Mice Deficient in the Insulin-regulated Membrane Aminopeptidase Show Substantial Decreases in Glucose Transporter GLUT4 Levels but Maintain Normal Glucose Homeostasis

The insulin-regulated aminopeptidase (IRAP) is a zinc-dependent membrane aminopeptidase. It is the homologue of the human placental leucine aminopeptidase. In fat and muscle cells, IRAP colocalizes with the insulin-responsive glucose transporter GLUT4 in intracellular vesicles and redistributes to t...

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Veröffentlicht in:	The Journal of biological chemistry 2002-05, Vol.277 (20), p.17677-17686
Hauptverfasser:	Keller, Susanna R., Davis, Ann C., Clairmont, Kevin B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipocytes - metabolism Aminopeptidases - deficiency Aminopeptidases - genetics Aminopeptidases - metabolism Animals Blood Glucose - metabolism Body Weight Cystinyl Aminopeptidase Female Glucose - physiology Glucose Transporter Type 1 Glucose Transporter Type 4 GLUT4 protein Homeostasis Insulin - blood Insulin - physiology insulin-regulated membrane aminopeptidase IRAP gene Male Mice Monosaccharide Transport Proteins - metabolism Muscle Proteins Muscle, Skeletal - metabolism
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