Efficient Chemoenzymatic Synthesis of O-Linked Sialyl Oligosaccharides

The tumor associated Tn (GalNAcα(1-1)-Thr/Ser)- and T (Galβ(1-3)-GalNAcα(1-1)Thr/Ser)-antigens and their sialylated derivatives are present on the surface of many cancer cells. Preparative synthesis of these sialylated T- and Tn-structures has been achieved mainly from a chemical synthetic approach...

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Veröffentlicht in:	Journal of the American Chemical Society 2002-05, Vol.124 (20), p.5739-5746
Hauptverfasser:	Blixt, Ola, Allin, Kirk, Pereira, Laura, Datta, Arun, Paulson, James C
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical, structural and metabolic biochemistry Animals Antigens, Tumor-Associated, Carbohydrate - biosynthesis Antigens, Tumor-Associated, Carbohydrate - chemistry Biological and medical sciences Carbohydrate Sequence Carbohydrates Chickens Fundamental and applied biological sciences. Psychology Holosides Molecular Sequence Data Mucins - biosynthesis Mucins - chemical synthesis Mucins - chemistry Other biological molecules Recombinant Proteins - biosynthesis Recombinant Proteins - chemistry Recombinant Proteins - genetics Recombinant Proteins - metabolism Sialyltransferases - biosynthesis Sialyltransferases - chemistry Sialyltransferases - genetics Sialyltransferases - metabolism Substrate Specificity Swine
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