Effects of tributyltin on barrier functions in human intestinal Caco-2 cells

The effect of tributyltin (TBT) on human intestinal epithelial cell functions was investigated by using human intestinal Caco-2 cell monolayers. We paid particular attention to the effect of TBT on two barrier functions: the tight junction as a physical barrier and MDR1/P-glycoprotein as a biologica...

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Veröffentlicht in:	Biochemical and biophysical research communications 2004-03, Vol.315 (4), p.991-997
Hauptverfasser:	Tsukazaki, Masashi, Satsu, Hideo, Mori, Akira, Sugita-Konishi, Yoshiko, Shimizu, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Cytoskeleton - drug effects Actin Cytoskeleton - ultrastructure Alkaline Phosphatase - metabolism ATP-Binding Cassette, Sub-Family B, Member 1 - biosynthesis ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Barrier function Caco-2 Caco-2 Cells CD13 Antigens - metabolism Cell Membrane Permeability - drug effects Cell Membrane Permeability - physiology Daunorubicin - analogs & derivatives Daunorubicin - pharmacokinetics Electric Impedance Epithelium - drug effects Epithelium - metabolism Humans Intestinal Absorption - drug effects Intestinal Absorption - physiology Intestinal Mucosa - cytology Intestinal Mucosa - drug effects Intestinal Mucosa - metabolism Intestinal Mucosa - physiology Intestine Isoquinolines - pharmacokinetics MDR1 Multidrug resistance P-glycoprotein Rhodamine 123 - pharmacokinetics RNA, Messenger - biosynthesis Tight junction Tight Junctions - drug effects Tight Junctions - physiology Time Factors Trialkyltin Compounds - pharmacology Tributyltin Xenobiotic
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