Contrast-Enhanced Sonography of Autoimmune Pancreatitis: Comparison With Pathologic Findings
We evaluated the vascularity of autoimmune pancreatitis lesions on contrast-enhanced harmonic gray scale sonographic images in comparison with the pathologic findings. Six patients with autoimmune pancreatitis were examined. All patients held their breath from 20 to 50 seconds after the injection of...
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| Veröffentlicht in: | Journal of ultrasound in medicine 2004-02, Vol.23 (2), p.199-206 |
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| creator | Numata, Kazushi Ozawa, Yutaka Kobayashi, Noritoshi Kubota, Toru Akinori, Nozawa Nakatani, Yukio Sugimori, Kazuya Imada, Toshio Tanaka, Katsuaki |
| description | We evaluated the vascularity of autoimmune pancreatitis lesions on contrast-enhanced harmonic gray scale sonographic images in comparison with the pathologic findings.
Six patients with autoimmune pancreatitis were examined. All patients held their breath from 20 to 50 seconds after the injection of a contrast agent while the vascularity of the lesion was examined by contrast-enhanced harmonic gray scale sonography (early phase), and lesion enhancement was monitored at about 90 seconds after the injection while the patients held their breath for a few seconds (delayed phase). We then compared the vascularity on the contrast-enhanced harmonic gray scale sonographic images with the pathologic findings (fibrosis and inflammation) in all lesions. The vascularity of 3 of the 6 lesions was also evaluated by contrast-enhanced harmonic gray scale sonography before and after treatment with corticosteroids.
The autoimmune pancreatitis lesions exhibited mild (n = 1), moderate (n = 3), or marked (n = 2) enhancement throughout almost the entire lesions in both the early and delayed phases. The grade of lesion vascularity on the contrast-enhanced harmonic gray scale sonographic images correlated with the pathologic grade of inflammation and inversely correlated with the grade of fibrosis associated with autoimmune pancreatitis. The vascularity of all 3 lesions had decreased on the contrast-enhanced harmonic gray scale sonographic images after steroid therapy.
Contrast-enhanced harmonic gray scale sonography may be useful for evaluating the vascularity of autoimmune pancreatitis lesions and the therapeutic efficacy of steroid therapy. |
| doi_str_mv | 10.7863/jum.2004.23.2.199 |
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Six patients with autoimmune pancreatitis were examined. All patients held their breath from 20 to 50 seconds after the injection of a contrast agent while the vascularity of the lesion was examined by contrast-enhanced harmonic gray scale sonography (early phase), and lesion enhancement was monitored at about 90 seconds after the injection while the patients held their breath for a few seconds (delayed phase). We then compared the vascularity on the contrast-enhanced harmonic gray scale sonographic images with the pathologic findings (fibrosis and inflammation) in all lesions. The vascularity of 3 of the 6 lesions was also evaluated by contrast-enhanced harmonic gray scale sonography before and after treatment with corticosteroids.
The autoimmune pancreatitis lesions exhibited mild (n = 1), moderate (n = 3), or marked (n = 2) enhancement throughout almost the entire lesions in both the early and delayed phases. The grade of lesion vascularity on the contrast-enhanced harmonic gray scale sonographic images correlated with the pathologic grade of inflammation and inversely correlated with the grade of fibrosis associated with autoimmune pancreatitis. The vascularity of all 3 lesions had decreased on the contrast-enhanced harmonic gray scale sonographic images after steroid therapy.
Contrast-enhanced harmonic gray scale sonography may be useful for evaluating the vascularity of autoimmune pancreatitis lesions and the therapeutic efficacy of steroid therapy.</description><identifier>ISSN: 0278-4297</identifier><identifier>EISSN: 1550-9613</identifier><identifier>DOI: 10.7863/jum.2004.23.2.199</identifier><identifier>PMID: 14992356</identifier><identifier>CODEN: JUMEDA</identifier><language>eng</language><publisher>Laurel, MD: Am inst Ulrrasound Med</publisher><subject>Aged ; Autoimmune Diseases - diagnostic imaging ; Autoimmune Diseases - pathology ; Biological and medical sciences ; Contrast Media ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Male ; Medical sciences ; Middle Aged ; Other diseases. Semiology ; Pancreatitis - diagnostic imaging ; Pancreatitis - pathology ; Polysaccharides ; Ultrasonography</subject><ispartof>Journal of ultrasound in medicine, 2004-02, Vol.23 (2), p.199-206</ispartof><rights>2004 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c309t-564c5da7f7f165bc83535de53cb75cfae1adfb6ecbe5c5b99b1ac4e26a4e01633</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15459648$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14992356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Numata, Kazushi</creatorcontrib><creatorcontrib>Ozawa, Yutaka</creatorcontrib><creatorcontrib>Kobayashi, Noritoshi</creatorcontrib><creatorcontrib>Kubota, Toru</creatorcontrib><creatorcontrib>Akinori, Nozawa</creatorcontrib><creatorcontrib>Nakatani, Yukio</creatorcontrib><creatorcontrib>Sugimori, Kazuya</creatorcontrib><creatorcontrib>Imada, Toshio</creatorcontrib><creatorcontrib>Tanaka, Katsuaki</creatorcontrib><title>Contrast-Enhanced Sonography of Autoimmune Pancreatitis: Comparison With Pathologic Findings</title><title>Journal of ultrasound in medicine</title><addtitle>J Ultrasound Med</addtitle><description>We evaluated the vascularity of autoimmune pancreatitis lesions on contrast-enhanced harmonic gray scale sonographic images in comparison with the pathologic findings.
Six patients with autoimmune pancreatitis were examined. All patients held their breath from 20 to 50 seconds after the injection of a contrast agent while the vascularity of the lesion was examined by contrast-enhanced harmonic gray scale sonography (early phase), and lesion enhancement was monitored at about 90 seconds after the injection while the patients held their breath for a few seconds (delayed phase). We then compared the vascularity on the contrast-enhanced harmonic gray scale sonographic images with the pathologic findings (fibrosis and inflammation) in all lesions. The vascularity of 3 of the 6 lesions was also evaluated by contrast-enhanced harmonic gray scale sonography before and after treatment with corticosteroids.
The autoimmune pancreatitis lesions exhibited mild (n = 1), moderate (n = 3), or marked (n = 2) enhancement throughout almost the entire lesions in both the early and delayed phases. The grade of lesion vascularity on the contrast-enhanced harmonic gray scale sonographic images correlated with the pathologic grade of inflammation and inversely correlated with the grade of fibrosis associated with autoimmune pancreatitis. The vascularity of all 3 lesions had decreased on the contrast-enhanced harmonic gray scale sonographic images after steroid therapy.
Contrast-enhanced harmonic gray scale sonography may be useful for evaluating the vascularity of autoimmune pancreatitis lesions and the therapeutic efficacy of steroid therapy.</description><subject>Aged</subject><subject>Autoimmune Diseases - diagnostic imaging</subject><subject>Autoimmune Diseases - pathology</subject><subject>Biological and medical sciences</subject><subject>Contrast Media</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Other diseases. Semiology</subject><subject>Pancreatitis - diagnostic imaging</subject><subject>Pancreatitis - pathology</subject><subject>Polysaccharides</subject><subject>Ultrasonography</subject><issn>0278-4297</issn><issn>1550-9613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9L5DAYhoMoOrr7B3iRXvTWmt9tvMng6IKwC6vsZSGkaTqNtMmYpAzz3xtxcE7f4X3e94MHgEsEq7rh5PZtnioMIa0wqXCFhDgCC8QYLAVH5BgsIK6bkmJRn4HzGN8gxBDV9BScISoEJowvwP-ldymomMoHNyinTVf89c6vg9oMu8L3xf2cvJ2m2ZniT86DUckmG--KpZ82KtjoXfHPpiGnafCjX1tdrKzrrFvHH-CkV2M0P_f3AryuHl6WT-Xz78dfy_vnUhMoUsk41axTdV_3iLNWN4QR1hlGdFsz3SuDVNe33OjWMM1aIVqkNDWYK2og4oRcgJuv3U3w77OJSU42ajOOyhk_R1kj3nCKaAbRF6iDjzGYXm6CnVTYSQTlp1KZlcpPpRITiWVWmjtX-_G5nUx3aOwdZuB6D6io1diHrMnGA8coE5w2B26w62Frg5FxUuOYZ5HcbrffDz8AViyO4g</recordid><startdate>20040201</startdate><enddate>20040201</enddate><creator>Numata, Kazushi</creator><creator>Ozawa, Yutaka</creator><creator>Kobayashi, Noritoshi</creator><creator>Kubota, Toru</creator><creator>Akinori, Nozawa</creator><creator>Nakatani, Yukio</creator><creator>Sugimori, Kazuya</creator><creator>Imada, Toshio</creator><creator>Tanaka, Katsuaki</creator><general>Am inst Ulrrasound Med</general><general>American Institute of Ultrasound in Medicine</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20040201</creationdate><title>Contrast-Enhanced Sonography of Autoimmune Pancreatitis: Comparison With Pathologic Findings</title><author>Numata, Kazushi ; Ozawa, Yutaka ; Kobayashi, Noritoshi ; Kubota, Toru ; Akinori, Nozawa ; Nakatani, Yukio ; Sugimori, Kazuya ; Imada, Toshio ; Tanaka, Katsuaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c309t-564c5da7f7f165bc83535de53cb75cfae1adfb6ecbe5c5b99b1ac4e26a4e01633</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Autoimmune Diseases - diagnostic imaging</topic><topic>Autoimmune Diseases - pathology</topic><topic>Biological and medical sciences</topic><topic>Contrast Media</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Other diseases. Semiology</topic><topic>Pancreatitis - diagnostic imaging</topic><topic>Pancreatitis - pathology</topic><topic>Polysaccharides</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Numata, Kazushi</creatorcontrib><creatorcontrib>Ozawa, Yutaka</creatorcontrib><creatorcontrib>Kobayashi, Noritoshi</creatorcontrib><creatorcontrib>Kubota, Toru</creatorcontrib><creatorcontrib>Akinori, Nozawa</creatorcontrib><creatorcontrib>Nakatani, Yukio</creatorcontrib><creatorcontrib>Sugimori, Kazuya</creatorcontrib><creatorcontrib>Imada, Toshio</creatorcontrib><creatorcontrib>Tanaka, Katsuaki</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ultrasound in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Numata, Kazushi</au><au>Ozawa, Yutaka</au><au>Kobayashi, Noritoshi</au><au>Kubota, Toru</au><au>Akinori, Nozawa</au><au>Nakatani, Yukio</au><au>Sugimori, Kazuya</au><au>Imada, Toshio</au><au>Tanaka, Katsuaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Contrast-Enhanced Sonography of Autoimmune Pancreatitis: Comparison With Pathologic Findings</atitle><jtitle>Journal of ultrasound in medicine</jtitle><addtitle>J Ultrasound Med</addtitle><date>2004-02-01</date><risdate>2004</risdate><volume>23</volume><issue>2</issue><spage>199</spage><epage>206</epage><pages>199-206</pages><issn>0278-4297</issn><eissn>1550-9613</eissn><coden>JUMEDA</coden><abstract>We evaluated the vascularity of autoimmune pancreatitis lesions on contrast-enhanced harmonic gray scale sonographic images in comparison with the pathologic findings.
Six patients with autoimmune pancreatitis were examined. All patients held their breath from 20 to 50 seconds after the injection of a contrast agent while the vascularity of the lesion was examined by contrast-enhanced harmonic gray scale sonography (early phase), and lesion enhancement was monitored at about 90 seconds after the injection while the patients held their breath for a few seconds (delayed phase). We then compared the vascularity on the contrast-enhanced harmonic gray scale sonographic images with the pathologic findings (fibrosis and inflammation) in all lesions. The vascularity of 3 of the 6 lesions was also evaluated by contrast-enhanced harmonic gray scale sonography before and after treatment with corticosteroids.
The autoimmune pancreatitis lesions exhibited mild (n = 1), moderate (n = 3), or marked (n = 2) enhancement throughout almost the entire lesions in both the early and delayed phases. The grade of lesion vascularity on the contrast-enhanced harmonic gray scale sonographic images correlated with the pathologic grade of inflammation and inversely correlated with the grade of fibrosis associated with autoimmune pancreatitis. The vascularity of all 3 lesions had decreased on the contrast-enhanced harmonic gray scale sonographic images after steroid therapy.
Contrast-enhanced harmonic gray scale sonography may be useful for evaluating the vascularity of autoimmune pancreatitis lesions and the therapeutic efficacy of steroid therapy.</abstract><cop>Laurel, MD</cop><pub>Am inst Ulrrasound Med</pub><pmid>14992356</pmid><doi>10.7863/jum.2004.23.2.199</doi><tpages>8</tpages></addata></record> |
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| subjects | Aged Autoimmune Diseases - diagnostic imaging Autoimmune Diseases - pathology Biological and medical sciences Contrast Media Gastroenterology. Liver. Pancreas. Abdomen Humans Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences Middle Aged Other diseases. Semiology Pancreatitis - diagnostic imaging Pancreatitis - pathology Polysaccharides Ultrasonography |
| title | Contrast-Enhanced Sonography of Autoimmune Pancreatitis: Comparison With Pathologic Findings |
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