Dual HIV-1 infection associated with rapid disease progression
Infection with two strains of HIV-1 has implications for understanding HIV transmission and vaccine development; however, frequency and pathogenic consequences of dual infection are unknown. We assessed 64 patients for dual infection with heteroduplex mobility assay, viral sequencing, and phylogenet...
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| Veröffentlicht in: | The Lancet (British edition) 2004-02, Vol.363 (9409), p.619-622 |
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| creator | Gottlieb, Geoffrey S Nickle, David C Jensen, Mark A Wong, Kim G Grobler, Jandre Li, Fusheng Liu, Shan-Lu Rademeyer, Cecilia Learn, Gerald H Abdool Karim, Salim S Williamson, Carolyn Corey, Lawrence Margolick, Joseph B Mullins, James I |
| description | Infection with two strains of HIV-1 has implications for understanding HIV transmission and vaccine development; however, frequency and pathogenic consequences of dual infection are unknown. We assessed 64 patients for dual infection with heteroduplex mobility assay, viral sequencing, and phylogenetic methods. HIV disease outcomes were available in 34 patients. Five of these with AIDS endpoints had dual infection with HIV-1: four were cases of coinfection and one was superinfection. In all five, time from seroconversion to clinical AIDS or to CD4+ T-cell count less than 200 cells per μL was very rapid ( |
| doi_str_mv | 10.1016/S0140-6736(04)15596-7 |
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We assessed 64 patients for dual infection with heteroduplex mobility assay, viral sequencing, and phylogenetic methods. HIV disease outcomes were available in 34 patients. Five of these with AIDS endpoints had dual infection with HIV-1: four were cases of coinfection and one was superinfection. In all five, time from seroconversion to clinical AIDS or to CD4+ T-cell count less than 200 cells per μL was very rapid (<3·4 and <3·1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level.</description><identifier>ISSN: 0140-6736</identifier><identifier>EISSN: 1474-547X</identifier><identifier>DOI: 10.1016/S0140-6736(04)15596-7</identifier><identifier>PMID: 14987889</identifier><identifier>CODEN: LANCAO</identifier><language>eng</language><publisher>London: Elsevier Ltd</publisher><subject>Acquired immune deficiency syndrome ; Acquired Immunodeficiency Syndrome - blood ; Acquired Immunodeficiency Syndrome - diagnosis ; Acquired Immunodeficiency Syndrome - virology ; Adult ; AIDS ; Antiretroviral agents ; Biological and medical sciences ; Branched DNA Signal Amplification Assay ; CD4 antigen ; CD4-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - immunology ; Disease Progression ; Disease transmission ; Female ; HIV ; HIV Infections - blood ; HIV Infections - diagnosis ; HIV Infections - virology ; HIV-1 - classification ; HIV-1 - immunology ; HIV-1 - isolation & purification ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Infections ; Infectious diseases ; Laboratories ; Lymphocytes ; Lymphocytes T ; Male ; Medical research ; Medical sciences ; Pathology ; Patients ; Phylogenetics ; Phylogeny ; Plasma ; Retrospective Studies ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Viral - blood ; RNA, Viral - immunology ; Seroconversion ; Statistical analysis ; Superinfection ; Superinfection - diagnosis ; Superinfection - immunology ; Superinfection - virology ; Survival analysis ; Vaccine development ; Vaccines ; Viral diseases ; Viral diseases of the lymphoid tissue and the blood. 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Feb 21, 2004</rights><rights>Copyright Elsevier Limited Feb 21, 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c500t-ca850a059e6d5d9d65327c1dd31af5d47c679ed5945a63ab1548c55b6510139f3</citedby><cites>FETCH-LOGICAL-c500t-ca850a059e6d5d9d65327c1dd31af5d47c679ed5945a63ab1548c55b6510139f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/199050216?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994,64384,64386,64388,72340</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15505048$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14987889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gottlieb, Geoffrey S</creatorcontrib><creatorcontrib>Nickle, David C</creatorcontrib><creatorcontrib>Jensen, Mark A</creatorcontrib><creatorcontrib>Wong, Kim G</creatorcontrib><creatorcontrib>Grobler, Jandre</creatorcontrib><creatorcontrib>Li, Fusheng</creatorcontrib><creatorcontrib>Liu, Shan-Lu</creatorcontrib><creatorcontrib>Rademeyer, Cecilia</creatorcontrib><creatorcontrib>Learn, Gerald H</creatorcontrib><creatorcontrib>Abdool Karim, Salim S</creatorcontrib><creatorcontrib>Williamson, Carolyn</creatorcontrib><creatorcontrib>Corey, Lawrence</creatorcontrib><creatorcontrib>Margolick, Joseph B</creatorcontrib><creatorcontrib>Mullins, James I</creatorcontrib><title>Dual HIV-1 infection associated with rapid disease progression</title><title>The Lancet (British edition)</title><addtitle>Lancet</addtitle><description>Infection with two strains of HIV-1 has implications for understanding HIV transmission and vaccine development; however, frequency and pathogenic consequences of dual infection are unknown. We assessed 64 patients for dual infection with heteroduplex mobility assay, viral sequencing, and phylogenetic methods. HIV disease outcomes were available in 34 patients. Five of these with AIDS endpoints had dual infection with HIV-1: four were cases of coinfection and one was superinfection. In all five, time from seroconversion to clinical AIDS or to CD4+ T-cell count less than 200 cells per μL was very rapid (<3·4 and <3·1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level.</description><subject>Acquired immune deficiency syndrome</subject><subject>Acquired Immunodeficiency Syndrome - blood</subject><subject>Acquired Immunodeficiency Syndrome - diagnosis</subject><subject>Acquired Immunodeficiency Syndrome - virology</subject><subject>Adult</subject><subject>AIDS</subject><subject>Antiretroviral agents</subject><subject>Biological and medical sciences</subject><subject>Branched DNA Signal Amplification Assay</subject><subject>CD4 antigen</subject><subject>CD4-Positive T-Lymphocytes - immunology</subject><subject>CD8-Positive T-Lymphocytes - immunology</subject><subject>Disease Progression</subject><subject>Disease transmission</subject><subject>Female</subject><subject>HIV</subject><subject>HIV Infections - blood</subject><subject>HIV Infections - diagnosis</subject><subject>HIV Infections - virology</subject><subject>HIV-1 - classification</subject><subject>HIV-1 - immunology</subject><subject>HIV-1 - isolation & purification</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Laboratories</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Male</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Pathology</subject><subject>Patients</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>Plasma</subject><subject>Retrospective Studies</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Viral - blood</subject><subject>RNA, Viral - immunology</subject><subject>Seroconversion</subject><subject>Statistical analysis</subject><subject>Superinfection</subject><subject>Superinfection - diagnosis</subject><subject>Superinfection - immunology</subject><subject>Superinfection - virology</subject><subject>Survival analysis</subject><subject>Vaccine development</subject><subject>Vaccines</subject><subject>Viral diseases</subject><subject>Viral diseases of the lymphoid tissue and the blood. 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Nickle, David C ; Jensen, Mark A ; Wong, Kim G ; Grobler, Jandre ; Li, Fusheng ; Liu, Shan-Lu ; Rademeyer, Cecilia ; Learn, Gerald H ; Abdool Karim, Salim S ; Williamson, Carolyn ; Corey, Lawrence ; Margolick, Joseph B ; Mullins, James I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c500t-ca850a059e6d5d9d65327c1dd31af5d47c679ed5945a63ab1548c55b6510139f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Acquired Immunodeficiency Syndrome - blood</topic><topic>Acquired Immunodeficiency Syndrome - diagnosis</topic><topic>Acquired Immunodeficiency Syndrome - virology</topic><topic>Adult</topic><topic>AIDS</topic><topic>Antiretroviral agents</topic><topic>Biological and medical sciences</topic><topic>Branched DNA Signal Amplification Assay</topic><topic>CD4 antigen</topic><topic>CD4-Positive T-Lymphocytes - immunology</topic><topic>CD8-Positive T-Lymphocytes - immunology</topic><topic>Disease Progression</topic><topic>Disease transmission</topic><topic>Female</topic><topic>HIV</topic><topic>HIV Infections - blood</topic><topic>HIV Infections - diagnosis</topic><topic>HIV Infections - virology</topic><topic>HIV-1 - classification</topic><topic>HIV-1 - immunology</topic><topic>HIV-1 - isolation & purification</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Laboratories</topic><topic>Lymphocytes</topic><topic>Lymphocytes T</topic><topic>Male</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Pathology</topic><topic>Patients</topic><topic>Phylogenetics</topic><topic>Phylogeny</topic><topic>Plasma</topic><topic>Retrospective Studies</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Viral - blood</topic><topic>RNA, Viral - immunology</topic><topic>Seroconversion</topic><topic>Statistical analysis</topic><topic>Superinfection</topic><topic>Superinfection - diagnosis</topic><topic>Superinfection - immunology</topic><topic>Superinfection - virology</topic><topic>Survival analysis</topic><topic>Vaccine development</topic><topic>Vaccines</topic><topic>Viral diseases</topic><topic>Viral diseases of the lymphoid tissue and the blood. 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We assessed 64 patients for dual infection with heteroduplex mobility assay, viral sequencing, and phylogenetic methods. HIV disease outcomes were available in 34 patients. Five of these with AIDS endpoints had dual infection with HIV-1: four were cases of coinfection and one was superinfection. In all five, time from seroconversion to clinical AIDS or to CD4+ T-cell count less than 200 cells per μL was very rapid (<3·4 and <3·1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level.</abstract><cop>London</cop><pub>Elsevier Ltd</pub><pmid>14987889</pmid><doi>10.1016/S0140-6736(04)15596-7</doi><tpages>4</tpages></addata></record> |
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| ispartof | The Lancet (British edition), 2004-02, Vol.363 (9409), p.619-622 |
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| subjects | Acquired immune deficiency syndrome Acquired Immunodeficiency Syndrome - blood Acquired Immunodeficiency Syndrome - diagnosis Acquired Immunodeficiency Syndrome - virology Adult AIDS Antiretroviral agents Biological and medical sciences Branched DNA Signal Amplification Assay CD4 antigen CD4-Positive T-Lymphocytes - immunology CD8-Positive T-Lymphocytes - immunology Disease Progression Disease transmission Female HIV HIV Infections - blood HIV Infections - diagnosis HIV Infections - virology HIV-1 - classification HIV-1 - immunology HIV-1 - isolation & purification Human immunodeficiency virus Human viral diseases Humans Infections Infectious diseases Laboratories Lymphocytes Lymphocytes T Male Medical research Medical sciences Pathology Patients Phylogenetics Phylogeny Plasma Retrospective Studies Reverse Transcriptase Polymerase Chain Reaction RNA, Viral - blood RNA, Viral - immunology Seroconversion Statistical analysis Superinfection Superinfection - diagnosis Superinfection - immunology Superinfection - virology Survival analysis Vaccine development Vaccines Viral diseases Viral diseases of the lymphoid tissue and the blood. Aids Viral Load Viruses |
| title | Dual HIV-1 infection associated with rapid disease progression |
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