Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis
Objectives:Osteoarthritis (OA) structural changes take place over decades in humans. MRI can provide precise and reliable information on the joint structure and changes over time. In this study, we investigated the reliability of quantitative MRI in assessing knee OA structural changes in the experi...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2008-07, Vol.67 (7), p.926-932 |
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| creator | Boileau, C Martel-Pelletier, J Abram, F Raynauld, J-P Troncy, É D’Anjou, M-A Moreau, M Pelletier, J-P |
| description | Objectives:Osteoarthritis (OA) structural changes take place over decades in humans. MRI can provide precise and reliable information on the joint structure and changes over time. In this study, we investigated the reliability of quantitative MRI in assessing knee OA structural changes in the experimental anterior cruciate ligament (ACL) dog model of OA.Methods:OA was surgically induced by transection of the ACL of the right knee in five dogs. High resolution three dimensional MRI using a 1.5 T magnet was performed at baseline, 4, 8 and 26 weeks post surgery. Cartilage volume/thickness, cartilage defects, trochlear osteophyte formation and subchondral bone lesion (hypersignal) were assessed on MRI images. Animals were killed 26 weeks post surgery and macroscopic evaluation was performed.Results:There was a progressive and significant increase over time in the loss of knee cartilage volume, the cartilage defect and subchondral bone hypersignal. The trochlear osteophyte size also progressed over time. The greatest cartilage loss at 26 weeks was found on the tibial plateaus and in the medial compartment. There was a highly significant correlation between total knee cartilage volume loss or defect and subchondral bone hypersignal, and also a good correlation between the macroscopic and the MRI findings.Conclusion:This study demonstrated that MRI is a useful technology to provide a non-invasive and reliable assessment of the joint structural changes during the development of OA in the ACL dog model. The combination of this OA model with MRI evaluation provides a promising tool for the evaluation of new disease-modifying osteoarthritis drugs (DMOADs). |
| doi_str_mv | 10.1136/ard.2007.077297 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71673725</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4008463521</sourcerecordid><originalsourceid>FETCH-LOGICAL-b482t-6f9ef5db43ee29365b97e6a297ebbd5912b3b077fb5b8f1e3ca8acb83384f5303</originalsourceid><addsrcrecordid>eNqFkUtvEzEUhUcIRENhzQ5ZQrBAmtSPGduzRBHhVWBTWHRj2c6didMZO9geqf0H_GwcJSoSm64s29-5j3Oq6iXBS0IYv9Bxs6QYiyUWgnbiUbUgDZc1xRw_rhYYY1Y3HRdn1bOUduWKJZFPqzMiOk4p44vqzzc9eMjOoggpeO0tIDfpwfkBWe2RtnaOOsN4h3RKkBLKW0Bj8EOdIU5oH8NQlMkFj0KPbjwASjnONhfZiOxW-wESch7B7R6im8Dn8r4JAwopQ9Axb6PLLj2vnvR6TPDidJ5XP9cfrlaf6ssfHz-v3l_WppE017zvoG83pmEAtGO8NZ0ArsvuYMym7Qg1zBQzetMa2RNgVkttjWRMNn3LMDuv3h7rlsl_z5CymlyyMI7aQ5iTEoQLJmj7IEixkJJKXsDX_4G7MEdfllBECCHbVmBaqIsjZWNIKUKv9sUNHe8UweqQpSpZqkOW6phlUbw61Z3NBJt__Cm8Arw5ATpZPfaxpOfSPUdxgwmTh9b1kXPF8dv7fx1v1GHXVn3_tVL8av3lmn5dq-vCvzvyZto9OOVfOXjGYA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1777855702</pqid></control><display><type>article</type><title>Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis</title><source>MEDLINE</source><source>BMJ Journals - NESLi2</source><creator>Boileau, C ; Martel-Pelletier, J ; Abram, F ; Raynauld, J-P ; Troncy, É ; D’Anjou, M-A ; Moreau, M ; Pelletier, J-P</creator><creatorcontrib>Boileau, C ; Martel-Pelletier, J ; Abram, F ; Raynauld, J-P ; Troncy, É ; D’Anjou, M-A ; Moreau, M ; Pelletier, J-P</creatorcontrib><description>Objectives:Osteoarthritis (OA) structural changes take place over decades in humans. MRI can provide precise and reliable information on the joint structure and changes over time. In this study, we investigated the reliability of quantitative MRI in assessing knee OA structural changes in the experimental anterior cruciate ligament (ACL) dog model of OA.Methods:OA was surgically induced by transection of the ACL of the right knee in five dogs. High resolution three dimensional MRI using a 1.5 T magnet was performed at baseline, 4, 8 and 26 weeks post surgery. Cartilage volume/thickness, cartilage defects, trochlear osteophyte formation and subchondral bone lesion (hypersignal) were assessed on MRI images. Animals were killed 26 weeks post surgery and macroscopic evaluation was performed.Results:There was a progressive and significant increase over time in the loss of knee cartilage volume, the cartilage defect and subchondral bone hypersignal. The trochlear osteophyte size also progressed over time. The greatest cartilage loss at 26 weeks was found on the tibial plateaus and in the medial compartment. There was a highly significant correlation between total knee cartilage volume loss or defect and subchondral bone hypersignal, and also a good correlation between the macroscopic and the MRI findings.Conclusion:This study demonstrated that MRI is a useful technology to provide a non-invasive and reliable assessment of the joint structural changes during the development of OA in the ACL dog model. The combination of this OA model with MRI evaluation provides a promising tool for the evaluation of new disease-modifying osteoarthritis drugs (DMOADs).</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.2007.077297</identifier><identifier>PMID: 17962236</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Animals ; Arthritis ; Arthritis, Experimental - pathology ; Biological and medical sciences ; Bone marrow ; Cartilage, Articular - pathology ; Disease Models, Animal ; Disease Progression ; Diseases of the osteoarticular system ; Dogs ; Knee ; Magnetic Resonance Imaging - methods ; Medical sciences ; Miscellaneous. Osteoarticular involvement in other diseases ; Morphology ; Osteoarthritis ; Osteoarthritis, Knee - pathology ; Osteophyte - pathology ; Severity of Illness Index ; Studies ; Surgery</subject><ispartof>Annals of the rheumatic diseases, 2008-07, Vol.67 (7), p.926-932</ispartof><rights>2008 BMJ Publishing Group and European League Against Rheumatism</rights><rights>2008 INIST-CNRS</rights><rights>Copyright: 2008 2008 BMJ Publishing Group and European League Against Rheumatism</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b482t-6f9ef5db43ee29365b97e6a297ebbd5912b3b077fb5b8f1e3ca8acb83384f5303</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/67/7/926.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/67/7/926.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,315,781,785,3197,23576,27929,27930,77605,77636</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20401382$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17962236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boileau, C</creatorcontrib><creatorcontrib>Martel-Pelletier, J</creatorcontrib><creatorcontrib>Abram, F</creatorcontrib><creatorcontrib>Raynauld, J-P</creatorcontrib><creatorcontrib>Troncy, É</creatorcontrib><creatorcontrib>D’Anjou, M-A</creatorcontrib><creatorcontrib>Moreau, M</creatorcontrib><creatorcontrib>Pelletier, J-P</creatorcontrib><title>Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis</title><title>Annals of the rheumatic diseases</title><addtitle>Ann Rheum Dis</addtitle><description>Objectives:Osteoarthritis (OA) structural changes take place over decades in humans. MRI can provide precise and reliable information on the joint structure and changes over time. In this study, we investigated the reliability of quantitative MRI in assessing knee OA structural changes in the experimental anterior cruciate ligament (ACL) dog model of OA.Methods:OA was surgically induced by transection of the ACL of the right knee in five dogs. High resolution three dimensional MRI using a 1.5 T magnet was performed at baseline, 4, 8 and 26 weeks post surgery. Cartilage volume/thickness, cartilage defects, trochlear osteophyte formation and subchondral bone lesion (hypersignal) were assessed on MRI images. Animals were killed 26 weeks post surgery and macroscopic evaluation was performed.Results:There was a progressive and significant increase over time in the loss of knee cartilage volume, the cartilage defect and subchondral bone hypersignal. The trochlear osteophyte size also progressed over time. The greatest cartilage loss at 26 weeks was found on the tibial plateaus and in the medial compartment. There was a highly significant correlation between total knee cartilage volume loss or defect and subchondral bone hypersignal, and also a good correlation between the macroscopic and the MRI findings.Conclusion:This study demonstrated that MRI is a useful technology to provide a non-invasive and reliable assessment of the joint structural changes during the development of OA in the ACL dog model. The combination of this OA model with MRI evaluation provides a promising tool for the evaluation of new disease-modifying osteoarthritis drugs (DMOADs).</description><subject>Animals</subject><subject>Arthritis</subject><subject>Arthritis, Experimental - pathology</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Cartilage, Articular - pathology</subject><subject>Disease Models, Animal</subject><subject>Disease Progression</subject><subject>Diseases of the osteoarticular system</subject><subject>Dogs</subject><subject>Knee</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Medical sciences</subject><subject>Miscellaneous. Osteoarticular involvement in other diseases</subject><subject>Morphology</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis, Knee - pathology</subject><subject>Osteophyte - pathology</subject><subject>Severity of Illness Index</subject><subject>Studies</subject><subject>Surgery</subject><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkUtvEzEUhUcIRENhzQ5ZQrBAmtSPGduzRBHhVWBTWHRj2c6didMZO9geqf0H_GwcJSoSm64s29-5j3Oq6iXBS0IYv9Bxs6QYiyUWgnbiUbUgDZc1xRw_rhYYY1Y3HRdn1bOUduWKJZFPqzMiOk4p44vqzzc9eMjOoggpeO0tIDfpwfkBWe2RtnaOOsN4h3RKkBLKW0Bj8EOdIU5oH8NQlMkFj0KPbjwASjnONhfZiOxW-wESch7B7R6im8Dn8r4JAwopQ9Axb6PLLj2vnvR6TPDidJ5XP9cfrlaf6ssfHz-v3l_WppE017zvoG83pmEAtGO8NZ0ArsvuYMym7Qg1zBQzetMa2RNgVkttjWRMNn3LMDuv3h7rlsl_z5CymlyyMI7aQ5iTEoQLJmj7IEixkJJKXsDX_4G7MEdfllBECCHbVmBaqIsjZWNIKUKv9sUNHe8UweqQpSpZqkOW6phlUbw61Z3NBJt__Cm8Arw5ATpZPfaxpOfSPUdxgwmTh9b1kXPF8dv7fx1v1GHXVn3_tVL8av3lmn5dq-vCvzvyZto9OOVfOXjGYA</recordid><startdate>20080701</startdate><enddate>20080701</enddate><creator>Boileau, C</creator><creator>Martel-Pelletier, J</creator><creator>Abram, F</creator><creator>Raynauld, J-P</creator><creator>Troncy, É</creator><creator>D’Anjou, M-A</creator><creator>Moreau, M</creator><creator>Pelletier, J-P</creator><general>BMJ Publishing Group Ltd and European League Against Rheumatism</general><general>BMJ</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7QP</scope><scope>7X8</scope></search><sort><creationdate>20080701</creationdate><title>Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis</title><author>Boileau, C ; Martel-Pelletier, J ; Abram, F ; Raynauld, J-P ; Troncy, É ; D’Anjou, M-A ; Moreau, M ; Pelletier, J-P</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b482t-6f9ef5db43ee29365b97e6a297ebbd5912b3b077fb5b8f1e3ca8acb83384f5303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Animals</topic><topic>Arthritis</topic><topic>Arthritis, Experimental - pathology</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Cartilage, Articular - pathology</topic><topic>Disease Models, Animal</topic><topic>Disease Progression</topic><topic>Diseases of the osteoarticular system</topic><topic>Dogs</topic><topic>Knee</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Medical sciences</topic><topic>Miscellaneous. Osteoarticular involvement in other diseases</topic><topic>Morphology</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis, Knee - pathology</topic><topic>Osteophyte - pathology</topic><topic>Severity of Illness Index</topic><topic>Studies</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boileau, C</creatorcontrib><creatorcontrib>Martel-Pelletier, J</creatorcontrib><creatorcontrib>Abram, F</creatorcontrib><creatorcontrib>Raynauld, J-P</creatorcontrib><creatorcontrib>Troncy, É</creatorcontrib><creatorcontrib>D’Anjou, M-A</creatorcontrib><creatorcontrib>Moreau, M</creatorcontrib><creatorcontrib>Pelletier, J-P</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boileau, C</au><au>Martel-Pelletier, J</au><au>Abram, F</au><au>Raynauld, J-P</au><au>Troncy, É</au><au>D’Anjou, M-A</au><au>Moreau, M</au><au>Pelletier, J-P</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis</atitle><jtitle>Annals of the rheumatic diseases</jtitle><addtitle>Ann Rheum Dis</addtitle><date>2008-07-01</date><risdate>2008</risdate><volume>67</volume><issue>7</issue><spage>926</spage><epage>932</epage><pages>926-932</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Objectives:Osteoarthritis (OA) structural changes take place over decades in humans. MRI can provide precise and reliable information on the joint structure and changes over time. In this study, we investigated the reliability of quantitative MRI in assessing knee OA structural changes in the experimental anterior cruciate ligament (ACL) dog model of OA.Methods:OA was surgically induced by transection of the ACL of the right knee in five dogs. High resolution three dimensional MRI using a 1.5 T magnet was performed at baseline, 4, 8 and 26 weeks post surgery. Cartilage volume/thickness, cartilage defects, trochlear osteophyte formation and subchondral bone lesion (hypersignal) were assessed on MRI images. Animals were killed 26 weeks post surgery and macroscopic evaluation was performed.Results:There was a progressive and significant increase over time in the loss of knee cartilage volume, the cartilage defect and subchondral bone hypersignal. The trochlear osteophyte size also progressed over time. The greatest cartilage loss at 26 weeks was found on the tibial plateaus and in the medial compartment. There was a highly significant correlation between total knee cartilage volume loss or defect and subchondral bone hypersignal, and also a good correlation between the macroscopic and the MRI findings.Conclusion:This study demonstrated that MRI is a useful technology to provide a non-invasive and reliable assessment of the joint structural changes during the development of OA in the ACL dog model. The combination of this OA model with MRI evaluation provides a promising tool for the evaluation of new disease-modifying osteoarthritis drugs (DMOADs).</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and European League Against Rheumatism</pub><pmid>17962236</pmid><doi>10.1136/ard.2007.077297</doi><tpages>7</tpages></addata></record> |
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| subjects | Animals Arthritis Arthritis, Experimental - pathology Biological and medical sciences Bone marrow Cartilage, Articular - pathology Disease Models, Animal Disease Progression Diseases of the osteoarticular system Dogs Knee Magnetic Resonance Imaging - methods Medical sciences Miscellaneous. Osteoarticular involvement in other diseases Morphology Osteoarthritis Osteoarthritis, Knee - pathology Osteophyte - pathology Severity of Illness Index Studies Surgery |
| title | Magnetic resonance imaging can accurately assess the long-term progression of knee structural changes in experimental dog osteoarthritis |
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