Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification
Department of Pharmacology and Toxicology, Cardiovascular Research Institute Maastricht, Universiteit Maastricht, Maastricht, 6200 MD, The Netherlands Control of blood pressure and of blood flow is essential for maintenance of homeostasis. The hemodynamic state is adjusted by intrinsic, neural, and...
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| Veröffentlicht in: | American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2002-06, Vol.282 (6), p.1545-R1564 |
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| container_end_page | R1564 |
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| container_issue | 6 |
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| container_title | American journal of physiology. Regulatory, integrative and comparative physiology |
| container_volume | 282 |
| creator | Janssen, Ben J. A Smits, Jos F. M |
| description | Department of Pharmacology and Toxicology, Cardiovascular
Research Institute Maastricht, Universiteit Maastricht, Maastricht,
6200 MD, The Netherlands
Control of blood pressure and of
blood flow is essential for maintenance of homeostasis. The hemodynamic
state is adjusted by intrinsic, neural, and hormonal mechanisms to
optimize adaptation to internal and environmental challenges. In the
last decade, many studies showed that modification of the mouse genome
may alter the capacity of cardiovascular control systems to respond to
homeostatic challenges or even bring about a permanent
pathophysiological state. This review discusses the progress that has
been made in understanding of autonomic cardiovascular control
mechanisms from studies in genetically modified mice. First, from a
physiological perspective, we describe how basic hemodynamic function
can be measured in conscious conditions in mice. Second, we focus on the integrative role of autonomic nerves in control of blood pressure in the mouse, and finally, we depict the opportunities and insights provided by genetic modification in this area.
autonomic nervous system; hemodynamic control mechanisms; adrenergic receptors |
| doi_str_mv | 10.1152/ajpregu.00714.2001 |
| format | Article |
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Research Institute Maastricht, Universiteit Maastricht, Maastricht,
6200 MD, The Netherlands
Control of blood pressure and of
blood flow is essential for maintenance of homeostasis. The hemodynamic
state is adjusted by intrinsic, neural, and hormonal mechanisms to
optimize adaptation to internal and environmental challenges. In the
last decade, many studies showed that modification of the mouse genome
may alter the capacity of cardiovascular control systems to respond to
homeostatic challenges or even bring about a permanent
pathophysiological state. This review discusses the progress that has
been made in understanding of autonomic cardiovascular control
mechanisms from studies in genetically modified mice. First, from a
physiological perspective, we describe how basic hemodynamic function
can be measured in conscious conditions in mice. Second, we focus on the integrative role of autonomic nerves in control of blood pressure in the mouse, and finally, we depict the opportunities and insights provided by genetic modification in this area.
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Research Institute Maastricht, Universiteit Maastricht, Maastricht,
6200 MD, The Netherlands
Control of blood pressure and of
blood flow is essential for maintenance of homeostasis. The hemodynamic
state is adjusted by intrinsic, neural, and hormonal mechanisms to
optimize adaptation to internal and environmental challenges. In the
last decade, many studies showed that modification of the mouse genome
may alter the capacity of cardiovascular control systems to respond to
homeostatic challenges or even bring about a permanent
pathophysiological state. This review discusses the progress that has
been made in understanding of autonomic cardiovascular control
mechanisms from studies in genetically modified mice. First, from a
physiological perspective, we describe how basic hemodynamic function
can be measured in conscious conditions in mice. Second, we focus on the integrative role of autonomic nerves in control of blood pressure in the mouse, and finally, we depict the opportunities and insights provided by genetic modification in this area.
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Research Institute Maastricht, Universiteit Maastricht, Maastricht,
6200 MD, The Netherlands
Control of blood pressure and of
blood flow is essential for maintenance of homeostasis. The hemodynamic
state is adjusted by intrinsic, neural, and hormonal mechanisms to
optimize adaptation to internal and environmental challenges. In the
last decade, many studies showed that modification of the mouse genome
may alter the capacity of cardiovascular control systems to respond to
homeostatic challenges or even bring about a permanent
pathophysiological state. This review discusses the progress that has
been made in understanding of autonomic cardiovascular control
mechanisms from studies in genetically modified mice. First, from a
physiological perspective, we describe how basic hemodynamic function
can be measured in conscious conditions in mice. Second, we focus on the integrative role of autonomic nerves in control of blood pressure in the mouse, and finally, we depict the opportunities and insights provided by genetic modification in this area.
autonomic nervous system; hemodynamic control mechanisms; adrenergic receptors</abstract><cop>United States</cop><pmid>12010736</pmid><doi>10.1152/ajpregu.00714.2001</doi></addata></record> |
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| identifier | ISSN: 0363-6119 |
| ispartof | American journal of physiology. Regulatory, integrative and comparative physiology, 2002-06, Vol.282 (6), p.1545-R1564 |
| issn | 0363-6119 1522-1490 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71679074 |
| source | MEDLINE; American Physiological Society; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Autonomic Nervous System - drug effects Autonomic Nervous System - physiology Biological Clocks - physiology Blood Pressure - genetics Blood Pressure - physiology Catecholamines - blood Electrocardiography Ganglionic Blockers - pharmacology Hemodynamics - genetics Hemodynamics - physiology Internet Mice Mice, Knockout Mice, Transgenic Receptors, Adrenergic - physiology Sympathetic Nervous System - physiology |
| title | Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification |
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