Association between carotid intima-media thickness and low-density lipoprotein size and susceptibility of low-density lipoprotein to oxidation in asymptomatic members of familial combined hyperlipidemia families
In addition to low-density lipoprotein (LDL) cholesterol, small, dense LDL particles and oxidative modification of LDL have been linked to the pathogenesis of atherosclerosis. The present study was aimed at investigating the association between carotid artery intima-media thickness (IMT) and LDL par...
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| Veröffentlicht in: | Stroke (1970) 2002-05, Vol.33 (5), p.1255-1260 |
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| container_title | Stroke (1970) |
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| creator | LIU, Ming-Lin YLITALO, Kati NUOTIO, Ilpo SALONEN, Riitta SALONEN, Jukka T TASKINEN, Marja-Riitta |
| description | In addition to low-density lipoprotein (LDL) cholesterol, small, dense LDL particles and oxidative modification of LDL have been linked to the pathogenesis of atherosclerosis. The present study was aimed at investigating the association between carotid artery intima-media thickness (IMT) and LDL particle size and susceptibility of LDL to oxidation in vitro in asymptomatic members of familial combined hyperlipidemia (FCHL) families.
LDL particle size, susceptibility of LDL to oxidation in vitro, and carotid IMT were measured in 148 asymptomatic FCHL family members.
LDL particle size and lag time for LDL oxidation were reduced in hyperlipidemic compared with normolipidemic family members. LDL particle size, serum total cholesterol, and alpha-tocopherol in LDL were independently associated with lag time for LDL oxidation in multivariate analysis. LDL particle size was associated with carotid mean IMT independently of clinical, lipid, and antioxidant variables in multivariate analysis. Although the susceptibility of LDL to oxidation in vitro was correlated with mean IMT, it did not have a significant independent contribution to variation in mean IMT in the multivariate model.
We conclude that LDL particle size but not susceptibility of LDL to oxidation in vitro is independently associated with carotid IMT in asymptomatic FCHL family members. These results imply that small, dense LDL as an inherent feature of FCHL is an important diagnostic indicator for coronary artery disease risk in FCHL. |
| doi_str_mv | 10.1161/01.str.0000014924.29238.e1 |
| format | Article |
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LDL particle size, susceptibility of LDL to oxidation in vitro, and carotid IMT were measured in 148 asymptomatic FCHL family members.
LDL particle size and lag time for LDL oxidation were reduced in hyperlipidemic compared with normolipidemic family members. LDL particle size, serum total cholesterol, and alpha-tocopherol in LDL were independently associated with lag time for LDL oxidation in multivariate analysis. LDL particle size was associated with carotid mean IMT independently of clinical, lipid, and antioxidant variables in multivariate analysis. Although the susceptibility of LDL to oxidation in vitro was correlated with mean IMT, it did not have a significant independent contribution to variation in mean IMT in the multivariate model.
We conclude that LDL particle size but not susceptibility of LDL to oxidation in vitro is independently associated with carotid IMT in asymptomatic FCHL family members. These results imply that small, dense LDL as an inherent feature of FCHL is an important diagnostic indicator for coronary artery disease risk in FCHL.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.str.0000014924.29238.e1</identifier><identifier>PMID: 11988600</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Antioxidants - analysis ; Biological and medical sciences ; Carotid Arteries - diagnostic imaging ; Carotid Artery Diseases - blood ; Carotid Artery Diseases - diagnostic imaging ; Disorders of blood lipids. Hyperlipoproteinemia ; Female ; Finland ; Humans ; Hyperlipidemia, Familial Combined - blood ; Lipoproteins, LDL - blood ; Lipoproteins, LDL - chemistry ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Multivariate Analysis ; Oxidation-Reduction ; Particle Size ; Predictive Value of Tests ; Risk ; Tunica Intima - diagnostic imaging ; Tunica Media - diagnostic imaging ; Ultrasonography</subject><ispartof>Stroke (1970), 2002-05, Vol.33 (5), p.1255-1260</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. May 2002</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-869c687bea2f42349a7d0735dd1ad333685baab9c993a6b2117f03bb9d865c873</citedby><cites>FETCH-LOGICAL-c526t-869c687bea2f42349a7d0735dd1ad333685baab9c993a6b2117f03bb9d865c873</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3674,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13659562$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11988600$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LIU, Ming-Lin</creatorcontrib><creatorcontrib>YLITALO, Kati</creatorcontrib><creatorcontrib>NUOTIO, Ilpo</creatorcontrib><creatorcontrib>SALONEN, Riitta</creatorcontrib><creatorcontrib>SALONEN, Jukka T</creatorcontrib><creatorcontrib>TASKINEN, Marja-Riitta</creatorcontrib><title>Association between carotid intima-media thickness and low-density lipoprotein size and susceptibility of low-density lipoprotein to oxidation in asymptomatic members of familial combined hyperlipidemia families</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>In addition to low-density lipoprotein (LDL) cholesterol, small, dense LDL particles and oxidative modification of LDL have been linked to the pathogenesis of atherosclerosis. The present study was aimed at investigating the association between carotid artery intima-media thickness (IMT) and LDL particle size and susceptibility of LDL to oxidation in vitro in asymptomatic members of familial combined hyperlipidemia (FCHL) families.
LDL particle size, susceptibility of LDL to oxidation in vitro, and carotid IMT were measured in 148 asymptomatic FCHL family members.
LDL particle size and lag time for LDL oxidation were reduced in hyperlipidemic compared with normolipidemic family members. LDL particle size, serum total cholesterol, and alpha-tocopherol in LDL were independently associated with lag time for LDL oxidation in multivariate analysis. LDL particle size was associated with carotid mean IMT independently of clinical, lipid, and antioxidant variables in multivariate analysis. Although the susceptibility of LDL to oxidation in vitro was correlated with mean IMT, it did not have a significant independent contribution to variation in mean IMT in the multivariate model.
We conclude that LDL particle size but not susceptibility of LDL to oxidation in vitro is independently associated with carotid IMT in asymptomatic FCHL family members. These results imply that small, dense LDL as an inherent feature of FCHL is an important diagnostic indicator for coronary artery disease risk in FCHL.</description><subject>Adult</subject><subject>Aged</subject><subject>Antioxidants - analysis</subject><subject>Biological and medical sciences</subject><subject>Carotid Arteries - diagnostic imaging</subject><subject>Carotid Artery Diseases - blood</subject><subject>Carotid Artery Diseases - diagnostic imaging</subject><subject>Disorders of blood lipids. Hyperlipoproteinemia</subject><subject>Female</subject><subject>Finland</subject><subject>Humans</subject><subject>Hyperlipidemia, Familial Combined - blood</subject><subject>Lipoproteins, LDL - blood</subject><subject>Lipoproteins, LDL - chemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Oxidation-Reduction</subject><subject>Particle Size</subject><subject>Predictive Value of Tests</subject><subject>Risk</subject><subject>Tunica Intima - diagnostic imaging</subject><subject>Tunica Media - diagnostic imaging</subject><subject>Ultrasonography</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kVtrFTEUhQdR7LH6FyQU9G2OucxkJr6V0qpQELQ-h1z20NSZZJydQz39m_4hcy5wQDAvIeFbK2tnVdUFo2vGJPtA2Rrzsqa7xRrFmzVXXPRrYM-qFWt5UzeS98-rFaVC1bxR6qx6hfhQ8IK1L6szxlTfS0pX1Z9LxOSCySFFYiE_AkTizJJy8CTEHCZTT-CDIfk-uJ8REImJnozpsfYQMeQtGcOc5qKAEAmGJ9gDuEEHcw42jDsmDf-V5ETS7-APEcrZ4Haac5rKhSMTTBYW3OkHMxUvMxKXJhsieHK_nWEpVsHDVBIeAMDX1YvBjAhvjvt59ePm-u7qc3379dOXq8vb2rVc5rqXysm-s2D40HDRKNN52onWe2a8EEL2rTXGKqeUMNJyxrqBCmuV72Xr-k6cV-8PvmWSXxvArKdQhh5HEyFtUHdMdq3Ygxf_gA9ps8SSTTPVdb3oBC_QxwPkloS4wKDnpfz-stWM6l3vmjL9_e6bPvWu973ra1bEb48vbGyp6yQ9Fl2Ad0fAoDPjsJjoAp44IVvVSi7-An2UviI</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>LIU, Ming-Lin</creator><creator>YLITALO, Kati</creator><creator>NUOTIO, Ilpo</creator><creator>SALONEN, Riitta</creator><creator>SALONEN, Jukka T</creator><creator>TASKINEN, Marja-Riitta</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Association between carotid intima-media thickness and low-density lipoprotein size and susceptibility of low-density lipoprotein to oxidation in asymptomatic members of familial combined hyperlipidemia families</title><author>LIU, Ming-Lin ; YLITALO, Kati ; NUOTIO, Ilpo ; SALONEN, Riitta ; SALONEN, Jukka T ; TASKINEN, Marja-Riitta</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-869c687bea2f42349a7d0735dd1ad333685baab9c993a6b2117f03bb9d865c873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antioxidants - analysis</topic><topic>Biological and medical sciences</topic><topic>Carotid Arteries - diagnostic imaging</topic><topic>Carotid Artery Diseases - blood</topic><topic>Carotid Artery Diseases - diagnostic imaging</topic><topic>Disorders of blood lipids. Hyperlipoproteinemia</topic><topic>Female</topic><topic>Finland</topic><topic>Humans</topic><topic>Hyperlipidemia, Familial Combined - blood</topic><topic>Lipoproteins, LDL - blood</topic><topic>Lipoproteins, LDL - chemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Oxidation-Reduction</topic><topic>Particle Size</topic><topic>Predictive Value of Tests</topic><topic>Risk</topic><topic>Tunica Intima - diagnostic imaging</topic><topic>Tunica Media - diagnostic imaging</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LIU, Ming-Lin</creatorcontrib><creatorcontrib>YLITALO, Kati</creatorcontrib><creatorcontrib>NUOTIO, Ilpo</creatorcontrib><creatorcontrib>SALONEN, Riitta</creatorcontrib><creatorcontrib>SALONEN, Jukka T</creatorcontrib><creatorcontrib>TASKINEN, Marja-Riitta</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIU, Ming-Lin</au><au>YLITALO, Kati</au><au>NUOTIO, Ilpo</au><au>SALONEN, Riitta</au><au>SALONEN, Jukka T</au><au>TASKINEN, Marja-Riitta</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between carotid intima-media thickness and low-density lipoprotein size and susceptibility of low-density lipoprotein to oxidation in asymptomatic members of familial combined hyperlipidemia families</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>33</volume><issue>5</issue><spage>1255</spage><epage>1260</epage><pages>1255-1260</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>In addition to low-density lipoprotein (LDL) cholesterol, small, dense LDL particles and oxidative modification of LDL have been linked to the pathogenesis of atherosclerosis. The present study was aimed at investigating the association between carotid artery intima-media thickness (IMT) and LDL particle size and susceptibility of LDL to oxidation in vitro in asymptomatic members of familial combined hyperlipidemia (FCHL) families.
LDL particle size, susceptibility of LDL to oxidation in vitro, and carotid IMT were measured in 148 asymptomatic FCHL family members.
LDL particle size and lag time for LDL oxidation were reduced in hyperlipidemic compared with normolipidemic family members. LDL particle size, serum total cholesterol, and alpha-tocopherol in LDL were independently associated with lag time for LDL oxidation in multivariate analysis. LDL particle size was associated with carotid mean IMT independently of clinical, lipid, and antioxidant variables in multivariate analysis. Although the susceptibility of LDL to oxidation in vitro was correlated with mean IMT, it did not have a significant independent contribution to variation in mean IMT in the multivariate model.
We conclude that LDL particle size but not susceptibility of LDL to oxidation in vitro is independently associated with carotid IMT in asymptomatic FCHL family members. These results imply that small, dense LDL as an inherent feature of FCHL is an important diagnostic indicator for coronary artery disease risk in FCHL.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11988600</pmid><doi>10.1161/01.str.0000014924.29238.e1</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; Journals@Ovid Complete |
| subjects | Adult Aged Antioxidants - analysis Biological and medical sciences Carotid Arteries - diagnostic imaging Carotid Artery Diseases - blood Carotid Artery Diseases - diagnostic imaging Disorders of blood lipids. Hyperlipoproteinemia Female Finland Humans Hyperlipidemia, Familial Combined - blood Lipoproteins, LDL - blood Lipoproteins, LDL - chemistry Male Medical sciences Metabolic diseases Middle Aged Multivariate Analysis Oxidation-Reduction Particle Size Predictive Value of Tests Risk Tunica Intima - diagnostic imaging Tunica Media - diagnostic imaging Ultrasonography |
| title | Association between carotid intima-media thickness and low-density lipoprotein size and susceptibility of low-density lipoprotein to oxidation in asymptomatic members of familial combined hyperlipidemia families |
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