RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis
It is known that mammalian rpS3 functions as a DNA repair endonuclease and ribosomal protein S3. It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent...
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| Veröffentlicht in: | FEBS letters 2004-02, Vol.560 (1), p.81-85 |
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| creator | Jang, Chang-Young Lee, Jae Yung Kim, Joon |
| description | It is known that mammalian rpS3 functions as a DNA repair endonuclease and ribosomal protein S3. It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent protein (GFP)-rpS3 is changed to the nuclear membrane when lymphocytic cells undergo rpS3-induced apoptosis. Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis. Deletion analysis reveals that the two functions of rpS3, DNA repair and apoptosis, use independent functional domains. |
| doi_str_mv | 10.1016/S0014-5793(04)00074-2 |
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It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent protein (GFP)-rpS3 is changed to the nuclear membrane when lymphocytic cells undergo rpS3-induced apoptosis. Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis. 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It was also observed that several ribosomal proteins or DNA repair enzymes are related to apoptosis. We report here a third function of rpS3, induction of apoptosis. The localization of green fluorescent protein (GFP)-rpS3 is changed to the nuclear membrane when lymphocytic cells undergo rpS3-induced apoptosis. Transient expression of GFP-rpS3 activates caspase-8/caspase-3 and sensitizes cytokine-induced apoptosis. Deletion analysis reveals that the two functions of rpS3, DNA repair and apoptosis, use independent functional domains.</description><subject>Animals</subject><subject>Antibodies, Monoclonal - metabolism</subject><subject>Apoptosis</subject><subject>Caspases - metabolism</subject><subject>Cell Line, Tumor</subject><subject>Cytokine</subject><subject>Deoxyribonuclease I - metabolism</subject><subject>DNA Repair</subject><subject>Enzyme Activation</subject><subject>Epitopes</subject><subject>Gene Deletion</subject><subject>Green Fluorescent Proteins</subject><subject>Humans</subject><subject>Jurkat Cells</subject><subject>Luminescent Proteins</subject><subject>Lymphocyte</subject><subject>Mice</subject><subject>Plasmacytoma</subject><subject>Protein Structure, Tertiary</subject><subject>Recombinant Proteins - metabolism</subject><subject>Ribosomal Proteins - chemistry</subject><subject>Ribosomal Proteins - genetics</subject><subject>Ribosomal Proteins - metabolism</subject><subject>rpS3</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkF1P2zAUhq0JNArsJ2zyFWISGcexndhXCEr5kNCQgF1bjn0qeUrjzG6L-PdL2mq7hCtbPs95_eoh5CuDHwxYdf4MwEQha81PQXwHgFoU5ScyYarmBReV2iOTf8gBOcz59wAxxfRncsCEVgqgnJDHp_6Zn1FLr39e0oS9DYli52O3ci3ajNR2nqbQxBwXtqV9iksM3RkNmYZuHds1-uFCbR_7ZcwhH5P9uW0zftmdR-TXzexlelc8PN7eTy8fCidrKAvmrAAlG4-ukZZXXjnLea2F4FqDLctSCOXQ47wZ-lfOc-GdtEprpnQDnh-Rk23u0OjPCvPSLEJ22La2w7jKpmaVqmTN3gVZDVLJqhxAuQVdijknnJs-hYVNb4aBGZWbjXIz-jQgzEa5Gfe-7T5YNQv0_7d2jgfgbgu8hhbfPpZqbmZX5WYyDkBsnseoi20UDmrXAZPJLmA3iAoJ3dL4GN5p-xdg06MG</recordid><startdate>20040227</startdate><enddate>20040227</enddate><creator>Jang, Chang-Young</creator><creator>Lee, Jae Yung</creator><creator>Kim, Joon</creator><general>Elsevier B.V</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>7X8</scope></search><sort><creationdate>20040227</creationdate><title>RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis</title><author>Jang, Chang-Young ; Lee, Jae Yung ; Kim, Joon</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5702-1ca4085bdecb5a36d8ca3379443990a222448cedefb5796cd34dc5a899189b0d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Animals</topic><topic>Antibodies, Monoclonal - metabolism</topic><topic>Apoptosis</topic><topic>Caspases - metabolism</topic><topic>Cell Line, Tumor</topic><topic>Cytokine</topic><topic>Deoxyribonuclease I - metabolism</topic><topic>DNA Repair</topic><topic>Enzyme Activation</topic><topic>Epitopes</topic><topic>Gene Deletion</topic><topic>Green Fluorescent Proteins</topic><topic>Humans</topic><topic>Jurkat Cells</topic><topic>Luminescent Proteins</topic><topic>Lymphocyte</topic><topic>Mice</topic><topic>Plasmacytoma</topic><topic>Protein Structure, Tertiary</topic><topic>Recombinant Proteins - metabolism</topic><topic>Ribosomal Proteins - chemistry</topic><topic>Ribosomal Proteins - genetics</topic><topic>Ribosomal Proteins - metabolism</topic><topic>rpS3</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Chang-Young</creatorcontrib><creatorcontrib>Lee, Jae Yung</creatorcontrib><creatorcontrib>Kim, Joon</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Chang-Young</au><au>Lee, Jae Yung</au><au>Kim, Joon</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2004-02-27</date><risdate>2004</risdate><volume>560</volume><issue>1</issue><spage>81</spage><epage>85</epage><pages>81-85</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>It is known that mammalian rpS3 functions as a DNA repair endonuclease and ribosomal protein S3. 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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Animals Antibodies, Monoclonal - metabolism Apoptosis Caspases - metabolism Cell Line, Tumor Cytokine Deoxyribonuclease I - metabolism DNA Repair Enzyme Activation Epitopes Gene Deletion Green Fluorescent Proteins Humans Jurkat Cells Luminescent Proteins Lymphocyte Mice Plasmacytoma Protein Structure, Tertiary Recombinant Proteins - metabolism Ribosomal Proteins - chemistry Ribosomal Proteins - genetics Ribosomal Proteins - metabolism rpS3 |
| title | RpS3, a DNA repair endonuclease and ribosomal protein, is involved in apoptosis |
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