Bone formation in carotid plaques: A clinicopathological study
Bone formation and dystrophic calcification are present in carotid endarterectomy plaques. The clinical significance of these findings is unknown. The purpose of this study was to determine whether bone formation and extensive dystrophic calcification are associated with stable plaques and protectiv...
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| Veröffentlicht in: | Stroke (1970) 2002-05, Vol.33 (5), p.1214-1219 |
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| creator | HUNT, Jennifer L FAIRMAN, Ronald CUSACK, Anita MOHLER, Emile R MITCHELL, Marc E CARPENTER, Jeffrey P GOLDEN, Michael KHALAPYAN, Tigran WOLFE, Megan NESCHIS, David MILNER, Ross SCOLL, Benjamin |
| description | Bone formation and dystrophic calcification are present in carotid endarterectomy plaques. The clinical significance of these findings is unknown. The purpose of this study was to determine whether bone formation and extensive dystrophic calcification are associated with stable plaques and protective against ischemic vascular events.
Carotid endarterectomy plaques were collected from 142 patients (94 men) with carotid stenosis. The specimens were evaluated for lamellar bone formation, dystrophic calcifications, inflammatory infiltrates, neovascularization, and histological type or grade of plaque according to a standard AHA grading system. Immunohistochemical staining was performed to identify vascular endothelial cells in neovascularization (factor VIII) and lymphocytes. Clinical data, including history of cerebrovascular and cardiovascular events, were recorded at the time of surgery.
Patients with calcification of carotid plaques had fewer symptoms of stroke and transient ischemic attack (P=0.042) than those without calcification. Stroke and transient ischemic attack occurred less frequently in patients with plaques with large calcific granules (P=0.021). Of the patients, 13% had lamellar bone formation, which directly correlated with the presence of sheetlike calcifications (P=0.0001) and inversely correlated with ulcerated lesions (P=0.048). The presence of bone also correlated with diabetes (P |
| doi_str_mv | 10.1161/01.STR.0000013741.41309.67 |
| format | Article |
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Carotid endarterectomy plaques were collected from 142 patients (94 men) with carotid stenosis. The specimens were evaluated for lamellar bone formation, dystrophic calcifications, inflammatory infiltrates, neovascularization, and histological type or grade of plaque according to a standard AHA grading system. Immunohistochemical staining was performed to identify vascular endothelial cells in neovascularization (factor VIII) and lymphocytes. Clinical data, including history of cerebrovascular and cardiovascular events, were recorded at the time of surgery.
Patients with calcification of carotid plaques had fewer symptoms of stroke and transient ischemic attack (P=0.042) than those without calcification. Stroke and transient ischemic attack occurred less frequently in patients with plaques with large calcific granules (P=0.021). Of the patients, 13% had lamellar bone formation, which directly correlated with the presence of sheetlike calcifications (P=0.0001) and inversely correlated with ulcerated lesions (P=0.048). The presence of bone also correlated with diabetes (P<0.01) and coronary artery disease (P<0.01). Of the 20 patients with bone, 6 had a history of stoke and transient ischemic attack (P=0.5).
The results indicate that bone formation tends to occur in heavily calcified carotid lesions devoid of ulceration and hemorrhage. Patients with extensive calcification of the carotid plaques are less likely to have symptomatic disease.</description><identifier>ISSN: 0039-2499</identifier><identifier>EISSN: 1524-4628</identifier><identifier>DOI: 10.1161/01.STR.0000013741.41309.67</identifier><identifier>PMID: 11988593</identifier><identifier>CODEN: SJCCA7</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Arteriosclerosis - complications ; Arteriosclerosis - pathology ; Biological and medical sciences ; Calcinosis - complications ; Calcinosis - pathology ; Carotid Stenosis - complications ; Carotid Stenosis - pathology ; Carotid Stenosis - surgery ; Demography ; Endarterectomy, Carotid ; Female ; Humans ; Immunohistochemistry ; Ischemic Attack, Transient - complications ; Male ; Medical sciences ; Middle Aged ; Neurology ; Osteogenesis ; Prospective Studies ; Risk Factors ; Stroke - complications ; Vascular diseases and vascular malformations of the nervous system</subject><ispartof>Stroke (1970), 2002-05, Vol.33 (5), p.1214-1219</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright American Heart Association, Inc. May 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-83f14b9d8023d0020516ad8d1eaa2ee8152a2a45cc8f69bc178a91978a0634313</citedby><cites>FETCH-LOGICAL-c408t-83f14b9d8023d0020516ad8d1eaa2ee8152a2a45cc8f69bc178a91978a0634313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,3689,27931,27932</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13659555$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11988593$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>HUNT, Jennifer L</creatorcontrib><creatorcontrib>FAIRMAN, Ronald</creatorcontrib><creatorcontrib>CUSACK, Anita</creatorcontrib><creatorcontrib>MOHLER, Emile R</creatorcontrib><creatorcontrib>MITCHELL, Marc E</creatorcontrib><creatorcontrib>CARPENTER, Jeffrey P</creatorcontrib><creatorcontrib>GOLDEN, Michael</creatorcontrib><creatorcontrib>KHALAPYAN, Tigran</creatorcontrib><creatorcontrib>WOLFE, Megan</creatorcontrib><creatorcontrib>NESCHIS, David</creatorcontrib><creatorcontrib>MILNER, Ross</creatorcontrib><creatorcontrib>SCOLL, Benjamin</creatorcontrib><title>Bone formation in carotid plaques: A clinicopathological study</title><title>Stroke (1970)</title><addtitle>Stroke</addtitle><description>Bone formation and dystrophic calcification are present in carotid endarterectomy plaques. The clinical significance of these findings is unknown. The purpose of this study was to determine whether bone formation and extensive dystrophic calcification are associated with stable plaques and protective against ischemic vascular events.
Carotid endarterectomy plaques were collected from 142 patients (94 men) with carotid stenosis. The specimens were evaluated for lamellar bone formation, dystrophic calcifications, inflammatory infiltrates, neovascularization, and histological type or grade of plaque according to a standard AHA grading system. Immunohistochemical staining was performed to identify vascular endothelial cells in neovascularization (factor VIII) and lymphocytes. Clinical data, including history of cerebrovascular and cardiovascular events, were recorded at the time of surgery.
Patients with calcification of carotid plaques had fewer symptoms of stroke and transient ischemic attack (P=0.042) than those without calcification. Stroke and transient ischemic attack occurred less frequently in patients with plaques with large calcific granules (P=0.021). Of the patients, 13% had lamellar bone formation, which directly correlated with the presence of sheetlike calcifications (P=0.0001) and inversely correlated with ulcerated lesions (P=0.048). The presence of bone also correlated with diabetes (P<0.01) and coronary artery disease (P<0.01). Of the 20 patients with bone, 6 had a history of stoke and transient ischemic attack (P=0.5).
The results indicate that bone formation tends to occur in heavily calcified carotid lesions devoid of ulceration and hemorrhage. Patients with extensive calcification of the carotid plaques are less likely to have symptomatic disease.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Arteriosclerosis - complications</subject><subject>Arteriosclerosis - pathology</subject><subject>Biological and medical sciences</subject><subject>Calcinosis - complications</subject><subject>Calcinosis - pathology</subject><subject>Carotid Stenosis - complications</subject><subject>Carotid Stenosis - pathology</subject><subject>Carotid Stenosis - surgery</subject><subject>Demography</subject><subject>Endarterectomy, Carotid</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Ischemic Attack, Transient - complications</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neurology</subject><subject>Osteogenesis</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Stroke - complications</subject><subject>Vascular diseases and vascular malformations of the nervous system</subject><issn>0039-2499</issn><issn>1524-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkMtKAzEUQIMotj5-QYaC7mbMnTwm6UKoxRcUBB_rkGYymjKd1GRm4d-baqFgFsnm3JvDQWgCuADgcI2heH17KfD2AKkoFBQIlgWvDtAYWElzyktxiMYYE5mXVMoROolxlfCSCHaMRgBSCCbJGN3c-s5mjQ9r3TvfZa7LjA6-d3W2afXXYOM0m2WmdZ0zfqP7T9_6D2d0m8V-qL_P0FGj22jPd-8per-_e5s_5ovnh6f5bJEbikWfC9IAXcpaJIE6WWAGXNeiBqt1aa1I0rrUlBkjGi6XBiqhJch0Y04oAXKKrv72boLfSvVq7aKxbas764eoKuAVI4wlcPIPXPkhdMlNpX0yrYMyQdM_yAQfY7CN2gS31uFbAVbbxAqDSonVPrH6Tax4lYYvdj8My7Wt96O7pgm43AE6plBN0J1xcc8RziRLqj-6i4Ld</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>HUNT, Jennifer L</creator><creator>FAIRMAN, Ronald</creator><creator>CUSACK, Anita</creator><creator>MOHLER, Emile R</creator><creator>MITCHELL, Marc E</creator><creator>CARPENTER, Jeffrey P</creator><creator>GOLDEN, Michael</creator><creator>KHALAPYAN, Tigran</creator><creator>WOLFE, Megan</creator><creator>NESCHIS, David</creator><creator>MILNER, Ross</creator><creator>SCOLL, Benjamin</creator><general>Lippincott Williams & Wilkins</general><general>American Heart Association, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Bone formation in carotid plaques: A clinicopathological study</title><author>HUNT, Jennifer L ; FAIRMAN, Ronald ; CUSACK, Anita ; MOHLER, Emile R ; MITCHELL, Marc E ; CARPENTER, Jeffrey P ; GOLDEN, Michael ; KHALAPYAN, Tigran ; WOLFE, Megan ; NESCHIS, David ; MILNER, Ross ; SCOLL, Benjamin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-83f14b9d8023d0020516ad8d1eaa2ee8152a2a45cc8f69bc178a91978a0634313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Arteriosclerosis - complications</topic><topic>Arteriosclerosis - pathology</topic><topic>Biological and medical sciences</topic><topic>Calcinosis - complications</topic><topic>Calcinosis - pathology</topic><topic>Carotid Stenosis - complications</topic><topic>Carotid Stenosis - pathology</topic><topic>Carotid Stenosis - surgery</topic><topic>Demography</topic><topic>Endarterectomy, Carotid</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Ischemic Attack, Transient - complications</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neurology</topic><topic>Osteogenesis</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Stroke - complications</topic><topic>Vascular diseases and vascular malformations of the nervous system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>HUNT, Jennifer L</creatorcontrib><creatorcontrib>FAIRMAN, Ronald</creatorcontrib><creatorcontrib>CUSACK, Anita</creatorcontrib><creatorcontrib>MOHLER, Emile R</creatorcontrib><creatorcontrib>MITCHELL, Marc E</creatorcontrib><creatorcontrib>CARPENTER, Jeffrey P</creatorcontrib><creatorcontrib>GOLDEN, Michael</creatorcontrib><creatorcontrib>KHALAPYAN, Tigran</creatorcontrib><creatorcontrib>WOLFE, Megan</creatorcontrib><creatorcontrib>NESCHIS, David</creatorcontrib><creatorcontrib>MILNER, Ross</creatorcontrib><creatorcontrib>SCOLL, Benjamin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Stroke (1970)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>HUNT, Jennifer L</au><au>FAIRMAN, Ronald</au><au>CUSACK, Anita</au><au>MOHLER, Emile R</au><au>MITCHELL, Marc E</au><au>CARPENTER, Jeffrey P</au><au>GOLDEN, Michael</au><au>KHALAPYAN, Tigran</au><au>WOLFE, Megan</au><au>NESCHIS, David</au><au>MILNER, Ross</au><au>SCOLL, Benjamin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone formation in carotid plaques: A clinicopathological study</atitle><jtitle>Stroke (1970)</jtitle><addtitle>Stroke</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>33</volume><issue>5</issue><spage>1214</spage><epage>1219</epage><pages>1214-1219</pages><issn>0039-2499</issn><eissn>1524-4628</eissn><coden>SJCCA7</coden><abstract>Bone formation and dystrophic calcification are present in carotid endarterectomy plaques. The clinical significance of these findings is unknown. The purpose of this study was to determine whether bone formation and extensive dystrophic calcification are associated with stable plaques and protective against ischemic vascular events.
Carotid endarterectomy plaques were collected from 142 patients (94 men) with carotid stenosis. The specimens were evaluated for lamellar bone formation, dystrophic calcifications, inflammatory infiltrates, neovascularization, and histological type or grade of plaque according to a standard AHA grading system. Immunohistochemical staining was performed to identify vascular endothelial cells in neovascularization (factor VIII) and lymphocytes. Clinical data, including history of cerebrovascular and cardiovascular events, were recorded at the time of surgery.
Patients with calcification of carotid plaques had fewer symptoms of stroke and transient ischemic attack (P=0.042) than those without calcification. Stroke and transient ischemic attack occurred less frequently in patients with plaques with large calcific granules (P=0.021). Of the patients, 13% had lamellar bone formation, which directly correlated with the presence of sheetlike calcifications (P=0.0001) and inversely correlated with ulcerated lesions (P=0.048). The presence of bone also correlated with diabetes (P<0.01) and coronary artery disease (P<0.01). Of the 20 patients with bone, 6 had a history of stoke and transient ischemic attack (P=0.5).
The results indicate that bone formation tends to occur in heavily calcified carotid lesions devoid of ulceration and hemorrhage. Patients with extensive calcification of the carotid plaques are less likely to have symptomatic disease.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>11988593</pmid><doi>10.1161/01.STR.0000013741.41309.67</doi><tpages>6</tpages></addata></record> |
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| ispartof | Stroke (1970), 2002-05, Vol.33 (5), p.1214-1219 |
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| source | MEDLINE; American Heart Association Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; Alma/SFX Local Collection |
| subjects | Adult Aged Aged, 80 and over Arteriosclerosis - complications Arteriosclerosis - pathology Biological and medical sciences Calcinosis - complications Calcinosis - pathology Carotid Stenosis - complications Carotid Stenosis - pathology Carotid Stenosis - surgery Demography Endarterectomy, Carotid Female Humans Immunohistochemistry Ischemic Attack, Transient - complications Male Medical sciences Middle Aged Neurology Osteogenesis Prospective Studies Risk Factors Stroke - complications Vascular diseases and vascular malformations of the nervous system |
| title | Bone formation in carotid plaques: A clinicopathological study |
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