Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors
Regulation of AMPA receptor (AMPAR) trafficking is important for neural plasticity. Here we examined the trafficking and synthesis of the GluR1 and GluR2 subunits using ReAsH-EDT 2 and FlAsH-EDT 2 staining. Activity blockade of rat cultured neurons increased dendritic GluR1, but not GluR2, levels. E...
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| Veröffentlicht in: | Nature neuroscience 2004-03, Vol.7 (3), p.244-253 |
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| creator | Malenka, Robert C Ju, William Morishita, Wade Tsui, Jennifer Gaietta, Guido Deerinck, Thomas J Adams, Stephen R Garner, Craig C Tsien, Roger Y Ellisman, Mark H |
| description | Regulation of AMPA receptor (AMPAR) trafficking is important for neural plasticity. Here we examined the trafficking and synthesis of the GluR1 and GluR2 subunits using ReAsH-EDT
2
and FlAsH-EDT
2
staining. Activity blockade of rat cultured neurons increased dendritic GluR1, but not GluR2, levels. Examination of transected dendrites revealed that both AMPAR subunits were synthesized in dendrites and that activity blockade enhanced dendritic synthesis of GluR1 but not GluR2. In contrast, acute pharmacological manipulations increased dendritic synthesis of both subunits. AMPARs synthesized in dendrites were inserted into synaptic plasma membranes and, after activity blockade, the electrophysiological properties of native synaptic AMPARs changed in the manner predicted by the imaging experiments. In addition to providing a novel mechanism for synaptic modifications, these results point out the advantages of using FlAsH-EDT
2
and ReAsH-EDT
2
for studying the trafficking of newly synthesized proteins in local cellular compartments such as dendrites. |
| doi_str_mv | 10.1038/nn1189 |
| format | Article |
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2
and FlAsH-EDT
2
staining. Activity blockade of rat cultured neurons increased dendritic GluR1, but not GluR2, levels. Examination of transected dendrites revealed that both AMPAR subunits were synthesized in dendrites and that activity blockade enhanced dendritic synthesis of GluR1 but not GluR2. In contrast, acute pharmacological manipulations increased dendritic synthesis of both subunits. AMPARs synthesized in dendrites were inserted into synaptic plasma membranes and, after activity blockade, the electrophysiological properties of native synaptic AMPARs changed in the manner predicted by the imaging experiments. In addition to providing a novel mechanism for synaptic modifications, these results point out the advantages of using FlAsH-EDT
2
and ReAsH-EDT
2
for studying the trafficking of newly synthesized proteins in local cellular compartments such as dendrites.</description><identifier>ISSN: 1097-6256</identifier><identifier>EISSN: 1546-1726</identifier><identifier>DOI: 10.1038/nn1189</identifier><identifier>PMID: 14770185</identifier><identifier>CODEN: NANEFN</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>Action Potentials - drug effects ; Action Potentials - genetics ; Amino Acid Motifs - drug effects ; Amino Acid Motifs - physiology ; Animal Genetics and Genomics ; Animals ; Arsenicals ; Behavioral Sciences ; Biological Techniques ; Biomedical and Life Sciences ; Biomedicine ; Cell receptors ; Cells, Cultured ; Cysteine ; Dendrites ; Dendrites - drug effects ; Dendrites - metabolism ; Dendrites - ultrastructure ; Excitatory Amino Acid Antagonists - pharmacology ; Fetus ; Glutamic Acid - pharmacology ; Hippocampus - cytology ; Hippocampus - drug effects ; Hippocampus - metabolism ; Neurobiology ; Neuronal Plasticity - drug effects ; Neuronal Plasticity - genetics ; Neurosciences ; Oxazines ; Peptide Fragments ; Physiological aspects ; Protein Transport - physiology ; Rats ; Rats, Sprague-Dawley ; Receptors, AMPA - antagonists & inhibitors ; Receptors, AMPA - biosynthesis ; Receptors, AMPA - genetics ; RNA, Messenger - drug effects ; RNA, Messenger - metabolism ; Synapses ; Synaptic Membranes - drug effects ; Synaptic Membranes - metabolism ; Synaptic Membranes - ultrastructure ; Synaptic Transmission - drug effects ; Synaptic Transmission - genetics ; Up-Regulation - physiology</subject><ispartof>Nature neuroscience, 2004-03, Vol.7 (3), p.244-253</ispartof><rights>Springer Nature America, Inc. 2004</rights><rights>COPYRIGHT 2004 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2004</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-b11c88adc93f2fbd3cc014d7f71e2aeca96ead69c6f673751994059ad7625b613</citedby><cites>FETCH-LOGICAL-c461t-b11c88adc93f2fbd3cc014d7f71e2aeca96ead69c6f673751994059ad7625b613</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2727,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14770185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Malenka, Robert C</creatorcontrib><creatorcontrib>Ju, William</creatorcontrib><creatorcontrib>Morishita, Wade</creatorcontrib><creatorcontrib>Tsui, Jennifer</creatorcontrib><creatorcontrib>Gaietta, Guido</creatorcontrib><creatorcontrib>Deerinck, Thomas J</creatorcontrib><creatorcontrib>Adams, Stephen R</creatorcontrib><creatorcontrib>Garner, Craig C</creatorcontrib><creatorcontrib>Tsien, Roger Y</creatorcontrib><creatorcontrib>Ellisman, Mark H</creatorcontrib><title>Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors</title><title>Nature neuroscience</title><addtitle>Nat Neurosci</addtitle><addtitle>Nat Neurosci</addtitle><description>Regulation of AMPA receptor (AMPAR) trafficking is important for neural plasticity. Here we examined the trafficking and synthesis of the GluR1 and GluR2 subunits using ReAsH-EDT
2
and FlAsH-EDT
2
staining. Activity blockade of rat cultured neurons increased dendritic GluR1, but not GluR2, levels. Examination of transected dendrites revealed that both AMPAR subunits were synthesized in dendrites and that activity blockade enhanced dendritic synthesis of GluR1 but not GluR2. In contrast, acute pharmacological manipulations increased dendritic synthesis of both subunits. AMPARs synthesized in dendrites were inserted into synaptic plasma membranes and, after activity blockade, the electrophysiological properties of native synaptic AMPARs changed in the manner predicted by the imaging experiments. In addition to providing a novel mechanism for synaptic modifications, these results point out the advantages of using FlAsH-EDT
2
and ReAsH-EDT
2
for studying the trafficking of newly synthesized proteins in local cellular compartments such as dendrites.</description><subject>Action Potentials - drug effects</subject><subject>Action Potentials - genetics</subject><subject>Amino Acid Motifs - drug effects</subject><subject>Amino Acid Motifs - physiology</subject><subject>Animal Genetics and Genomics</subject><subject>Animals</subject><subject>Arsenicals</subject><subject>Behavioral Sciences</subject><subject>Biological Techniques</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Cell receptors</subject><subject>Cells, Cultured</subject><subject>Cysteine</subject><subject>Dendrites</subject><subject>Dendrites - drug effects</subject><subject>Dendrites - metabolism</subject><subject>Dendrites - ultrastructure</subject><subject>Excitatory Amino Acid Antagonists - pharmacology</subject><subject>Fetus</subject><subject>Glutamic Acid - pharmacology</subject><subject>Hippocampus - cytology</subject><subject>Hippocampus - drug effects</subject><subject>Hippocampus - metabolism</subject><subject>Neurobiology</subject><subject>Neuronal Plasticity - drug effects</subject><subject>Neuronal Plasticity - genetics</subject><subject>Neurosciences</subject><subject>Oxazines</subject><subject>Peptide Fragments</subject><subject>Physiological aspects</subject><subject>Protein Transport - physiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Receptors, AMPA - antagonists & inhibitors</subject><subject>Receptors, AMPA - biosynthesis</subject><subject>Receptors, AMPA - genetics</subject><subject>RNA, Messenger - drug effects</subject><subject>RNA, Messenger - metabolism</subject><subject>Synapses</subject><subject>Synaptic Membranes - drug effects</subject><subject>Synaptic Membranes - metabolism</subject><subject>Synaptic Membranes - ultrastructure</subject><subject>Synaptic Transmission - drug effects</subject><subject>Synaptic Transmission - genetics</subject><subject>Up-Regulation - 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Academic</collection><jtitle>Nature neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malenka, Robert C</au><au>Ju, William</au><au>Morishita, Wade</au><au>Tsui, Jennifer</au><au>Gaietta, Guido</au><au>Deerinck, Thomas J</au><au>Adams, Stephen R</au><au>Garner, Craig C</au><au>Tsien, Roger Y</au><au>Ellisman, Mark H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors</atitle><jtitle>Nature neuroscience</jtitle><stitle>Nat Neurosci</stitle><addtitle>Nat Neurosci</addtitle><date>2004-03-01</date><risdate>2004</risdate><volume>7</volume><issue>3</issue><spage>244</spage><epage>253</epage><pages>244-253</pages><issn>1097-6256</issn><eissn>1546-1726</eissn><coden>NANEFN</coden><abstract>Regulation of AMPA receptor (AMPAR) trafficking is important for neural plasticity. Here we examined the trafficking and synthesis of the GluR1 and GluR2 subunits using ReAsH-EDT
2
and FlAsH-EDT
2
staining. Activity blockade of rat cultured neurons increased dendritic GluR1, but not GluR2, levels. Examination of transected dendrites revealed that both AMPAR subunits were synthesized in dendrites and that activity blockade enhanced dendritic synthesis of GluR1 but not GluR2. In contrast, acute pharmacological manipulations increased dendritic synthesis of both subunits. AMPARs synthesized in dendrites were inserted into synaptic plasma membranes and, after activity blockade, the electrophysiological properties of native synaptic AMPARs changed in the manner predicted by the imaging experiments. In addition to providing a novel mechanism for synaptic modifications, these results point out the advantages of using FlAsH-EDT
2
and ReAsH-EDT
2
for studying the trafficking of newly synthesized proteins in local cellular compartments such as dendrites.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>14770185</pmid><doi>10.1038/nn1189</doi><tpages>10</tpages></addata></record> |
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| ispartof | Nature neuroscience, 2004-03, Vol.7 (3), p.244-253 |
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| language | eng |
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| subjects | Action Potentials - drug effects Action Potentials - genetics Amino Acid Motifs - drug effects Amino Acid Motifs - physiology Animal Genetics and Genomics Animals Arsenicals Behavioral Sciences Biological Techniques Biomedical and Life Sciences Biomedicine Cell receptors Cells, Cultured Cysteine Dendrites Dendrites - drug effects Dendrites - metabolism Dendrites - ultrastructure Excitatory Amino Acid Antagonists - pharmacology Fetus Glutamic Acid - pharmacology Hippocampus - cytology Hippocampus - drug effects Hippocampus - metabolism Neurobiology Neuronal Plasticity - drug effects Neuronal Plasticity - genetics Neurosciences Oxazines Peptide Fragments Physiological aspects Protein Transport - physiology Rats Rats, Sprague-Dawley Receptors, AMPA - antagonists & inhibitors Receptors, AMPA - biosynthesis Receptors, AMPA - genetics RNA, Messenger - drug effects RNA, Messenger - metabolism Synapses Synaptic Membranes - drug effects Synaptic Membranes - metabolism Synaptic Membranes - ultrastructure Synaptic Transmission - drug effects Synaptic Transmission - genetics Up-Regulation - physiology |
| title | Activity-dependent regulation of dendritic synthesis and trafficking of AMPA receptors |
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