LC and TLC determination of cinnarizine in pharmaceutical preparations and serum

New high performance liquid chromatography (HPLC) and thin layer densitometry (TLC) methods are developed for quantification of cinnarizine in dosage forms in the presence of its photo-degradation products and related substances and in the presence of its metabolites in serum. Mobile phases consisti...

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Veröffentlicht in:	Journal of pharmaceutical and biomedical analysis 2002-05, Vol.28 (3), p.711-719
Hauptverfasser:	Hassan, Saad S.M, Elmosallamy, Mohamed A.F, Abbas, Alaa B
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Animals Bioavailability Bioequivalency Biological and medical sciences Calibration Chromatography, High Pressure Liquid Chromatography, Thin Layer Cinnarizine - analysis Cinnarizine - blood Cinnarizine - pharmacokinetics Cinnarizine assay Cinnarizine photo- and acid-degradation products Densitometry Female General pharmacology High performance liquid chromatography Histamine H1 Antagonists - analysis Histamine H1 Antagonists - blood Histamine H1 Antagonists - pharmacokinetics Indicators and Reagents Kinetics Male Medical sciences Pharmacology. Drug treatments Rats Rats, Sprague-Dawley Solubility Spectrophotometry, Infrared Spectrophotometry, Ultraviolet Tablet dissolution rate Tablets Therapeutic Equivalency Thin layer densitometry
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