Clinical, Microscopic, and Molecular Aspects of Canine Leproid Granuloma in the United States
Leproid granulomas from seven dogs in the United States were evaluated. Gross characteristics included nodular and ulcerated dermal and subcutaneous lesions primarily on the caudal aspects of the pinnae and to a lesser extent on the muzzle, face, and forelimbs. In all except one dog, there was compl...
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| Veröffentlicht in: | Veterinary pathology 2002-03, Vol.39 (2), p.234-239 |
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| creator | Foley, J. E. Borjesson, D. L Gross, T. Rand, C. Needham, M. Poland, A. |
| description | Leproid granulomas from seven dogs in the United States were evaluated. Gross characteristics included nodular and ulcerated dermal and subcutaneous lesions primarily on the caudal aspects of the pinnae and to a lesser extent on the muzzle, face, and forelimbs. In all except one dog, there was complete regression of the lesions within 6 months, either with no therapy or after surgical resection. Cytology or histopathology revealed pyogranulomatous inflammation with few to many acid-fast mycobacterial bacilli within macrophages. The organisms could not be cultivated in vitro. DNA sequencing of part of the 16S ribosomal RNA gene region revealed 99–100% homology among fragments from five of these dogs and fragments from dogs in the South Pacific. This syndrome occurs in dogs in North America and the prognosis is excellent, in contrast to the prognosis for rapid-growing or tuberculous mycobacteriosis. |
| doi_str_mv | 10.1354/vp.39-2-234 |
| format | Article |
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E.</creatorcontrib><creatorcontrib>Borjesson, D.</creatorcontrib><creatorcontrib>L Gross, T.</creatorcontrib><creatorcontrib>Rand, C.</creatorcontrib><creatorcontrib>Needham, M.</creatorcontrib><creatorcontrib>Poland, A.</creatorcontrib><title>Clinical, Microscopic, and Molecular Aspects of Canine Leproid Granuloma in the United States</title><title>Veterinary pathology</title><addtitle>Vet Pathol</addtitle><description>Leproid granulomas from seven dogs in the United States were evaluated. Gross characteristics included nodular and ulcerated dermal and subcutaneous lesions primarily on the caudal aspects of the pinnae and to a lesser extent on the muzzle, face, and forelimbs. In all except one dog, there was complete regression of the lesions within 6 months, either with no therapy or after surgical resection. Cytology or histopathology revealed pyogranulomatous inflammation with few to many acid-fast mycobacterial bacilli within macrophages. The organisms could not be cultivated in vitro. DNA sequencing of part of the 16S ribosomal RNA gene region revealed 99–100% homology among fragments from five of these dogs and fragments from dogs in the South Pacific. This syndrome occurs in dogs in North America and the prognosis is excellent, in contrast to the prognosis for rapid-growing or tuberculous mycobacteriosis.</description><subject>Animals</subject><subject>Dog Diseases - microbiology</subject><subject>Dog Diseases - pathology</subject><subject>Dogs</subject><subject>Female</subject><subject>Granuloma - microbiology</subject><subject>Granuloma - pathology</subject><subject>Granuloma - veterinary</subject><subject>Male</subject><subject>Mycobacterium - genetics</subject><subject>Mycobacterium - isolation & purification</subject><subject>Mycobacterium Infections - microbiology</subject><subject>Mycobacterium Infections - pathology</subject><subject>Mycobacterium Infections - veterinary</subject><subject>Polymerase Chain Reaction - veterinary</subject><subject>Prognosis</subject><subject>RNA, Ribosomal, 16S - analysis</subject><subject>Skin Diseases, Bacterial - microbiology</subject><subject>Skin Diseases, Bacterial - pathology</subject><subject>Skin Diseases, Bacterial - veterinary</subject><issn>0300-9858</issn><issn>1544-2217</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkM9LwzAUx4Mobk5P3iUnEVxnfjRdcxxDp7DhQXeUkCavmtGltWkH_vdmbODFd3k8-PDhfb8IXVMyoVykD7tmwmXCEsbTEzSkIk0Txuj0FA0JJySRucgH6CKEDSGMyXx6jgaUESJJRofoY14574yuxnjlTFsHUzfOjLH2Fq_qCkxf6RbPQgOmC7gu8Vx75wEvoWlrZ_Gi1b6v6q3GzuPuC_Dauw4sfut0B-ESnZW6CnB13CO0fnp8nz8ny9fFy3y2TAyneZcUJrOCpYU0IpOWxYvxssjjEAkilTwV1kIJhRQij5lJahnLaFlG3Bib8RG6PXjjU989hE5tXTBQVdpD3Qc1pVlUMR7B-wO4jxpaKFXTuq1ufxQlat-m2jWKS8VUbDPSN0dtX2zB_rHH-iJwdwCC_gS1qfvWx5j_un4BrF18aw</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Foley, J. 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E.</creatorcontrib><creatorcontrib>Borjesson, D.</creatorcontrib><creatorcontrib>L Gross, T.</creatorcontrib><creatorcontrib>Rand, C.</creatorcontrib><creatorcontrib>Needham, M.</creatorcontrib><creatorcontrib>Poland, A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Veterinary pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Foley, J. 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Cytology or histopathology revealed pyogranulomatous inflammation with few to many acid-fast mycobacterial bacilli within macrophages. The organisms could not be cultivated in vitro. DNA sequencing of part of the 16S ribosomal RNA gene region revealed 99–100% homology among fragments from five of these dogs and fragments from dogs in the South Pacific. This syndrome occurs in dogs in North America and the prognosis is excellent, in contrast to the prognosis for rapid-growing or tuberculous mycobacteriosis.</abstract><cop>Los Angeles, CA</cop><pub>SAGE Publications</pub><pmid>12009061</pmid><doi>10.1354/vp.39-2-234</doi><tpages>6</tpages></addata></record> |
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| subjects | Animals Dog Diseases - microbiology Dog Diseases - pathology Dogs Female Granuloma - microbiology Granuloma - pathology Granuloma - veterinary Male Mycobacterium - genetics Mycobacterium - isolation & purification Mycobacterium Infections - microbiology Mycobacterium Infections - pathology Mycobacterium Infections - veterinary Polymerase Chain Reaction - veterinary Prognosis RNA, Ribosomal, 16S - analysis Skin Diseases, Bacterial - microbiology Skin Diseases, Bacterial - pathology Skin Diseases, Bacterial - veterinary |
| title | Clinical, Microscopic, and Molecular Aspects of Canine Leproid Granuloma in the United States |
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