The Wegener’s granulomatosis quantitative trait locus on chromosome 6p21.3 as characterised by tagSNP genotyping

Background:A genomic region on chromosome 6p21.3, including HLA-DPB1, has been linked to Wegener’s granulomatosis (WG). The basis of this association is difficult to evaluate because of the complex haplotype block architecture of this region.Objective:To identify the causative molecular genetic vari...

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Veröffentlicht in:	Annals of the rheumatic diseases 2008-07, Vol.67 (7), p.972-979
Hauptverfasser:	Heckmann, M, Holle, J U, Arning, L, Knaup, S, Hellmich, B, Nothnagel, M, Jagiello, P, Gross, W L, Epplen, J T, Wieczorek, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Antineutrophil Cytoplasmic - blood Biological and medical sciences Chromosomes, Human, Pair 6 - genetics Diseases of the osteoarticular system DNA-Binding Proteins - genetics Gene Frequency Genes Genetic Predisposition to Disease Genotype Granulomatosis with Polyangiitis - genetics Granulomatosis with Polyangiitis - immunology Haplotypes Hearing loss Histocompatibility Testing - methods HLA-DP Antigens - genetics HLA-DP beta-Chains Humans Medical sciences Pathogenesis Polycomb Repressive Complex 1 Polymorphism, Single Nucleotide Proteins Quantitative Trait Loci Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis Studies
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