Gentamicin and Tetracyclines for the Treatment of Human Plague: Review of 75 Cases in New Mexico, 1985–1999
Streptomycin, an antimicrobial with limited availability, is the treatment of choice for plague, a fulminating and potentially epidemic disease that poses a bioterrorism concern. We evaluated the efficacy of gentamicin and tetracyclines for treating human plague. A medical record review was conducte...
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| Veröffentlicht in: | Clinical infectious diseases 2004-03, Vol.38 (5), p.663-669 |
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| container_title | Clinical infectious diseases |
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| creator | Boulanger, L. Lucy Ettestad, Paul Fogarty, John D. Dennis, David T. Romig, Donald Mertz, Gregory |
| description | Streptomycin, an antimicrobial with limited availability, is the treatment of choice for plague, a fulminating and potentially epidemic disease that poses a bioterrorism concern. We evaluated the efficacy of gentamicin and tetracyclines for treating human plague. A medical record review was conducted on all 75 patients with plague who were reported in New Mexico during 1985-1999. Fifty patients were included in an analysis that compared streptomycin-treated patients (n = 14) with those treated with gentamicin and/or a tetracycline (n = 36). The mean numbers of fever days, hospital days, and complications and the number of deaths did not differ between patients treated with streptomycin and those treated with gentamicin. One patient who received tetracycline alone experienced a serious complication. Gentamicin alone or in combination with a tetracycline was as efficacious as streptomycin for treating human plague. The efficacy of a tetracycline alone could not be determined from the study. |
| doi_str_mv | 10.1086/381545 |
| format | Article |
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Antiparasitic agents</subject><subject>Antimicrobials</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Bioterrorism</subject><subject>Diseases</subject><subject>Drug Therapy, Combination - therapeutic use</subject><subject>Epidemics</subject><subject>Female</subject><subject>Fever</subject><subject>Gentamicins - therapeutic use</subject><subject>Hospitalization</subject><subject>Human bacterial diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Length of Stay</subject><subject>Major Articles</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. 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| fulltext | fulltext |
| identifier | ISSN: 1058-4838 |
| ispartof | Clinical infectious diseases, 2004-03, Vol.38 (5), p.663-669 |
| issn | 1058-4838 1537-6591 |
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| source | MEDLINE; Jstor Complete Legacy; Oxford University Press Journals All Titles (1996-Current); EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobials Bacterial diseases Biological and medical sciences Bioterrorism Diseases Drug Therapy, Combination - therapeutic use Epidemics Female Fever Gentamicins - therapeutic use Hospitalization Human bacterial diseases Humans Infectious diseases Length of Stay Major Articles Male Medical sciences Pharmacology. Drug treatments Plague Plague - complications Plague - drug therapy Plague - mortality Retrospective Studies Septicemic plague Streptomycin - therapeutic use Sulfonamides Tetracyclines - therapeutic use Tropical bacterial diseases Yersinia pestis - drug effects |
| title | Gentamicin and Tetracyclines for the Treatment of Human Plague: Review of 75 Cases in New Mexico, 1985–1999 |
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