SOS-NMR:  A Saturation Transfer NMR-Based Method for Determining the Structures of Protein−Ligand Complexes

An NMR-based alternative to traditional X-ray crystallography and NMR methods for structure-based drug design is described that enables the structure determination of ligands complexed to virtually any biomolecular target regardless of size, composition, or oligomeric state. The method utilizes satu...

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Veröffentlicht in:	Journal of the American Chemical Society 2004-03, Vol.126 (8), p.2390-2398
Hauptverfasser:	Hajduk, Philip J, Mack, Jamey C, Olejniczak, Edward T, Park, Chang, Dandliker, Peter J, Beutel, Bruce A
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkyl and Aryl Transferases - chemistry Benzimidazoles - chemistry Binding Sites Biological and medical sciences Crystallography, X-Ray Fundamental and applied biological sciences. Psychology Interactions. Associations Intermolecular phenomena Models, Molecular Molecular biophysics Nuclear Magnetic Resonance, Biomolecular - methods Protein Conformation Tacrolimus Binding Proteins - chemistry Thermodynamics Uridine Diphosphate N-Acetylglucosamine - chemistry
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