Slit Protein-mediated Inhibition of CXCR4-induced Chemotactic and Chemoinvasive Signaling Pathways in Breast Cancer Cells

Slit, which mediates its function by binding to the Roundabout (Robo) receptor, has been shown to regulate neuronal and CXCR4-mediated leukocyte migration. Slit-2 was shown to be frequently inactivated in lung and breast cancers because of hypermethylation of its promoter region. Furthermore, the CX...

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Veröffentlicht in:	The Journal of biological chemistry 2004-03, Vol.279 (10), p.9115-9124
Hauptverfasser:	Prasad, Anil, Fernandis, Aaron Z., Rao, Yi, Ganju, Ramesh K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Breast Neoplasms - metabolism Breast Neoplasms - pathology Cell Line, Tumor Chemotaxis - drug effects Female Humans Intercellular Signaling Peptides and Proteins MAP Kinase Signaling System - drug effects Nerve Tissue Proteins - metabolism Nerve Tissue Proteins - pharmacology Receptors, CCR4 Receptors, Chemokine - metabolism Receptors, Immunologic - metabolism Roundabout Proteins Signal Transduction - drug effects
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