The role of the transferrin–transferrin-receptor system in drug delivery and targeting
Exploration of the potential of site-specific and target-oriented drug delivery systems has gained interest recently. Indeed, the efficient cellular mechanism of transferrin uptake has been exploited for the delivery not only of anticancer drugs and proteins, but also of therapeutic genes into proli...
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| Veröffentlicht in: | Trends in pharmacological sciences (Regular ed.) 2002-05, Vol.23 (5), p.206-209 |
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| container_title | Trends in pharmacological sciences (Regular ed.) |
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| creator | Li, Hongyan Sun, Hongzhe Qian, Zhong Ming |
| description | Exploration of the potential of site-specific and target-oriented drug delivery systems has gained interest recently. Indeed, the efficient cellular mechanism of transferrin uptake has been exploited for the delivery not only of anticancer drugs and proteins, but also of therapeutic genes into proliferating malignant cells that overexpress transferrin receptors. In particular, the transferrin receptor offers great promise in the delivery of therapeutic agents across the blood–brain barrier to the brain.
Transferrin and the transferrin receptor system have shown great potential in the delivery of a wide variety of therapeutics (e.g. drugs and genes) across biological barriers. |
| doi_str_mv | 10.1016/S0165-6147(02)01989-2 |
| format | Article |
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Transferrin and the transferrin receptor system have shown great potential in the delivery of a wide variety of therapeutics (e.g. drugs and genes) across biological barriers.</description><subject>Animals</subject><subject>Blood-Brain Barrier</subject><subject>Brain - metabolism</subject><subject>drug</subject><subject>Drug Delivery Systems</subject><subject>gene delivery</subject><subject>Humans</subject><subject>monoclonal antibody</subject><subject>Receptors, Transferrin - metabolism</subject><subject>transferrin</subject><subject>Transferrin - metabolism</subject><subject>transferrin receptor</subject><issn>0165-6147</issn><issn>1873-3735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkM1qGzEQgEVpqZ00j5CgU2kOm46k3ZV0KsXkDwI51IXchCzNOirrXUeSDb7lHfKGfZKsf2hy62V-4JsZ5iPklMEFA1Z__zWEqqhZKb8BPwemlS74BzJmSopCSFF9JON_yIgcpfQHAITg7DMZMQ4gtRZj8jB9RBr7Fmnf0DzUOdouNRhj6P4-v7zriogOl7mPNG1SxgUNHfVxNace27DGuKG28zTbOMccuvkX8qmxbcKTQz4mv68up5Ob4u7--nby865wJZe5kN6jtzOnhSrBlrXiyK12SslaNcxyDZXCmcZKoK45OCgZ96IC4F5KZ704Jl_3e5exf1phymYRksO2tR32q2Qkq1XNuBjAag-62KcUsTHLGBY2bgwDs1VqdkrN1pcBbnZKDR_mzg4HVrMF-repg8MB-LEHcHhzHTCa5AJ2Dn0YlGXj-_CfE6-fcofV</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Li, Hongyan</creator><creator>Sun, Hongzhe</creator><creator>Qian, Zhong Ming</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>The role of the transferrin–transferrin-receptor system in drug delivery and targeting</title><author>Li, Hongyan ; Sun, Hongzhe ; Qian, Zhong Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-7ddedabc93840a4682e2a9c88768f1a29058eb9e53e9620c0412d35002d77cad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Blood-Brain Barrier</topic><topic>Brain - metabolism</topic><topic>drug</topic><topic>Drug Delivery Systems</topic><topic>gene delivery</topic><topic>Humans</topic><topic>monoclonal antibody</topic><topic>Receptors, Transferrin - metabolism</topic><topic>transferrin</topic><topic>Transferrin - metabolism</topic><topic>transferrin receptor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Hongyan</creatorcontrib><creatorcontrib>Sun, Hongzhe</creatorcontrib><creatorcontrib>Qian, Zhong Ming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Trends in pharmacological sciences (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Hongyan</au><au>Sun, Hongzhe</au><au>Qian, Zhong Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of the transferrin–transferrin-receptor system in drug delivery and targeting</atitle><jtitle>Trends in pharmacological sciences (Regular ed.)</jtitle><addtitle>Trends Pharmacol Sci</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>23</volume><issue>5</issue><spage>206</spage><epage>209</epage><pages>206-209</pages><issn>0165-6147</issn><eissn>1873-3735</eissn><abstract>Exploration of the potential of site-specific and target-oriented drug delivery systems has gained interest recently. Indeed, the efficient cellular mechanism of transferrin uptake has been exploited for the delivery not only of anticancer drugs and proteins, but also of therapeutic genes into proliferating malignant cells that overexpress transferrin receptors. In particular, the transferrin receptor offers great promise in the delivery of therapeutic agents across the blood–brain barrier to the brain.
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| identifier | ISSN: 0165-6147 |
| ispartof | Trends in pharmacological sciences (Regular ed.), 2002-05, Vol.23 (5), p.206-209 |
| issn | 0165-6147 1873-3735 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Blood-Brain Barrier Brain - metabolism drug Drug Delivery Systems gene delivery Humans monoclonal antibody Receptors, Transferrin - metabolism transferrin Transferrin - metabolism transferrin receptor |
| title | The role of the transferrin–transferrin-receptor system in drug delivery and targeting |
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