Structural refinement of inhibitors of urea-based soluble epoxide hydrolases

The soluble epoxide hydrolase (sEH) is involved in the metabolism of arachidonic, linoleic, and other fatty acid epoxides, endogenous chemical mediators that play an important role in blood pressure regulation and inflammation. 1,3-Disubstituted ureas, carbamates, and amides are new potent and stabl...

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Veröffentlicht in:	Biochemical pharmacology 2002-05, Vol.63 (9), p.1599-1608
Hauptverfasser:	Morisseau, Christophe, Goodrow, Marvin H., Newman, John W., Wheelock, Craig E., Dowdy, Deanna L., Hammock, Bruce D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Blood pressure Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Epoxide hydrolase Epoxide Hydrolases - antagonists & inhibitors Humans Immune response Mice Models, Chemical Protein Conformation Recombinant Proteins - chemistry Solubility Structure-Activity Relationship Structure–activity relationships Urea - chemistry Urea - pharmacology Urea inhibitors
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