CEACAM1 Expression in Cutaneous Malignant Melanoma Predicts the Development of Metastatic Disease
The cell adhesion molecule CEACAM1 is involved in intercellular adhesion and subsequent signal transduction events in a number of epithelia. CEACAM1 downregulation has been demonstrated in colorectal and prostate carcinomas. This study sought to analyze whether its expression in malignant melanoma i...
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| Veröffentlicht in: | Journal of clinical oncology 2002-05, Vol.20 (10), p.2530-2536 |
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| creator | THIES, Anka MOLL, Ingrid BERGER, Jürgen WAGENER, Christoph BRÜMMER, Jens SCHULZE, Hans-Joachim BRUNNER, Georg SCHUMACHER, Udo |
| description | The cell adhesion molecule CEACAM1 is involved in intercellular adhesion and subsequent signal transduction events in a number of epithelia. CEACAM1 downregulation has been demonstrated in colorectal and prostate carcinomas. This study sought to analyze whether its expression in malignant melanoma is associated with metastasis.
CEACAM1 expression was immunohistochemically evaluated in 100 primary cutaneous malignant melanomas and correlated with metastasis in a 10-year follow-up. Furthermore, CEACAM1 expression was analyzed in metastatic lesions (11 distant metastases and six sentinel lymph node metastases). Univariate Kaplan-Meier analysis and multivariate Cox proportional hazard regression analysis adjusted for standard prognostic indicators were performed to assess the prognostic relevance of CEACAM1 expression.
A total of 28 of 40 patients with CEACAM1-positive primary melanomas developed metastatic disease, compared with only six of 60 patients with CEACAM1-negative melanomas. Often, the strongest CEACAM1 expression was observed at the invading front. In addition, CEACAM1 expression was preserved in the metastatic lesions. Kaplan-Meier analysis revealed a highly significant association between CEACAM1 expression and metastasis (P |
| doi_str_mv | 10.1200/JCO.2002.05.033 |
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CEACAM1 expression was immunohistochemically evaluated in 100 primary cutaneous malignant melanomas and correlated with metastasis in a 10-year follow-up. Furthermore, CEACAM1 expression was analyzed in metastatic lesions (11 distant metastases and six sentinel lymph node metastases). Univariate Kaplan-Meier analysis and multivariate Cox proportional hazard regression analysis adjusted for standard prognostic indicators were performed to assess the prognostic relevance of CEACAM1 expression.
A total of 28 of 40 patients with CEACAM1-positive primary melanomas developed metastatic disease, compared with only six of 60 patients with CEACAM1-negative melanomas. Often, the strongest CEACAM1 expression was observed at the invading front. In addition, CEACAM1 expression was preserved in the metastatic lesions. Kaplan-Meier analysis revealed a highly significant association between CEACAM1 expression and metastasis (P <.0001); multivariate Cox regression analysis, including CEACAM1 expression status adjusted for tumor thickness, presence of ulceration, and mitotic rate, confirmed that CEACAM1 is an independent factor for the risk of metastasis and demonstrated that the predictive value of CEACAM1 expression is superior to that of tumor thickness.
Expression of the cell adhesion molecule CEACAM1 in the primary tumors in melanoma patients is associated with the subsequent development of metastatic disease. This raises the possibility of a functional role for this cell adhesion molecule in the metastatic spread it indicates.</description><identifier>ISSN: 0732-183X</identifier><identifier>EISSN: 1527-7755</identifier><identifier>DOI: 10.1200/JCO.2002.05.033</identifier><identifier>PMID: 12011132</identifier><language>eng</language><publisher>Baltimore, MD: American Society of Clinical Oncology</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antigens, CD - metabolism ; Antigens, Differentiation - metabolism ; Biological and medical sciences ; Biomarkers, Tumor - metabolism ; Cell Adhesion Molecules - metabolism ; Dermatology ; Disease Progression ; Disease-Free Survival ; Epitopes ; Female ; Humans ; Immunoenzyme Techniques ; Male ; Medical sciences ; Melanoma - metabolism ; Melanoma - pathology ; Middle Aged ; Mitotic Index ; Prognosis ; Receptors, Mitogen ; Skin Neoplasms - metabolism ; Skin Neoplasms - pathology ; Tumors of the skin and soft tissue. Premalignant lesions ; Ulcer - pathology</subject><ispartof>Journal of clinical oncology, 2002-05, Vol.20 (10), p.2530-2536</ispartof><rights>2002 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c467t-7e65e67bd9491b383326950cf816a9d37e62af7a2df29d848133d394c8cdd43d3</citedby><cites>FETCH-LOGICAL-c467t-7e65e67bd9491b383326950cf816a9d37e62af7a2df29d848133d394c8cdd43d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27929,27930</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13661796$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12011132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>THIES, Anka</creatorcontrib><creatorcontrib>MOLL, Ingrid</creatorcontrib><creatorcontrib>BERGER, Jürgen</creatorcontrib><creatorcontrib>WAGENER, Christoph</creatorcontrib><creatorcontrib>BRÜMMER, Jens</creatorcontrib><creatorcontrib>SCHULZE, Hans-Joachim</creatorcontrib><creatorcontrib>BRUNNER, Georg</creatorcontrib><creatorcontrib>SCHUMACHER, Udo</creatorcontrib><title>CEACAM1 Expression in Cutaneous Malignant Melanoma Predicts the Development of Metastatic Disease</title><title>Journal of clinical oncology</title><addtitle>J Clin Oncol</addtitle><description>The cell adhesion molecule CEACAM1 is involved in intercellular adhesion and subsequent signal transduction events in a number of epithelia. CEACAM1 downregulation has been demonstrated in colorectal and prostate carcinomas. This study sought to analyze whether its expression in malignant melanoma is associated with metastasis.
CEACAM1 expression was immunohistochemically evaluated in 100 primary cutaneous malignant melanomas and correlated with metastasis in a 10-year follow-up. Furthermore, CEACAM1 expression was analyzed in metastatic lesions (11 distant metastases and six sentinel lymph node metastases). Univariate Kaplan-Meier analysis and multivariate Cox proportional hazard regression analysis adjusted for standard prognostic indicators were performed to assess the prognostic relevance of CEACAM1 expression.
A total of 28 of 40 patients with CEACAM1-positive primary melanomas developed metastatic disease, compared with only six of 60 patients with CEACAM1-negative melanomas. Often, the strongest CEACAM1 expression was observed at the invading front. In addition, CEACAM1 expression was preserved in the metastatic lesions. Kaplan-Meier analysis revealed a highly significant association between CEACAM1 expression and metastasis (P <.0001); multivariate Cox regression analysis, including CEACAM1 expression status adjusted for tumor thickness, presence of ulceration, and mitotic rate, confirmed that CEACAM1 is an independent factor for the risk of metastasis and demonstrated that the predictive value of CEACAM1 expression is superior to that of tumor thickness.
Expression of the cell adhesion molecule CEACAM1 in the primary tumors in melanoma patients is associated with the subsequent development of metastatic disease. This raises the possibility of a functional role for this cell adhesion molecule in the metastatic spread it indicates.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antigens, CD - metabolism</subject><subject>Antigens, Differentiation - metabolism</subject><subject>Biological and medical sciences</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Cell Adhesion Molecules - metabolism</subject><subject>Dermatology</subject><subject>Disease Progression</subject><subject>Disease-Free Survival</subject><subject>Epitopes</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Melanoma - metabolism</subject><subject>Melanoma - pathology</subject><subject>Middle Aged</subject><subject>Mitotic Index</subject><subject>Prognosis</subject><subject>Receptors, Mitogen</subject><subject>Skin Neoplasms - metabolism</subject><subject>Skin Neoplasms - pathology</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><subject>Ulcer - pathology</subject><issn>0732-183X</issn><issn>1527-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0Dtv2zAUBWCiaNE4aeduBZcmkxw-RFIaDcV9IUY6tEA34pq8ihlQkivSffz70rCBTJcAv3tAHkLecbbkgrHbr93DskyxZGrJpHxBFlwJUxmj1EuyYEaKijfy5wW5TOmJMV43Ur0mF2WXcy7FgkC3XnWrDafrv_sZUwrTSMNIu0OGEadDohuI4XGEMdMNRhinAei3GX1wOdG8Q3qHvzFO-wGLmPqCMqQMOTh6FxJCwjfkVQ8x4dvzvCI_Pq6_d5-r-4dPX7rVfeVqbXJlUCvUZuvbuuVb2UgpdKuY6xuuofWy3AvoDQjfi9Y3dcOl9LKtXeO8r8vxilyfcvfz9OuAKdshJIcxnj5iDddNrWtW4O0JunlKacbe7ucwwPzPcmaPrdrSqj22apmypdWy8f4cfdgO6J_9ucYCPpwBJAexn2F0IT07qTU3rS7u5uR24XH3J8xo0wAxllhhn9wk2PEJQkkm_wMZCIvp</recordid><startdate>20020515</startdate><enddate>20020515</enddate><creator>THIES, Anka</creator><creator>MOLL, Ingrid</creator><creator>BERGER, Jürgen</creator><creator>WAGENER, Christoph</creator><creator>BRÜMMER, Jens</creator><creator>SCHULZE, Hans-Joachim</creator><creator>BRUNNER, Georg</creator><creator>SCHUMACHER, Udo</creator><general>American Society of Clinical Oncology</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020515</creationdate><title>CEACAM1 Expression in Cutaneous Malignant Melanoma Predicts the Development of Metastatic Disease</title><author>THIES, Anka ; MOLL, Ingrid ; BERGER, Jürgen ; WAGENER, Christoph ; BRÜMMER, Jens ; SCHULZE, Hans-Joachim ; BRUNNER, Georg ; SCHUMACHER, Udo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c467t-7e65e67bd9491b383326950cf816a9d37e62af7a2df29d848133d394c8cdd43d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antigens, CD - metabolism</topic><topic>Antigens, Differentiation - metabolism</topic><topic>Biological and medical sciences</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Cell Adhesion Molecules - metabolism</topic><topic>Dermatology</topic><topic>Disease Progression</topic><topic>Disease-Free Survival</topic><topic>Epitopes</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Melanoma - metabolism</topic><topic>Melanoma - pathology</topic><topic>Middle Aged</topic><topic>Mitotic Index</topic><topic>Prognosis</topic><topic>Receptors, Mitogen</topic><topic>Skin Neoplasms - metabolism</topic><topic>Skin Neoplasms - pathology</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><topic>Ulcer - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>THIES, Anka</creatorcontrib><creatorcontrib>MOLL, Ingrid</creatorcontrib><creatorcontrib>BERGER, Jürgen</creatorcontrib><creatorcontrib>WAGENER, Christoph</creatorcontrib><creatorcontrib>BRÜMMER, Jens</creatorcontrib><creatorcontrib>SCHULZE, Hans-Joachim</creatorcontrib><creatorcontrib>BRUNNER, Georg</creatorcontrib><creatorcontrib>SCHUMACHER, Udo</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>THIES, Anka</au><au>MOLL, Ingrid</au><au>BERGER, Jürgen</au><au>WAGENER, Christoph</au><au>BRÜMMER, Jens</au><au>SCHULZE, Hans-Joachim</au><au>BRUNNER, Georg</au><au>SCHUMACHER, Udo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CEACAM1 Expression in Cutaneous Malignant Melanoma Predicts the Development of Metastatic Disease</atitle><jtitle>Journal of clinical oncology</jtitle><addtitle>J Clin Oncol</addtitle><date>2002-05-15</date><risdate>2002</risdate><volume>20</volume><issue>10</issue><spage>2530</spage><epage>2536</epage><pages>2530-2536</pages><issn>0732-183X</issn><eissn>1527-7755</eissn><abstract>The cell adhesion molecule CEACAM1 is involved in intercellular adhesion and subsequent signal transduction events in a number of epithelia. CEACAM1 downregulation has been demonstrated in colorectal and prostate carcinomas. This study sought to analyze whether its expression in malignant melanoma is associated with metastasis.
CEACAM1 expression was immunohistochemically evaluated in 100 primary cutaneous malignant melanomas and correlated with metastasis in a 10-year follow-up. Furthermore, CEACAM1 expression was analyzed in metastatic lesions (11 distant metastases and six sentinel lymph node metastases). Univariate Kaplan-Meier analysis and multivariate Cox proportional hazard regression analysis adjusted for standard prognostic indicators were performed to assess the prognostic relevance of CEACAM1 expression.
A total of 28 of 40 patients with CEACAM1-positive primary melanomas developed metastatic disease, compared with only six of 60 patients with CEACAM1-negative melanomas. Often, the strongest CEACAM1 expression was observed at the invading front. In addition, CEACAM1 expression was preserved in the metastatic lesions. Kaplan-Meier analysis revealed a highly significant association between CEACAM1 expression and metastasis (P <.0001); multivariate Cox regression analysis, including CEACAM1 expression status adjusted for tumor thickness, presence of ulceration, and mitotic rate, confirmed that CEACAM1 is an independent factor for the risk of metastasis and demonstrated that the predictive value of CEACAM1 expression is superior to that of tumor thickness.
Expression of the cell adhesion molecule CEACAM1 in the primary tumors in melanoma patients is associated with the subsequent development of metastatic disease. This raises the possibility of a functional role for this cell adhesion molecule in the metastatic spread it indicates.</abstract><cop>Baltimore, MD</cop><pub>American Society of Clinical Oncology</pub><pmid>12011132</pmid><doi>10.1200/JCO.2002.05.033</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Antigens, CD - metabolism Antigens, Differentiation - metabolism Biological and medical sciences Biomarkers, Tumor - metabolism Cell Adhesion Molecules - metabolism Dermatology Disease Progression Disease-Free Survival Epitopes Female Humans Immunoenzyme Techniques Male Medical sciences Melanoma - metabolism Melanoma - pathology Middle Aged Mitotic Index Prognosis Receptors, Mitogen Skin Neoplasms - metabolism Skin Neoplasms - pathology Tumors of the skin and soft tissue. Premalignant lesions Ulcer - pathology |
| title | CEACAM1 Expression in Cutaneous Malignant Melanoma Predicts the Development of Metastatic Disease |
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