Development of a universal influenza A vaccine based on the M2e peptide fused to the papaya mosaic virus (PapMV) vaccine platform

Abstract With the emergence of highly virulent influenza viruses and the consequent risk of pandemics, new approaches to designing universal influenza vaccines are urgently needed. In this report, we demonstrate the potential of using a papaya mosaic virus (PapMV) platform carrying the universal M2e...

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Veröffentlicht in:	Vaccine 2008-06, Vol.26 (27), p.3395-3403
Hauptverfasser:	Denis, Jérôme, Acosta-Ramirez, Elizabeth, Zhao, Yinghi, Hamelin, Marie-Eve, Koukavica, Irena, Baz, Mariana, Abed, Yacine, Savard, Christian, Pare, Christine, Lopez Macias, Constantino, Boivin, Guy, Leclerc, Denis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Immunologic - administration & dosage Allergy and Immunology Alum Compounds - administration & dosage Alum Compounds - pharmacology Animals Antibodies, Viral Applied microbiology Biological and medical sciences Cloning E coli Experiments Fundamental and applied biological sciences. Psychology Genetic Vectors Human papillomavirus Immune system Immunogenicity Infections Influenza A M2e peptide Influenza Vaccines - genetics Influenza Vaccines - immunology Medical research Mice Mice, Inbred BALB C Microbiology Miscellaneous Orthomyxoviridae Infections - prevention & control Pandemics Papaya mosaic virus Papaya mosaic virus (PapMV) Peptides Potexvirus - genetics Proteins Survival Analysis Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Viral Matrix Proteins - genetics Viral Matrix Proteins - immunology Virology Virosomes - administration & dosage Virosomes - pharmacology Virus-like particles (VLPs)
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