSAO</identifier><language>eng</language><publisher>Washington, DC: American Psychiatric Publishing</publisher><subject>Adult ; Adult and adolescent clinical studies ; Arousal - physiology ; Assessment ; Attention - physiology ; Auditory stimulation ; Biological and medical sciences ; Brain Mapping ; Brain mechanisms ; Cerebral Cortex - physiopathology ; Cognition & reasoning ; Electroencephalography ; Evoked Potentials - genetics ; Evoked Potentials - physiology ; Female ; Genetic Predisposition to Disease - genetics ; Genetic susceptibility ; Genetics ; Humans ; Male ; Medical sciences ; Memory, Short-Term - physiology ; Middle Aged ; Models, Genetic ; Neuropsychological Tests ; Noise ; Physiological reactivity ; Pitch Discrimination - physiology ; Prefrontal Cortex - physiopathology ; Psychology. Psychoanalysis. Psychiatry ; Psychometrics ; Psychopathology. Psychiatry ; Psychoses ; Pyramidal Cells - physiology ; Reference Values ; Risk Assessment ; Schizophrenia ; Schizophrenia - diagnosis ; Schizophrenia - genetics ; Schizophrenia - physiopathology ; Schizophrenic Psychology ; Schizotypal Personality Disorder - diagnosis ; Schizotypal Personality Disorder - genetics ; Schizotypal Personality Disorder - physiopathology ; Schizotypal Personality Disorder - psychology ; Siblings - psychology ; Signal Processing, Computer-Assisted ; Working memory</subject><ispartof>The American journal of psychiatry, 2004-03, Vol.161 (3), p.490-500</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright American Psychiatric Association Mar 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a425t-bc2627461816f86f5d8eebd4ae56b83eaee60a46302dca74c211b49c544321dc3</citedby><cites>FETCH-LOGICAL-a425t-bc2627461816f86f5d8eebd4ae56b83eaee60a46302dca74c211b49c544321dc3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://psychiatryonline.org/doi/epdf/10.1176/appi.ajp.161.3.490$$EPDF$$P50$$Gappi$$H</linktopdf><linktohtml>$$Uhttps://psychiatryonline.org/doi/full/10.1176/appi.ajp.161.3.490$$EHTML$$P50$$Gappi$$H</linktohtml><link.rule.ids>314,778,782,2844,21609,21610,21611,27907,27908,30983,77545,77550</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15546456$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14992975$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Winterer, Georg</creatorcontrib><creatorcontrib>Coppola, Richard</creatorcontrib><creatorcontrib>Goldberg, Terry E.</creatorcontrib><creatorcontrib>Egan, Michael F.</creatorcontrib><creatorcontrib>Jones, Douglas W.</creatorcontrib><creatorcontrib>Sanchez, Carmen E.</creatorcontrib><creatorcontrib>Weinberger, Daniel R.</creatorcontrib><title>Prefrontal Broadband Noise, Working Memory, and Genetic Risk for Schizophrenia</title><title>The American journal of psychiatry</title><addtitle>Am J Psychiatry</addtitle><description>OBJECTIVE: It has been suggested that increased variability of prefrontal physiological responses may represent a fundamental mechanism underlying frontal lobe deficits in schizophrenia. Increased response variability ("noise") is thought to result from impaired phase resetting of stimulus-induced dynamic changes of ongoing rhythmic oscillations (field potentials) generated in the apical dendrites of pyramidal neurons. In the present study, the authors explored whether this particular physiological abnormality predicts working memory performance and is related to the genetic risk for schizophrenia. METHOD: Prefrontal response variability of discrete frequency components was investigated across a broad frequency range (0.5-45.0 Hz) during processing of an oddball paradigm in patients with schizophrenia (N=66), their clinically unaffected siblings (N=115), and healthy comparison subjects (N=89). RESULTS: As hypothesized, prefrontal noise was negatively correlated with working memory performance across all subjects. In addition, it was observed that prefrontal noise possesses trait characteristics and is strongly associated with genetic risk for schizophrenia. CONCLUSIONS: Frontal lobe-related cognitive function depends on the ability to synchronize cortical pyramidal neurons, which is in part genetically controlled. Increased prefrontal "noise" is an intermediate phenotype related to genetic susceptibility for schizophrenia.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Arousal - physiology</subject><subject>Assessment</subject><subject>Attention - physiology</subject><subject>Auditory stimulation</subject><subject>Biological and medical sciences</subject><subject>Brain Mapping</subject><subject>Brain mechanisms</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Cognition & reasoning</subject><subject>Electroencephalography</subject><subject>Evoked Potentials - genetics</subject><subject>Evoked Potentials - physiology</subject><subject>Female</subject><subject>Genetic Predisposition to Disease - genetics</subject><subject>Genetic susceptibility</subject><subject>Genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Memory, Short-Term - physiology</subject><subject>Middle Aged</subject><subject>Models, Genetic</subject><subject>Neuropsychological Tests</subject><subject>Noise</subject><subject>Physiological reactivity</subject><subject>Pitch Discrimination - physiology</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychometrics</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Pyramidal Cells - physiology</subject><subject>Reference Values</subject><subject>Risk Assessment</subject><subject>Schizophrenia</subject><subject>Schizophrenia - diagnosis</subject><subject>Schizophrenia - genetics</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenic Psychology</subject><subject>Schizotypal Personality Disorder - diagnosis</subject><subject>Schizotypal Personality Disorder - genetics</subject><subject>Schizotypal Personality Disorder - physiopathology</subject><subject>Schizotypal Personality Disorder - psychology</subject><subject>Siblings - psychology</subject><subject>Signal Processing, Computer-Assisted</subject><subject>Working memory</subject><issn>0002-953X</issn><issn>1535-7228</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>7QJ</sourceid><recordid>eNqF0U1v1DAQBmALgehS-AMcUIQEpyb1t50jVNAilYL4ENysiTOh3mbjYO8eyq_H2121Ug9wsiw_M2P7JeQ5ow1jRh_DPIcGlnPDNGtEI1v6gCyYEqo2nNuHZEEp5XWrxM8D8iTnZdlSYfhjcsBk2_LWqAW5-JxwSHFaw1i9TRH6Dqa-uogh41H1I6arMP2qPuIqpuujant0ihOug6--hHxVDTFVX_1l-BPny4RTgKfk0QBjxmf79ZB8f__u28lZff7p9MPJm_MaJFfruvNccyM1s0wPVg-qt4hdLwGV7qxAQNQUpBaU9x6M9JyxTrZeSSk46704JK93fecUf28wr90qZI_jCBPGTXaGaWupUf-FqkhtrCnw5T24jJs0lUc4zqm0XLesIL5DPsWcy8-5OYUVpGvHqNtm4raZuJKJK5k44UompejFvvOmW2F_V7IPoYBXewDZwzgkmHzId04pqaXSxR3v3M2Q2-v9Y_RfA0mk9A</recordid><startdate>20040301</startdate><enddate>20040301</enddate><creator>Winterer, Georg</creator><creator>Coppola, Richard</creator><creator>Goldberg, Terry E.</creator><creator>Egan, Michael F.</creator><creator>Jones, Douglas W.</creator><creator>Sanchez, Carmen E.</creator><creator>Weinberger, Daniel R.</creator><general>American Psychiatric Publishing</general><general>American Psychiatric Association</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7QJ</scope><scope>7X8</scope></search><sort><creationdate>20040301</creationdate><title>Prefrontal Broadband Noise, Working Memory, and Genetic Risk for Schizophrenia</title><author>Winterer, Georg ; Coppola, Richard ; Goldberg, Terry E. ; Egan, Michael F. ; Jones, Douglas W. ; Sanchez, Carmen E. ; Weinberger, Daniel R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a425t-bc2627461816f86f5d8eebd4ae56b83eaee60a46302dca74c211b49c544321dc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Arousal - physiology</topic><topic>Assessment</topic><topic>Attention - physiology</topic><topic>Auditory stimulation</topic><topic>Biological and medical sciences</topic><topic>Brain Mapping</topic><topic>Brain mechanisms</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Cognition & reasoning</topic><topic>Electroencephalography</topic><topic>Evoked Potentials - genetics</topic><topic>Evoked Potentials - physiology</topic><topic>Female</topic><topic>Genetic Predisposition to Disease - genetics</topic><topic>Genetic susceptibility</topic><topic>Genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Memory, Short-Term - physiology</topic><topic>Middle Aged</topic><topic>Models, Genetic</topic><topic>Neuropsychological Tests</topic><topic>Noise</topic><topic>Physiological reactivity</topic><topic>Pitch Discrimination - physiology</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychometrics</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Pyramidal Cells - physiology</topic><topic>Reference Values</topic><topic>Risk Assessment</topic><topic>Schizophrenia</topic><topic>Schizophrenia - diagnosis</topic><topic>Schizophrenia - genetics</topic><topic>Schizophrenia - physiopathology</topic><topic>Schizophrenic Psychology</topic><topic>Schizotypal Personality Disorder - diagnosis</topic><topic>Schizotypal Personality Disorder - genetics</topic><topic>Schizotypal Personality Disorder - physiopathology</topic><topic>Schizotypal Personality Disorder - psychology</topic><topic>Siblings - psychology</topic><topic>Signal Processing, Computer-Assisted</topic><topic>Working memory</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Winterer, Georg</creatorcontrib><creatorcontrib>Coppola, Richard</creatorcontrib><creatorcontrib>Goldberg, Terry E.</creatorcontrib><creatorcontrib>Egan, Michael F.</creatorcontrib><creatorcontrib>Jones, Douglas W.</creatorcontrib><creatorcontrib>Sanchez, Carmen E.</creatorcontrib><creatorcontrib>Weinberger, Daniel R.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Applied Social Sciences Index & Abstracts (ASSIA)</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Winterer, Georg</au><au>Coppola, Richard</au><au>Goldberg, Terry E.</au><au>Egan, Michael F.</au><au>Jones, Douglas W.</au><au>Sanchez, Carmen E.</au><au>Weinberger, Daniel R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prefrontal Broadband Noise, Working Memory, and Genetic Risk for Schizophrenia</atitle><jtitle>The American journal of psychiatry</jtitle><addtitle>Am J Psychiatry</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>161</volume><issue>3</issue><spage>490</spage><epage>500</epage><pages>490-500</pages><issn>0002-953X</issn><eissn>1535-7228</eissn><coden>AJPSAO</coden><abstract>OBJECTIVE: It has been suggested that increased variability of prefrontal physiological responses may represent a fundamental mechanism underlying frontal lobe deficits in schizophrenia. Increased response variability ("noise") is thought to result from impaired phase resetting of stimulus-induced dynamic changes of ongoing rhythmic oscillations (field potentials) generated in the apical dendrites of pyramidal neurons. In the present study, the authors explored whether this particular physiological abnormality predicts working memory performance and is related to the genetic risk for schizophrenia. METHOD: Prefrontal response variability of discrete frequency components was investigated across a broad frequency range (0.5-45.0 Hz) during processing of an oddball paradigm in patients with schizophrenia (N=66), their clinically unaffected siblings (N=115), and healthy comparison subjects (N=89). RESULTS: As hypothesized, prefrontal noise was negatively correlated with working memory performance across all subjects. In addition, it was observed that prefrontal noise possesses trait characteristics and is strongly associated with genetic risk for schizophrenia. CONCLUSIONS: Frontal lobe-related cognitive function depends on the ability to synchronize cortical pyramidal neurons, which is in part genetically controlled. Increased prefrontal "noise" is an intermediate phenotype related to genetic susceptibility for schizophrenia.</abstract><cop>Washington, DC</cop><pub>American Psychiatric Publishing</pub><pmid>14992975</pmid><doi>10.1176/appi.ajp.161.3.490</doi><tpages>11</tpages></addata></record> |
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| ispartof | The American journal of psychiatry, 2004-03, Vol.161 (3), p.490-500 |
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| source | MEDLINE; American Psychiatric Publishing Journals (1997-Present); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Applied Social Sciences Index & Abstracts (ASSIA) |
| subjects | Adult Adult and adolescent clinical studies Arousal - physiology Assessment Attention - physiology Auditory stimulation Biological and medical sciences Brain Mapping Brain mechanisms Cerebral Cortex - physiopathology Cognition & reasoning Electroencephalography Evoked Potentials - genetics Evoked Potentials - physiology Female Genetic Predisposition to Disease - genetics Genetic susceptibility Genetics Humans Male Medical sciences Memory, Short-Term - physiology Middle Aged Models, Genetic Neuropsychological Tests Noise Physiological reactivity Pitch Discrimination - physiology Prefrontal Cortex - physiopathology Psychology. Psychoanalysis. Psychiatry Psychometrics Psychopathology. Psychiatry Psychoses Pyramidal Cells - physiology Reference Values Risk Assessment Schizophrenia Schizophrenia - diagnosis Schizophrenia - genetics Schizophrenia - physiopathology Schizophrenic Psychology Schizotypal Personality Disorder - diagnosis Schizotypal Personality Disorder - genetics Schizotypal Personality Disorder - physiopathology Schizotypal Personality Disorder - psychology Siblings - psychology Signal Processing, Computer-Assisted Working memory |
| title | Prefrontal Broadband Noise, Working Memory, and Genetic Risk for Schizophrenia |
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