Presence and induction of the enzyme NAD(P)H: Quinone oxidoreductase 1 in the central nervous system

NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyzes a reductive detoxification that is thought to protect cells against the adverse effects of quinones and related compounds. NQO1 activity is present in all tissues. Absence of the enzyme produces abnormalities in the redox state and seizures, suggesti...

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Veröffentlicht in:	Journal of comparative neurology (1911) 2004-04, Vol.471 (3), p.289-297
Hauptverfasser:	Stringer, Janet L., Gaikwad, Amos, Gonzales, Bianca N., Long Jr, Delwin J., Marks, Latoia M., Jaiswal, Anil K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antioxidant Bergmann glia Central Nervous System - chemistry Central Nervous System - enzymology Enzyme Induction - physiology Male Mice Mice, Inbred C57BL Mice, Knockout myelin NAD(P)H Dehydrogenase (Quinone) - analysis NAD(P)H Dehydrogenase (Quinone) - biosynthesis NAD(P)H Dehydrogenase (Quinone) - genetics NADPH Dehydrogenase Nerve Tissue Proteins - analysis Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics oligodendrocyte Rats Rats, Sprague-Dawley Rodentia
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