Fluorine-18 fluorodeoxyglucose positron emission tomography predicts lymph node metastasis, P-glycoprotein expression, and recurrence after resection in mass-forming intrahepatic cholangiocarcinoma
Background Patients with intrahepatic cholangiocarcinoma (ICC) have a poor prognosis, and lymph node metastasis is an important prognostic factor. In this study, we investigated the usefulness of fluorodeoxyglucose positron emission tomography (FDG-PET) as a marker for lymph node metastasis, P-glyco...
Gespeichert in:
| Veröffentlicht in: | Surgery 2008-06, Vol.143 (6), p.769-777 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 777 |
|---|---|
| container_issue | 6 |
| container_start_page | 769 |
| container_title | Surgery |
| container_volume | 143 |
| creator | Seo, Satoru, MD Hatano, Etsuro, MD Higashi, Tatsuya, MD Nakajima, Akio, MD Nakamoto, Yuji, MD Tada, Masaharu, MD Tamaki, Nobuyuki, MD Iwaisako, Keiko, MD Mori, Akira, MD Doi, Ryuichiro, MD Ikai, Iwao, MD Uemoto, Shinji, MD |
| description | Background Patients with intrahepatic cholangiocarcinoma (ICC) have a poor prognosis, and lymph node metastasis is an important prognostic factor. In this study, we investigated the usefulness of fluorodeoxyglucose positron emission tomography (FDG-PET) as a marker for lymph node metastasis, P-glycoprotein (P-gp) expression, and recurrence in ICC. Methods The subjects were 35 patients who underwent FDG-PET. Detectability of lymph node metastasis using FDG-PET was compared with that using computed tomography (CT) or magnetic resonance imaging (MRI). In patients who underwent resection, expression of P-gp was examined immunohistochemically, and the relationship between P-gp expression and the standardized uptake value (SUV) in FDG-PET was investigated. Survival rates were analyzed using clinical and pathologic factors. Results Of the 35 patients, 5 did not undergo surgery based on FDG-PET findings (2 with extrahepatic metastasis, and 3 with para-aortic lymph node metastasis) and 3 underwent laparotomy only (2 with peritoneal dissemination and 1 with para-aortic lymph node metastasis). The diagnostic accuracies of FDG-PET, CT, and MRI for detection of lymph node metastasis were 86%, 68%, and 57%, the sensitivities were 43%, 43% and 43%, and the specificities were 100%, 76%, and 64%, respectively. A negative correlation was found between SUV and P-gp expression ( P = .002; r = −0.62). The disease-free survival rates in the high SUV group (≥8.5) were significantly lower than in the low SUV group ( |
| doi_str_mv | 10.1016/j.surg.2008.01.010 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71678341</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S003960600800161X</els_id><sourcerecordid>71678341</sourcerecordid><originalsourceid>FETCH-LOGICAL-c505t-e74b483792b48d4877a5d6d9101ccd3f5f1a9e7676625bca1cc90c39e2ef0b043</originalsourceid><addsrcrecordid>eNp9UtuK1EAQDaK4s6s_4IP0iz5txurcAyLIsqvCgoIKvjU9nUqmxySd7erI5gP9LyvOoOCDUNAXzjlVfU5H0TMJWwmyeHXY0uy7bQJQbUFywYNoI_M0icu0kA-jDUBaxwUUcBadEx0AoM5k9Tg6k1We1VWdbqKfN_3svB0xlpVo171r0N0vXT8bRygmRzZ4NwocLJHlTXCD67ye9ouYPDbWBBL9Mkx7MTJVDBg0cVm6FJ_irl-Mm7wLaFningm_RS6FHhvh0cze42hQ6Dag5wtCE9YmjB40Udw6P9ix43Pweo-TDtYIs3e9HjvrjPbGjm7QT6JHre4Jn57Wi-jrzfWXq_fx7cd3H67e3sYmhzzEWGa7rErLOuGlyaqy1HlTNDW7aUyTtnkrdY1lURZFku-M5tsaTFpjgi3sIEsvopdHXX7S3YwUFLtisOdx0M2kSlmUVZpJBiZHoPGOyGOrJm8H7RclQa3hqYNaw1NreAokFzDp-Ul93g3Y_KWc0mLAixNAk9F96_VoLP3BJZDlZZ5XjHt9xCF78cOiV2Ts6nNj2fOgGmf_P8ebf-imt6Pljt9xQTq42Y_sspKKEgXq8_rN1l8GFbCi_Jb-AkK-1Ho</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>71678341</pqid></control><display><type>article</type><title>Fluorine-18 fluorodeoxyglucose positron emission tomography predicts lymph node metastasis, P-glycoprotein expression, and recurrence after resection in mass-forming intrahepatic cholangiocarcinoma</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Seo, Satoru, MD ; Hatano, Etsuro, MD ; Higashi, Tatsuya, MD ; Nakajima, Akio, MD ; Nakamoto, Yuji, MD ; Tada, Masaharu, MD ; Tamaki, Nobuyuki, MD ; Iwaisako, Keiko, MD ; Mori, Akira, MD ; Doi, Ryuichiro, MD ; Ikai, Iwao, MD ; Uemoto, Shinji, MD</creator><creatorcontrib>Seo, Satoru, MD ; Hatano, Etsuro, MD ; Higashi, Tatsuya, MD ; Nakajima, Akio, MD ; Nakamoto, Yuji, MD ; Tada, Masaharu, MD ; Tamaki, Nobuyuki, MD ; Iwaisako, Keiko, MD ; Mori, Akira, MD ; Doi, Ryuichiro, MD ; Ikai, Iwao, MD ; Uemoto, Shinji, MD</creatorcontrib><description>Background Patients with intrahepatic cholangiocarcinoma (ICC) have a poor prognosis, and lymph node metastasis is an important prognostic factor. In this study, we investigated the usefulness of fluorodeoxyglucose positron emission tomography (FDG-PET) as a marker for lymph node metastasis, P-glycoprotein (P-gp) expression, and recurrence in ICC. Methods The subjects were 35 patients who underwent FDG-PET. Detectability of lymph node metastasis using FDG-PET was compared with that using computed tomography (CT) or magnetic resonance imaging (MRI). In patients who underwent resection, expression of P-gp was examined immunohistochemically, and the relationship between P-gp expression and the standardized uptake value (SUV) in FDG-PET was investigated. Survival rates were analyzed using clinical and pathologic factors. Results Of the 35 patients, 5 did not undergo surgery based on FDG-PET findings (2 with extrahepatic metastasis, and 3 with para-aortic lymph node metastasis) and 3 underwent laparotomy only (2 with peritoneal dissemination and 1 with para-aortic lymph node metastasis). The diagnostic accuracies of FDG-PET, CT, and MRI for detection of lymph node metastasis were 86%, 68%, and 57%, the sensitivities were 43%, 43% and 43%, and the specificities were 100%, 76%, and 64%, respectively. A negative correlation was found between SUV and P-gp expression ( P = .002; r = −0.62). The disease-free survival rates in the high SUV group (≥8.5) were significantly lower than in the low SUV group (<8.5; P = .04), and a high SUV was an independent predictor of postoperative recurrence in multivariate analysis (risk ratio, 1.3; P = .03). Conclusions FDG-PET is useful for prediction of lymph node metastasis, P-gp expression and recurrence in ICC.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/j.surg.2008.01.010</identifier><identifier>PMID: 18549893</identifier><identifier>CODEN: SURGAZ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Adult ; Aged ; ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ; ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism ; Bile Duct Neoplasms - complications ; Bile Duct Neoplasms - surgery ; Bile Ducts, Intrahepatic - surgery ; Biological and medical sciences ; Cholangiocarcinoma - complications ; Cholangiocarcinoma - surgery ; Female ; Fluorodeoxyglucose F18 ; Gene Expression Regulation, Neoplastic ; General aspects ; Hematologic and hematopoietic diseases ; Humans ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Lymphatic Metastasis - diagnostic imaging ; Lymphatic Metastasis - pathology ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Neoplasm Recurrence, Local - diagnostic imaging ; Neoplasm Recurrence, Local - etiology ; Neoplasm Recurrence, Local - pathology ; Positron-Emission Tomography - methods ; Prognosis ; Risk Factors ; Sensitivity and Specificity ; Surgery ; Tomography, Emission-Computed</subject><ispartof>Surgery, 2008-06, Vol.143 (6), p.769-777</ispartof><rights>Mosby, Inc.</rights><rights>2008 Mosby, Inc.</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-e74b483792b48d4877a5d6d9101ccd3f5f1a9e7676625bca1cc90c39e2ef0b043</citedby><cites>FETCH-LOGICAL-c505t-e74b483792b48d4877a5d6d9101ccd3f5f1a9e7676625bca1cc90c39e2ef0b043</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.surg.2008.01.010$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20457558$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18549893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Seo, Satoru, MD</creatorcontrib><creatorcontrib>Hatano, Etsuro, MD</creatorcontrib><creatorcontrib>Higashi, Tatsuya, MD</creatorcontrib><creatorcontrib>Nakajima, Akio, MD</creatorcontrib><creatorcontrib>Nakamoto, Yuji, MD</creatorcontrib><creatorcontrib>Tada, Masaharu, MD</creatorcontrib><creatorcontrib>Tamaki, Nobuyuki, MD</creatorcontrib><creatorcontrib>Iwaisako, Keiko, MD</creatorcontrib><creatorcontrib>Mori, Akira, MD</creatorcontrib><creatorcontrib>Doi, Ryuichiro, MD</creatorcontrib><creatorcontrib>Ikai, Iwao, MD</creatorcontrib><creatorcontrib>Uemoto, Shinji, MD</creatorcontrib><title>Fluorine-18 fluorodeoxyglucose positron emission tomography predicts lymph node metastasis, P-glycoprotein expression, and recurrence after resection in mass-forming intrahepatic cholangiocarcinoma</title><title>Surgery</title><addtitle>Surgery</addtitle><description>Background Patients with intrahepatic cholangiocarcinoma (ICC) have a poor prognosis, and lymph node metastasis is an important prognostic factor. In this study, we investigated the usefulness of fluorodeoxyglucose positron emission tomography (FDG-PET) as a marker for lymph node metastasis, P-glycoprotein (P-gp) expression, and recurrence in ICC. Methods The subjects were 35 patients who underwent FDG-PET. Detectability of lymph node metastasis using FDG-PET was compared with that using computed tomography (CT) or magnetic resonance imaging (MRI). In patients who underwent resection, expression of P-gp was examined immunohistochemically, and the relationship between P-gp expression and the standardized uptake value (SUV) in FDG-PET was investigated. Survival rates were analyzed using clinical and pathologic factors. Results Of the 35 patients, 5 did not undergo surgery based on FDG-PET findings (2 with extrahepatic metastasis, and 3 with para-aortic lymph node metastasis) and 3 underwent laparotomy only (2 with peritoneal dissemination and 1 with para-aortic lymph node metastasis). The diagnostic accuracies of FDG-PET, CT, and MRI for detection of lymph node metastasis were 86%, 68%, and 57%, the sensitivities were 43%, 43% and 43%, and the specificities were 100%, 76%, and 64%, respectively. A negative correlation was found between SUV and P-gp expression ( P = .002; r = −0.62). The disease-free survival rates in the high SUV group (≥8.5) were significantly lower than in the low SUV group (<8.5; P = .04), and a high SUV was an independent predictor of postoperative recurrence in multivariate analysis (risk ratio, 1.3; P = .03). Conclusions FDG-PET is useful for prediction of lymph node metastasis, P-gp expression and recurrence in ICC.</description><subject>Adult</subject><subject>Aged</subject><subject>ATP-Binding Cassette, Sub-Family B, Member 1 - genetics</subject><subject>ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism</subject><subject>Bile Duct Neoplasms - complications</subject><subject>Bile Duct Neoplasms - surgery</subject><subject>Bile Ducts, Intrahepatic - surgery</subject><subject>Biological and medical sciences</subject><subject>Cholangiocarcinoma - complications</subject><subject>Cholangiocarcinoma - surgery</subject><subject>Female</subject><subject>Fluorodeoxyglucose F18</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>General aspects</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Lymphatic Metastasis - diagnostic imaging</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neoplasm Recurrence, Local - diagnostic imaging</subject><subject>Neoplasm Recurrence, Local - etiology</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Positron-Emission Tomography - methods</subject><subject>Prognosis</subject><subject>Risk Factors</subject><subject>Sensitivity and Specificity</subject><subject>Surgery</subject><subject>Tomography, Emission-Computed</subject><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UtuK1EAQDaK4s6s_4IP0iz5txurcAyLIsqvCgoIKvjU9nUqmxySd7erI5gP9LyvOoOCDUNAXzjlVfU5H0TMJWwmyeHXY0uy7bQJQbUFywYNoI_M0icu0kA-jDUBaxwUUcBadEx0AoM5k9Tg6k1We1VWdbqKfN_3svB0xlpVo171r0N0vXT8bRygmRzZ4NwocLJHlTXCD67ye9ouYPDbWBBL9Mkx7MTJVDBg0cVm6FJ_irl-Mm7wLaFningm_RS6FHhvh0cze42hQ6Dag5wtCE9YmjB40Udw6P9ix43Pweo-TDtYIs3e9HjvrjPbGjm7QT6JHre4Jn57Wi-jrzfWXq_fx7cd3H67e3sYmhzzEWGa7rErLOuGlyaqy1HlTNDW7aUyTtnkrdY1lURZFku-M5tsaTFpjgi3sIEsvopdHXX7S3YwUFLtisOdx0M2kSlmUVZpJBiZHoPGOyGOrJm8H7RclQa3hqYNaw1NreAokFzDp-Ul93g3Y_KWc0mLAixNAk9F96_VoLP3BJZDlZZ5XjHt9xCF78cOiV2Ts6nNj2fOgGmf_P8ebf-imt6Pljt9xQTq42Y_sspKKEgXq8_rN1l8GFbCi_Jb-AkK-1Ho</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Seo, Satoru, MD</creator><creator>Hatano, Etsuro, MD</creator><creator>Higashi, Tatsuya, MD</creator><creator>Nakajima, Akio, MD</creator><creator>Nakamoto, Yuji, MD</creator><creator>Tada, Masaharu, MD</creator><creator>Tamaki, Nobuyuki, MD</creator><creator>Iwaisako, Keiko, MD</creator><creator>Mori, Akira, MD</creator><creator>Doi, Ryuichiro, MD</creator><creator>Ikai, Iwao, MD</creator><creator>Uemoto, Shinji, MD</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080601</creationdate><title>Fluorine-18 fluorodeoxyglucose positron emission tomography predicts lymph node metastasis, P-glycoprotein expression, and recurrence after resection in mass-forming intrahepatic cholangiocarcinoma</title><author>Seo, Satoru, MD ; Hatano, Etsuro, MD ; Higashi, Tatsuya, MD ; Nakajima, Akio, MD ; Nakamoto, Yuji, MD ; Tada, Masaharu, MD ; Tamaki, Nobuyuki, MD ; Iwaisako, Keiko, MD ; Mori, Akira, MD ; Doi, Ryuichiro, MD ; Ikai, Iwao, MD ; Uemoto, Shinji, MD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-e74b483792b48d4877a5d6d9101ccd3f5f1a9e7676625bca1cc90c39e2ef0b043</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>ATP-Binding Cassette, Sub-Family B, Member 1 - genetics</topic><topic>ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism</topic><topic>Bile Duct Neoplasms - complications</topic><topic>Bile Duct Neoplasms - surgery</topic><topic>Bile Ducts, Intrahepatic - surgery</topic><topic>Biological and medical sciences</topic><topic>Cholangiocarcinoma - complications</topic><topic>Cholangiocarcinoma - surgery</topic><topic>Female</topic><topic>Fluorodeoxyglucose F18</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>General aspects</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Lymphatic Metastasis - diagnostic imaging</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neoplasm Recurrence, Local - diagnostic imaging</topic><topic>Neoplasm Recurrence, Local - etiology</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Positron-Emission Tomography - methods</topic><topic>Prognosis</topic><topic>Risk Factors</topic><topic>Sensitivity and Specificity</topic><topic>Surgery</topic><topic>Tomography, Emission-Computed</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Seo, Satoru, MD</creatorcontrib><creatorcontrib>Hatano, Etsuro, MD</creatorcontrib><creatorcontrib>Higashi, Tatsuya, MD</creatorcontrib><creatorcontrib>Nakajima, Akio, MD</creatorcontrib><creatorcontrib>Nakamoto, Yuji, MD</creatorcontrib><creatorcontrib>Tada, Masaharu, MD</creatorcontrib><creatorcontrib>Tamaki, Nobuyuki, MD</creatorcontrib><creatorcontrib>Iwaisako, Keiko, MD</creatorcontrib><creatorcontrib>Mori, Akira, MD</creatorcontrib><creatorcontrib>Doi, Ryuichiro, MD</creatorcontrib><creatorcontrib>Ikai, Iwao, MD</creatorcontrib><creatorcontrib>Uemoto, Shinji, MD</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Seo, Satoru, MD</au><au>Hatano, Etsuro, MD</au><au>Higashi, Tatsuya, MD</au><au>Nakajima, Akio, MD</au><au>Nakamoto, Yuji, MD</au><au>Tada, Masaharu, MD</au><au>Tamaki, Nobuyuki, MD</au><au>Iwaisako, Keiko, MD</au><au>Mori, Akira, MD</au><au>Doi, Ryuichiro, MD</au><au>Ikai, Iwao, MD</au><au>Uemoto, Shinji, MD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fluorine-18 fluorodeoxyglucose positron emission tomography predicts lymph node metastasis, P-glycoprotein expression, and recurrence after resection in mass-forming intrahepatic cholangiocarcinoma</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>143</volume><issue>6</issue><spage>769</spage><epage>777</epage><pages>769-777</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><coden>SURGAZ</coden><abstract>Background Patients with intrahepatic cholangiocarcinoma (ICC) have a poor prognosis, and lymph node metastasis is an important prognostic factor. In this study, we investigated the usefulness of fluorodeoxyglucose positron emission tomography (FDG-PET) as a marker for lymph node metastasis, P-glycoprotein (P-gp) expression, and recurrence in ICC. Methods The subjects were 35 patients who underwent FDG-PET. Detectability of lymph node metastasis using FDG-PET was compared with that using computed tomography (CT) or magnetic resonance imaging (MRI). In patients who underwent resection, expression of P-gp was examined immunohistochemically, and the relationship between P-gp expression and the standardized uptake value (SUV) in FDG-PET was investigated. Survival rates were analyzed using clinical and pathologic factors. Results Of the 35 patients, 5 did not undergo surgery based on FDG-PET findings (2 with extrahepatic metastasis, and 3 with para-aortic lymph node metastasis) and 3 underwent laparotomy only (2 with peritoneal dissemination and 1 with para-aortic lymph node metastasis). The diagnostic accuracies of FDG-PET, CT, and MRI for detection of lymph node metastasis were 86%, 68%, and 57%, the sensitivities were 43%, 43% and 43%, and the specificities were 100%, 76%, and 64%, respectively. A negative correlation was found between SUV and P-gp expression ( P = .002; r = −0.62). The disease-free survival rates in the high SUV group (≥8.5) were significantly lower than in the low SUV group (<8.5; P = .04), and a high SUV was an independent predictor of postoperative recurrence in multivariate analysis (risk ratio, 1.3; P = .03). Conclusions FDG-PET is useful for prediction of lymph node metastasis, P-gp expression and recurrence in ICC.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>18549893</pmid><doi>10.1016/j.surg.2008.01.010</doi><tpages>9</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0039-6060 |
| ispartof | Surgery, 2008-06, Vol.143 (6), p.769-777 |
| issn | 0039-6060 1532-7361 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_71678341 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult Aged ATP-Binding Cassette, Sub-Family B, Member 1 - genetics ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Bile Duct Neoplasms - complications Bile Duct Neoplasms - surgery Bile Ducts, Intrahepatic - surgery Biological and medical sciences Cholangiocarcinoma - complications Cholangiocarcinoma - surgery Female Fluorodeoxyglucose F18 Gene Expression Regulation, Neoplastic General aspects Hematologic and hematopoietic diseases Humans Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Lymphatic Metastasis - diagnostic imaging Lymphatic Metastasis - pathology Magnetic Resonance Imaging Male Medical sciences Middle Aged Multivariate Analysis Neoplasm Recurrence, Local - diagnostic imaging Neoplasm Recurrence, Local - etiology Neoplasm Recurrence, Local - pathology Positron-Emission Tomography - methods Prognosis Risk Factors Sensitivity and Specificity Surgery Tomography, Emission-Computed |
| title | Fluorine-18 fluorodeoxyglucose positron emission tomography predicts lymph node metastasis, P-glycoprotein expression, and recurrence after resection in mass-forming intrahepatic cholangiocarcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T11%3A14%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fluorine-18%20fluorodeoxyglucose%20positron%20emission%20tomography%20predicts%20lymph%20node%20metastasis,%20P-glycoprotein%20expression,%20and%20recurrence%20after%20resection%20in%20mass-forming%20intrahepatic%20cholangiocarcinoma&rft.jtitle=Surgery&rft.au=Seo,%20Satoru,%20MD&rft.date=2008-06-01&rft.volume=143&rft.issue=6&rft.spage=769&rft.epage=777&rft.pages=769-777&rft.issn=0039-6060&rft.eissn=1532-7361&rft.coden=SURGAZ&rft_id=info:doi/10.1016/j.surg.2008.01.010&rft_dat=%3Cproquest_cross%3E71678341%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=71678341&rft_id=info:pmid/18549893&rft_els_id=S003960600800161X&rfr_iscdi=true |