Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro
Schizonepeta tenuifolia (ST) is a major herbal constituent included in treatments for the common cold with fever, ostitis media and other skin inflammations. The present study investigated the effect of ST water extract on the pattern of cytokine production from activated T cells in‐vivo and in‐vitr...
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| Veröffentlicht in: | Journal of pharmacy and pharmacology 2008-07, Vol.60 (7), p.901-907 |
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| creator | Kang, Hee Oh, Yoo-Joung Choi, Ho-Young Ham, In-Hye Bae, Hyun-Su Kim, Sung-Hoon Ahn, Kyoo-Seok |
| description | Schizonepeta tenuifolia (ST) is a major herbal constituent included in treatments for the common cold with fever, ostitis media and other skin inflammations. The present study investigated the effect of ST water extract on the pattern of cytokine production from activated T cells in‐vivo and in‐vitro. When ST (200 mgkg−1) was given orally to mice for 7 days before i.v. injection of anti‐CD3 antibody, it significantly decreased mRNA levels of interleukin (IL)‐4, interferon (IFN)‐γ and T‐bet. Our flow cytometric analysis showed that ST administration significantly increased CD69 expression but showed little effect on the subsets of T cells. When we cultured mouse CD4 T cells under Th1/Th2 differentiation in the presence of ST, the suppressive activity of ST on IFN‐γ involved T‐bet, but the downregulation of IL‐4 occurred independently of the Th2 transcription factors GATA binding protein 3 (GATA‐3) and c‐Maf. However, it increased IL‐2 secretion during Th1/Th2 differentiation. Our study demonstrates that ST regulates inflammatory responses by reducing the release of Th1 and Th2 cytokines from T cells and prevents unprimed CD4 T cells from differentiating into Th1 and Th2 cells. |
| doi_str_mv | 10.1211/jpp.60.7.0012 |
| format | Article |
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The present study investigated the effect of ST water extract on the pattern of cytokine production from activated T cells in‐vivo and in‐vitro. When ST (200 mgkg−1) was given orally to mice for 7 days before i.v. injection of anti‐CD3 antibody, it significantly decreased mRNA levels of interleukin (IL)‐4, interferon (IFN)‐γ and T‐bet. Our flow cytometric analysis showed that ST administration significantly increased CD69 expression but showed little effect on the subsets of T cells. When we cultured mouse CD4 T cells under Th1/Th2 differentiation in the presence of ST, the suppressive activity of ST on IFN‐γ involved T‐bet, but the downregulation of IL‐4 occurred independently of the Th2 transcription factors GATA binding protein 3 (GATA‐3) and c‐Maf. However, it increased IL‐2 secretion during Th1/Th2 differentiation. Our study demonstrates that ST regulates inflammatory responses by reducing the release of Th1 and Th2 cytokines from T cells and prevents unprimed CD4 T cells from differentiating into Th1 and Th2 cells.</description><identifier>ISSN: 0022-3573</identifier><identifier>EISSN: 2042-7158</identifier><identifier>DOI: 10.1211/jpp.60.7.0012</identifier><identifier>PMID: 18549677</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Animals ; CD3 Complex - immunology ; Cell Differentiation - drug effects ; Female ; Immunologic Factors - pharmacology ; Interferon-gamma - biosynthesis ; Interleukin-4 - biosynthesis ; Lamiaceae - chemistry ; Lymphocyte Activation - drug effects ; Mice ; Mice, Inbred BALB C ; Monoterpenes - analysis ; Plant Extracts - analysis ; Plant Extracts - pharmacology ; Th1 Cells - drug effects ; Th1 Cells - immunology ; Th2 Cells - drug effects ; Th2 Cells - immunology</subject><ispartof>Journal of pharmacy and pharmacology, 2008-07, Vol.60 (7), p.901-907</ispartof><rights>2008 Royal Pharmaceutical Society of Great Britain</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4434-49dea84f17102169738535bed659a49fdfae303c330d38c0d94cfc23c845e8d33</citedby><cites>FETCH-LOGICAL-c4434-49dea84f17102169738535bed659a49fdfae303c330d38c0d94cfc23c845e8d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1211%2Fjpp.60.7.0012$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1211%2Fjpp.60.7.0012$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18549677$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kang, Hee</creatorcontrib><creatorcontrib>Oh, Yoo-Joung</creatorcontrib><creatorcontrib>Choi, Ho-Young</creatorcontrib><creatorcontrib>Ham, In-Hye</creatorcontrib><creatorcontrib>Bae, Hyun-Su</creatorcontrib><creatorcontrib>Kim, Sung-Hoon</creatorcontrib><creatorcontrib>Ahn, Kyoo-Seok</creatorcontrib><title>Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro</title><title>Journal of pharmacy and pharmacology</title><addtitle>J Pharm Pharmacol</addtitle><description>Schizonepeta tenuifolia (ST) is a major herbal constituent included in treatments for the common cold with fever, ostitis media and other skin inflammations. The present study investigated the effect of ST water extract on the pattern of cytokine production from activated T cells in‐vivo and in‐vitro. When ST (200 mgkg−1) was given orally to mice for 7 days before i.v. injection of anti‐CD3 antibody, it significantly decreased mRNA levels of interleukin (IL)‐4, interferon (IFN)‐γ and T‐bet. Our flow cytometric analysis showed that ST administration significantly increased CD69 expression but showed little effect on the subsets of T cells. When we cultured mouse CD4 T cells under Th1/Th2 differentiation in the presence of ST, the suppressive activity of ST on IFN‐γ involved T‐bet, but the downregulation of IL‐4 occurred independently of the Th2 transcription factors GATA binding protein 3 (GATA‐3) and c‐Maf. However, it increased IL‐2 secretion during Th1/Th2 differentiation. Our study demonstrates that ST regulates inflammatory responses by reducing the release of Th1 and Th2 cytokines from T cells and prevents unprimed CD4 T cells from differentiating into Th1 and Th2 cells.</description><subject>Animals</subject><subject>CD3 Complex - immunology</subject><subject>Cell Differentiation - drug effects</subject><subject>Female</subject><subject>Immunologic Factors - pharmacology</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interleukin-4 - biosynthesis</subject><subject>Lamiaceae - chemistry</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Monoterpenes - analysis</subject><subject>Plant Extracts - analysis</subject><subject>Plant Extracts - pharmacology</subject><subject>Th1 Cells - drug effects</subject><subject>Th1 Cells - immunology</subject><subject>Th2 Cells - drug effects</subject><subject>Th2 Cells - immunology</subject><issn>0022-3573</issn><issn>2042-7158</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1P3DAQhq2qVdlCj1wrn3rL4m8nxypqgQq1K7EVvVnGGWsNSZw6DrD8-ma1K7i1p5nDM69ezYPQKSVLyig9uxuGpSJLvSSEsjdowYhghaayfIsWhDBWcKn5EfowjneEEK2Ueo-OaClFpbReoOfLrpv62MVmam2OaYvBe3AZR4-v3SY8xx4GyBZn6KfgYxssfrQZEoannOwO7HEXpxHwekPP1huG3TbH-9ADHtKc6nKYidAXD-EhYts3-z2neILeeduO8PEwj9Gvb1_X9UVx9fP8sv5yVTghuChE1YAthaeaEkZVpXkpubyFRsnKiso33gIn3HFOGl460lTCece4K4WEsuH8GH3e5859_kwwZtOF0UHb2h7m4kZTNb9F_B9ku_-VXM5gsQddiuOYwJshhc6mraHE7KyY2YpRxGizszLznw7B020HzSt90DADfA88hha2_04z31cXK0aJeK0RxgxPL1c23RuluZbm5se5-S2v63pVrwzjfwFzRKku</recordid><startdate>200807</startdate><enddate>200807</enddate><creator>Kang, Hee</creator><creator>Oh, Yoo-Joung</creator><creator>Choi, Ho-Young</creator><creator>Ham, In-Hye</creator><creator>Bae, Hyun-Su</creator><creator>Kim, Sung-Hoon</creator><creator>Ahn, Kyoo-Seok</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200807</creationdate><title>Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro</title><author>Kang, Hee ; Oh, Yoo-Joung ; Choi, Ho-Young ; Ham, In-Hye ; Bae, Hyun-Su ; Kim, Sung-Hoon ; Ahn, Kyoo-Seok</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4434-49dea84f17102169738535bed659a49fdfae303c330d38c0d94cfc23c845e8d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>CD3 Complex - immunology</topic><topic>Cell Differentiation - drug effects</topic><topic>Female</topic><topic>Immunologic Factors - pharmacology</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interleukin-4 - biosynthesis</topic><topic>Lamiaceae - chemistry</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Monoterpenes - analysis</topic><topic>Plant Extracts - analysis</topic><topic>Plant Extracts - pharmacology</topic><topic>Th1 Cells - drug effects</topic><topic>Th1 Cells - immunology</topic><topic>Th2 Cells - drug effects</topic><topic>Th2 Cells - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kang, Hee</creatorcontrib><creatorcontrib>Oh, Yoo-Joung</creatorcontrib><creatorcontrib>Choi, Ho-Young</creatorcontrib><creatorcontrib>Ham, In-Hye</creatorcontrib><creatorcontrib>Bae, Hyun-Su</creatorcontrib><creatorcontrib>Kim, Sung-Hoon</creatorcontrib><creatorcontrib>Ahn, Kyoo-Seok</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacy and pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kang, Hee</au><au>Oh, Yoo-Joung</au><au>Choi, Ho-Young</au><au>Ham, In-Hye</au><au>Bae, Hyun-Su</au><au>Kim, Sung-Hoon</au><au>Ahn, Kyoo-Seok</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro</atitle><jtitle>Journal of pharmacy and pharmacology</jtitle><addtitle>J Pharm Pharmacol</addtitle><date>2008-07</date><risdate>2008</risdate><volume>60</volume><issue>7</issue><spage>901</spage><epage>907</epage><pages>901-907</pages><issn>0022-3573</issn><eissn>2042-7158</eissn><abstract>Schizonepeta tenuifolia (ST) is a major herbal constituent included in treatments for the common cold with fever, ostitis media and other skin inflammations. The present study investigated the effect of ST water extract on the pattern of cytokine production from activated T cells in‐vivo and in‐vitro. When ST (200 mgkg−1) was given orally to mice for 7 days before i.v. injection of anti‐CD3 antibody, it significantly decreased mRNA levels of interleukin (IL)‐4, interferon (IFN)‐γ and T‐bet. Our flow cytometric analysis showed that ST administration significantly increased CD69 expression but showed little effect on the subsets of T cells. When we cultured mouse CD4 T cells under Th1/Th2 differentiation in the presence of ST, the suppressive activity of ST on IFN‐γ involved T‐bet, but the downregulation of IL‐4 occurred independently of the Th2 transcription factors GATA binding protein 3 (GATA‐3) and c‐Maf. However, it increased IL‐2 secretion during Th1/Th2 differentiation. 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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals CD3 Complex - immunology Cell Differentiation - drug effects Female Immunologic Factors - pharmacology Interferon-gamma - biosynthesis Interleukin-4 - biosynthesis Lamiaceae - chemistry Lymphocyte Activation - drug effects Mice Mice, Inbred BALB C Monoterpenes - analysis Plant Extracts - analysis Plant Extracts - pharmacology Th1 Cells - drug effects Th1 Cells - immunology Th2 Cells - drug effects Th2 Cells - immunology |
| title | Immunomodulatory effect of Schizonepeta tenuifolia water extract on mouse Th1/Th2 cytokine production in-vivo and in-vitro |
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