A novel mechanism of factor VIII protection by von Willebrand factor from activated protein C–catalyzed inactivation

The protective effect of von Willebrand factor (VWF) toward activated protein C (APC)–catalyzed inactivation of factor VIII (FVIII) has been attributed mainly to inhibition of FVIII binding to phospholipid. In the present study, we demonstrated that VWF-mediated FVIII protection from APC also result...

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Veröffentlicht in:	Blood 2002-06, Vol.99 (11), p.3993-3998
Hauptverfasser:	Nogami, Keiji, Shima, Midori, Nishiya, Katsumi, Hosokawa, Kazuya, Saenko, Evgueni L., Sakurai, Yoshihiko, Shibata, Masaru, Suzuki, Hiroshi, Tanaka, Ichiro, Yoshioka, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Monoclonal Binding Sites Biological and medical sciences Cell metabolism, cell oxidation Cell physiology Epitopes - chemistry Epitopes - metabolism Factor VIII - antagonists & inhibitors Factor VIII - physiology Fundamental and applied biological sciences. Psychology Humans Immunoglobulin G - chemistry Kinetics Molecular and cellular biology Molecular Sequence Data Peptide Fragments - antagonists & inhibitors Peptide Fragments - chemistry Peptide Fragments - metabolism Protein Binding Protein C Inhibitor - metabolism Rabbits von Willebrand Factor - metabolism
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