Acute promyelocytic leukemia: where does it stem from?

A fundamental issue in cancer biology is the identification of the target cell in which the causative molecular lesion arises. Acute myeloid leukemia (AML) is thought to reflect the transformation of a primitive stem cell compartment. The resultant 'cancer stem cells' comprise only a minor...

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Veröffentlicht in:	Leukemia 2004-03, Vol.18 (3), p.375-384
Hauptverfasser:	GRIMWADE, D, ENVER, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acute myeloid leukemia Acute promyeloid leukemia Arsenic Biological and medical sciences Cancer Cell Differentiation Cell Lineage Cell self-renewal Cloning DNA methylation Hematologic and hematopoietic diseases Hematology Hematopoietic Stem Cells - pathology Humans Leukemia Leukemia, Myeloid - pathology Leukemia, Promyelocytic, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Ligands Medical sciences Medicine Morphology Progenitor cells Promyeloid leukemia Stem cells Tumors
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