Chymase inhibitors may prevent postoperative adhesion formation
Objective: To clarify the role of chymase produced from mast cells in adhesion formation, we measured chymase activity level and investigated the preventive effect of a chymase inhibitor, Suc-Val-Pro-Phe p(OPh) 2, on the postoperative adhesion formation. Design: Prospective randomized study using a...
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| Veröffentlicht in: | Fertility and sterility 2002-05, Vol.77 (5), p.1044-1048 |
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| container_title | Fertility and sterility |
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| creator | Okamoto, Yukiko Takai, Shinji Yamada, Mayumi Miyazaki, Mizuo |
| description | Objective: To clarify the role of chymase produced from mast cells in adhesion formation, we measured chymase activity level and investigated the preventive effect of a chymase inhibitor, Suc-Val-Pro-Phe
p(OPh)
2, on the postoperative adhesion formation.
Design: Prospective randomized study using a surgical model for adhesion formation.
Setting: Clean hamsters in an academic research environment.
Animal(s): Sixty-seven female Syrian hamsters.
Intervention(s): Hamsters were given a lesion, produced by uterus scraping, and the chymase inhibitor (10 μM) or placebo was injected into the abdomen. Chymase activities in uteri were measured 3 days after the operation, and the scores of adhesion formations were assessed at 2 weeks.
Main Outcome Measure(s): Measurement of chymase activity and scoring of adhesion formation were performed.
Result(s): A significant increase of chymase activity in the injured uterus reduced by treatment with the chymase inhibitor. The scores of adhesion formations in the chymase inhibitor-treated group were significantly decreased in comparison with those in the placebo-treated group.
Conclusion(s): Chymase contained in mast cells plays an important role in adhesion formation, and a chymase inhibitor may be a useful drug for prevention of adhesion formation. |
| doi_str_mv | 10.1016/S0015-0282(02)03083-2 |
| format | Article |
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p(OPh)
2, on the postoperative adhesion formation.
Design: Prospective randomized study using a surgical model for adhesion formation.
Setting: Clean hamsters in an academic research environment.
Animal(s): Sixty-seven female Syrian hamsters.
Intervention(s): Hamsters were given a lesion, produced by uterus scraping, and the chymase inhibitor (10 μM) or placebo was injected into the abdomen. Chymase activities in uteri were measured 3 days after the operation, and the scores of adhesion formations were assessed at 2 weeks.
Main Outcome Measure(s): Measurement of chymase activity and scoring of adhesion formation were performed.
Result(s): A significant increase of chymase activity in the injured uterus reduced by treatment with the chymase inhibitor. The scores of adhesion formations in the chymase inhibitor-treated group were significantly decreased in comparison with those in the placebo-treated group.
Conclusion(s): Chymase contained in mast cells plays an important role in adhesion formation, and a chymase inhibitor may be a useful drug for prevention of adhesion formation.</description><identifier>ISSN: 0015-0282</identifier><identifier>EISSN: 1556-5653</identifier><identifier>DOI: 10.1016/S0015-0282(02)03083-2</identifier><identifier>PMID: 12009365</identifier><identifier>CODEN: FESTAS</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Adhesion ; Animals ; Biological and medical sciences ; chymase ; chymase inhibitor ; Chymases ; Cricetinae ; Enzyme Inhibitors - pharmacology ; Female ; Genital system. Reproduction ; Gynecologic Surgical Procedures - adverse effects ; mast cells ; Medical sciences ; Mesocricetus ; Oligopeptides - pharmacology ; Peritoneal Diseases - pathology ; Peritoneal Diseases - prevention & control ; Pharmacology. Drug treatments ; Serine Endopeptidases - metabolism ; Tissue Adhesions - pathology ; Tissue Adhesions - prevention & control ; Uterus - enzymology ; Uterus - surgery</subject><ispartof>Fertility and sterility, 2002-05, Vol.77 (5), p.1044-1048</ispartof><rights>2002 American Society for Reproductive Medicine</rights><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c504t-90bc8a13d8d29b1442eb8102b8cd6b6c4f4ec75b5d8ea0b47e12fe01894744293</citedby><cites>FETCH-LOGICAL-c504t-90bc8a13d8d29b1442eb8102b8cd6b6c4f4ec75b5d8ea0b47e12fe01894744293</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0015028202030832$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13677024$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12009365$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okamoto, Yukiko</creatorcontrib><creatorcontrib>Takai, Shinji</creatorcontrib><creatorcontrib>Yamada, Mayumi</creatorcontrib><creatorcontrib>Miyazaki, Mizuo</creatorcontrib><title>Chymase inhibitors may prevent postoperative adhesion formation</title><title>Fertility and sterility</title><addtitle>Fertil Steril</addtitle><description>Objective: To clarify the role of chymase produced from mast cells in adhesion formation, we measured chymase activity level and investigated the preventive effect of a chymase inhibitor, Suc-Val-Pro-Phe
p(OPh)
2, on the postoperative adhesion formation.
Design: Prospective randomized study using a surgical model for adhesion formation.
Setting: Clean hamsters in an academic research environment.
Animal(s): Sixty-seven female Syrian hamsters.
Intervention(s): Hamsters were given a lesion, produced by uterus scraping, and the chymase inhibitor (10 μM) or placebo was injected into the abdomen. Chymase activities in uteri were measured 3 days after the operation, and the scores of adhesion formations were assessed at 2 weeks.
Main Outcome Measure(s): Measurement of chymase activity and scoring of adhesion formation were performed.
Result(s): A significant increase of chymase activity in the injured uterus reduced by treatment with the chymase inhibitor. The scores of adhesion formations in the chymase inhibitor-treated group were significantly decreased in comparison with those in the placebo-treated group.
Conclusion(s): Chymase contained in mast cells plays an important role in adhesion formation, and a chymase inhibitor may be a useful drug for prevention of adhesion formation.</description><subject>Adhesion</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>chymase</subject><subject>chymase inhibitor</subject><subject>Chymases</subject><subject>Cricetinae</subject><subject>Enzyme Inhibitors - pharmacology</subject><subject>Female</subject><subject>Genital system. Reproduction</subject><subject>Gynecologic Surgical Procedures - adverse effects</subject><subject>mast cells</subject><subject>Medical sciences</subject><subject>Mesocricetus</subject><subject>Oligopeptides - pharmacology</subject><subject>Peritoneal Diseases - pathology</subject><subject>Peritoneal Diseases - prevention & control</subject><subject>Pharmacology. Drug treatments</subject><subject>Serine Endopeptidases - metabolism</subject><subject>Tissue Adhesions - pathology</subject><subject>Tissue Adhesions - prevention & control</subject><subject>Uterus - enzymology</subject><subject>Uterus - surgery</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0MtKxDAUgOEgio6XR1C6UXRRPUmbNF0NMngDwYW6Dkl6ykTapiadgXl7Oxd06SaB8J0k_IScU7ilQMXdOwDlKTDJroHdQAYyS9kemVDORcoFz_bJ5JcckeMYvwBA0IIdkiPKAMpM8AmZzuarVkdMXDd3xg0-xKTVq6QPuMRuSHofB99j0INbYqKrOUbnu6T2oR2PfHdKDmrdRDzb7Sfk8_HhY_acvr49vczuX1PLIR_SEoyVmmaVrFhpaJ4zNJICM9JWwgib1znaghteSdRg8gIpqxGoLPNixGV2Qq629_bBfy8wDqp10WLT6A79IqqCCinYBvIttMHHGLBWfXCtDitFQa3LqU05tc4yLmpTTrFx7mL3wMK0WP1N7VKN4HIHdLS6qYPurIt_LhNFASwf3XTrcMyxdBhUtA47i5ULaAdVeffPV34AQIGKaw</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Okamoto, Yukiko</creator><creator>Takai, Shinji</creator><creator>Yamada, Mayumi</creator><creator>Miyazaki, Mizuo</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Chymase inhibitors may prevent postoperative adhesion formation</title><author>Okamoto, Yukiko ; Takai, Shinji ; Yamada, Mayumi ; Miyazaki, Mizuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c504t-90bc8a13d8d29b1442eb8102b8cd6b6c4f4ec75b5d8ea0b47e12fe01894744293</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adhesion</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>chymase</topic><topic>chymase inhibitor</topic><topic>Chymases</topic><topic>Cricetinae</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Female</topic><topic>Genital system. Reproduction</topic><topic>Gynecologic Surgical Procedures - adverse effects</topic><topic>mast cells</topic><topic>Medical sciences</topic><topic>Mesocricetus</topic><topic>Oligopeptides - pharmacology</topic><topic>Peritoneal Diseases - pathology</topic><topic>Peritoneal Diseases - prevention & control</topic><topic>Pharmacology. Drug treatments</topic><topic>Serine Endopeptidases - metabolism</topic><topic>Tissue Adhesions - pathology</topic><topic>Tissue Adhesions - prevention & control</topic><topic>Uterus - enzymology</topic><topic>Uterus - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Okamoto, Yukiko</creatorcontrib><creatorcontrib>Takai, Shinji</creatorcontrib><creatorcontrib>Yamada, Mayumi</creatorcontrib><creatorcontrib>Miyazaki, Mizuo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okamoto, Yukiko</au><au>Takai, Shinji</au><au>Yamada, Mayumi</au><au>Miyazaki, Mizuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chymase inhibitors may prevent postoperative adhesion formation</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>77</volume><issue>5</issue><spage>1044</spage><epage>1048</epage><pages>1044-1048</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><coden>FESTAS</coden><abstract>Objective: To clarify the role of chymase produced from mast cells in adhesion formation, we measured chymase activity level and investigated the preventive effect of a chymase inhibitor, Suc-Val-Pro-Phe
p(OPh)
2, on the postoperative adhesion formation.
Design: Prospective randomized study using a surgical model for adhesion formation.
Setting: Clean hamsters in an academic research environment.
Animal(s): Sixty-seven female Syrian hamsters.
Intervention(s): Hamsters were given a lesion, produced by uterus scraping, and the chymase inhibitor (10 μM) or placebo was injected into the abdomen. Chymase activities in uteri were measured 3 days after the operation, and the scores of adhesion formations were assessed at 2 weeks.
Main Outcome Measure(s): Measurement of chymase activity and scoring of adhesion formation were performed.
Result(s): A significant increase of chymase activity in the injured uterus reduced by treatment with the chymase inhibitor. The scores of adhesion formations in the chymase inhibitor-treated group were significantly decreased in comparison with those in the placebo-treated group.
Conclusion(s): Chymase contained in mast cells plays an important role in adhesion formation, and a chymase inhibitor may be a useful drug for prevention of adhesion formation.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>12009365</pmid><doi>10.1016/S0015-0282(02)03083-2</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | Adhesion Animals Biological and medical sciences chymase chymase inhibitor Chymases Cricetinae Enzyme Inhibitors - pharmacology Female Genital system. Reproduction Gynecologic Surgical Procedures - adverse effects mast cells Medical sciences Mesocricetus Oligopeptides - pharmacology Peritoneal Diseases - pathology Peritoneal Diseases - prevention & control Pharmacology. Drug treatments Serine Endopeptidases - metabolism Tissue Adhesions - pathology Tissue Adhesions - prevention & control Uterus - enzymology Uterus - surgery |
| title | Chymase inhibitors may prevent postoperative adhesion formation |
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