Production of human monoclonal and polyclonal antibodies in TransChromo animals

We have developed TransChromo (TC) technology, which enables the introduction of megabase-sized segments of DNA into cells. We have used this approach to derive mice that carry megabases of human DNA by the use of a human chromosome fragment (HCF) as a vector. TC technology has been applied to the c...

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Veröffentlicht in:	Cloning and stem cells 2002, Vol.4 (1), p.91-102
Hauptverfasser:	Ishida, Isao, Tomizuka, Kazuma, Yoshida, Hitoshi, Tahara, Tomoyuki, Takahashi, Nobuaki, Ohguma, Atsuko, Tanaka, Sonoko, Umehashi, Misako, Maeda, Hiroaki, Nozaki, Chikateru, Halk, Ed, Lonberg, Nils
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified Antibodies, Monoclonal - biosynthesis Genetic Engineering Humans Immunoglobulins - metabolism Mice Mice, Knockout Mice, Transgenic Models, Genetic
Online-Zugang:	Volltext
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