Synthesis and biological evaluation of neutrophilic inflammation inhibitors

In several non-infectious human diseases, such as ulcerous colitis, rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), the extravasal recruitment of neutrophils plays a crucial role in the development of tissue damage, which, when persistent, can lead to the irreversible organ dysfu...

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Veröffentlicht in:	Farmaco (Società chimica italiana : 1989) 2004-03, Vol.59 (3), p.223-235
Hauptverfasser:	Bruno, Olga, Brullo, Chiara, Arduino, Nicoletta, Schenone, Silvia, Ranise, Angelo, Bondavalli, Francesco, Ottonello, Luciano, Dapino, Patrizia, Dallegri, Franco
Format:	Artikel
Sprache:	eng
Schlagworte:	3',5'-Cyclic-AMP Phosphodiesterases - antagonists & inhibitors 3',5'-Cyclic-GMP Phosphodiesterases 3-Cyclopentyloxy-4-methoxybenzaldehyde derivatives 3-Cyclopentyloxy-4-methoxybenzoic acid derivatives Anti-Inflammatory Agents, Non-Steroidal - chemical synthesis Anti-Inflammatory Agents, Non-Steroidal - pharmacology Benzaldehydes Benzoates Binding, Competitive - drug effects Cell Separation Cyclic AMP - metabolism Cyclic Nucleotide Phosphodiesterases, Type 3 Cyclic Nucleotide Phosphodiesterases, Type 4 Cyclic Nucleotide Phosphodiesterases, Type 5 Cyclopentanes Dose-Response Relationship, Drug Humans Hydroxybenzoate Ethers In Vitro Techniques Indicators and Reagents Neutrophil inhibitors Neutrophilic inflammation Neutrophils - drug effects Neutrophils - metabolism PDE4 inhibitors Phosphodiesterase Inhibitors - metabolism Phosphodiesterase Inhibitors - pharmacology Phosphoric Diester Hydrolases - metabolism Rolipram - metabolism Rolipram - pharmacology Superoxides - metabolism Tumor Necrosis Factor-alpha - antagonists & inhibitors
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