Maintenance Treatment with Fluoxetine is Necessary to Sustain Normal Levels of Synaptic Markers in an Experimental Model of Depression: Correlation with Behavioral Response

Dysfunction of hippocampal plasticity has been proposed to play a critical role in the pathophysiology of depression. However, antidepressant drug effects on synaptic plasticity and cytoskeletal remodeling remain controversial. The aim of the present study was to evaluate in animals exposed to the l...

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Veröffentlicht in:	Neuropsychopharmacology (New York, N.Y.) N.Y.), 2008-07, Vol.33 (8), p.1896-1908
Hauptverfasser:	Reinés, Analía, Cereseto, Marina, Ferrero, Alejandro, Sifonios, Laura, Podestá, Maria Fernanda, Wikinski, Silvia
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Animals Antidepressants Antidepressive Agents, Second-Generation - administration & dosage Antidepressive Agents, Second-Generation - therapeutic use Axons - physiology Behavior Behavior, Animal - drug effects Behavioral Sciences Biological and medical sciences Biological Psychology Biomarkers Cytoskeleton - drug effects Cytoskeleton - pathology Data Interpretation, Statistical Depression Depressive Disorder - drug therapy Depressive Disorder - metabolism Depressive Disorder - psychology Fluoxetine - administration & dosage Fluoxetine - therapeutic use Helplessness, Learned Hippocampus - drug effects Hippocampus - metabolism Hippocampus - physiopathology Image Processing, Computer-Assisted Immunohistochemistry Male Medical sciences Medicine Medicine & Public Health Mental depression Mood disorders Neurogenesis Neuronal Plasticity - drug effects Neuropharmacology Neurosciences original-article Pathophysiology Pharmacology. Drug treatments Pharmacotherapy Proteins Psychiatry Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Rats Rats, Wistar Recurrence Synapses - drug effects Synapses - metabolism Tissue Fixation
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