MMP-2 sensitive, VEGF-bearing bioactive hydrogels for promotion of vascular healing

We sought to develop bioactive hydrogels to facilitate arterial healing, e.g., after balloon angioplasty. Toward this end, we developed a new class of proteolytically sensitive, biologically active polyethylene glycol (PEG)‐peptide hydrogels that can be formed in situ to temporarily protect the arte...

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Veröffentlicht in:	Journal of biomedical materials research 2004-03, Vol.68A (4), p.704-716
Hauptverfasser:	Seliktar, D., Zisch, A. H., Lutolf, M. P., Wrana, J. L., Hubbell, J. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	arterial injury Arteries - injuries Biocompatible Materials - metabolism Cell Adhesion - physiology endothelial cells Endothelial Cells - physiology enzymatic degradation Humans Hydrogels - metabolism matrix metalloproteinase (MMP) Matrix Metalloproteinase 2 - metabolism polyethylene glycol Time Factors Vascular Endothelial Growth Factor A - metabolism
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