A High Degree of Aneuploidy, Loss of p53 Gene, and Low Soluble p53 Protein Serum Levels Are Detected in Ulcerative Colitis Patients

A High Degree of Aneuploidy, Loss of p53 Gene, and Low Soluble p53 Protein Serum Levels Are Detected in Ulcerative Colitis Patients

PURPOSE: METHODS:Ulcerative colitis patients (n = 42) and healthy controls (n = 37) participated in the study. All participants were histopathologically and medically diagnosed. The stage of ulcerative colitis patients was stratified according to increasing risk factors for the development of colore...

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Veröffentlicht in:Diseases of the colon & rectum 2004-03, Vol.47 (3), p.304-313
Hauptverfasser: Rosman-Urbach, Maya, Niv, Yaron, Birk, Yehudith, Smirnoff, Patricia, Zusman, Igor, Morgenstern, Sara, Schwartz, Betty
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Aged
Aneuploidy
Biological and medical sciences
Biopsy
Case-Control Studies
Chromosome aberrations
Chromosomes, Human, Pair 17
Colitis, Ulcerative - blood
Colitis, Ulcerative - genetics
Colorectal Neoplasms - blood
Colorectal Neoplasms - genetics
Diploidy
Female
Gastroenterology. Liver. Pancreas. Abdomen
Genes, p53
Genomic Instability
Humans
In Situ Hybridization, Fluorescence
Intestinal Mucosa - pathology
Loss of Heterozygosity
Male
Medical genetics
Medical sciences
Middle Aged
Other diseases. Semiology
Risk Factors
Stomach. Duodenum. Small intestine. Colon. Rectum. Anus
Tumor Suppressor Protein p53 - blood
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Zusammenfassung:PURPOSE: METHODS:Ulcerative colitis patients (n = 42) and healthy controls (n = 37) participated in the study. All participants were histopathologically and medically diagnosed. The stage of ulcerative colitis patients was stratified according to increasing risk factors for the development of colorectal cancerleft-sided colitis, pancolitis, sclerosing cholangitis, and dysplasia-associated lesions or masses. Changes in centromere number of chromosome 17 alone or in association with changes in copy number of the p53 gene were analyzed in colon tissue biopsies by fluorescence in situ hybridization. Serum p53 level was determined in blood samples by immunoprecipitation followed by separation using high-pressure liquid chromatography. RESULTS: CONCLUSIONS:
ISSN:0012-3706
1530-0358
DOI:10.1007/s10350-003-0048-z