The effect of anti-allergic mattress encasings on house dust mite-induced early- and late-airway reactions in asthmatic patients. A double-blind, placebo-controlled study
Background Anti‐allergic mattress encasing may provide clinical benefit in asthmatic patients. However, the effect of mattress encasings on allergen‐specific parameters, such as bronchial reactions to house dust mite (HDM) challenge, is not clear. Objective To investigate the effect of anti‐allergic...
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Veröffentlicht in: | Clinical and experimental allergy 2002-01, Vol.32 (1), p.117-125 |
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creator | Rijssenbeek-Nouwens, L. H. M. Oosting, A. J. De Monchy, J. G. R. Bregman, I. Postma, D. S. De Bruin-Weller, M. S. |
description | Background Anti‐allergic mattress encasing may provide clinical benefit in asthmatic patients. However, the effect of mattress encasings on allergen‐specific parameters, such as bronchial reactions to house dust mite (HDM) challenge, is not clear.
Objective To investigate the effect of anti‐allergic mattress encasings on allergen sensitivity in patients with moderate to severe asthma.
Methods Twenty‐seven patients with asthma and HDM allergy were studied in a double‐blind, placebo‐controlled study. Concentrations of Dermatophagoides pteronyssinus (Der p 1) were measured in mattress dust before and after 1 year of treatment; bronchial histamine challenge, bronchial challenge with HDM and intradermal skin challenges with HDM were performed. The number of eosinophils in peripheral blood was assessed.
Results In the active group, but not in the placebo group, there was a significant reduction in Der p 1 concentration in the dust collected from the mattresses after 1 year of treatment compared to before. There was a significant difference between the groups with respect to HDM‐induced early‐reaction (ER) in the airways and the number of blood eosinophils, which reflected an increase in ER and eosinophils in the placebo group without significant change in the active group. No significant improvement in PC20 histamine, late‐reaction (LR) and skin tests was found in either groups.
Conclusion Our data suggest that encasings protect against a further increase in allergen sensitivity in asthmatic patients, so their use should be recommended. |
doi_str_mv | 10.1046/j.0022-0477.2001.01256.x |
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Objective To investigate the effect of anti‐allergic mattress encasings on allergen sensitivity in patients with moderate to severe asthma.
Methods Twenty‐seven patients with asthma and HDM allergy were studied in a double‐blind, placebo‐controlled study. Concentrations of Dermatophagoides pteronyssinus (Der p 1) were measured in mattress dust before and after 1 year of treatment; bronchial histamine challenge, bronchial challenge with HDM and intradermal skin challenges with HDM were performed. The number of eosinophils in peripheral blood was assessed.
Results In the active group, but not in the placebo group, there was a significant reduction in Der p 1 concentration in the dust collected from the mattresses after 1 year of treatment compared to before. There was a significant difference between the groups with respect to HDM‐induced early‐reaction (ER) in the airways and the number of blood eosinophils, which reflected an increase in ER and eosinophils in the placebo group without significant change in the active group. No significant improvement in PC20 histamine, late‐reaction (LR) and skin tests was found in either groups.
Conclusion Our data suggest that encasings protect against a further increase in allergen sensitivity in asthmatic patients, so their use should be recommended.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1046/j.0022-0477.2001.01256.x</identifier><identifier>PMID: 12002728</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science, Ltd</publisher><subject>Adolescent ; Adult ; allergic asthma ; Allergic diseases ; Animals ; Antigens, Dermatophagoides ; Asthma - immunology ; Asthma - physiopathology ; Bedding and Linens ; Biological and medical sciences ; bronchial allergen challenge ; Child ; Double-Blind Method ; Dust ; Eosinophils - pathology ; Female ; Forced Expiratory Volume ; Glycoproteins - analysis ; Histamine Release ; house dust mite ; Humans ; Hypersensitivity - immunology ; Hypersensitivity - prevention & control ; Immunoglobulin E - analysis ; Immunopathology ; Male ; mattress encasings ; Medical sciences ; Middle Aged ; Mites - immunology ; Osmolar Concentration ; Respiratory and ent allergic diseases ; Skin - immunology ; Time Factors</subject><ispartof>Clinical and experimental allergy, 2002-01, Vol.32 (1), p.117-125</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Jan 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5576-b5d96e756365b64d7845d7ebb7e91d713e8af4c07dce8e1a4aa55a615503663b3</citedby><cites>FETCH-LOGICAL-c5576-b5d96e756365b64d7845d7ebb7e91d713e8af4c07dce8e1a4aa55a615503663b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.0022-0477.2001.01256.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.0022-0477.2001.01256.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,4024,27923,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13778038$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12002728$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rijssenbeek-Nouwens, L. H. M.</creatorcontrib><creatorcontrib>Oosting, A. J.</creatorcontrib><creatorcontrib>De Monchy, J. G. R.</creatorcontrib><creatorcontrib>Bregman, I.</creatorcontrib><creatorcontrib>Postma, D. S.</creatorcontrib><creatorcontrib>De Bruin-Weller, M. S.</creatorcontrib><title>The effect of anti-allergic mattress encasings on house dust mite-induced early- and late-airway reactions in asthmatic patients. A double-blind, placebo-controlled study</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Background Anti‐allergic mattress encasing may provide clinical benefit in asthmatic patients. However, the effect of mattress encasings on allergen‐specific parameters, such as bronchial reactions to house dust mite (HDM) challenge, is not clear.
Objective To investigate the effect of anti‐allergic mattress encasings on allergen sensitivity in patients with moderate to severe asthma.
Methods Twenty‐seven patients with asthma and HDM allergy were studied in a double‐blind, placebo‐controlled study. Concentrations of Dermatophagoides pteronyssinus (Der p 1) were measured in mattress dust before and after 1 year of treatment; bronchial histamine challenge, bronchial challenge with HDM and intradermal skin challenges with HDM were performed. The number of eosinophils in peripheral blood was assessed.
Results In the active group, but not in the placebo group, there was a significant reduction in Der p 1 concentration in the dust collected from the mattresses after 1 year of treatment compared to before. There was a significant difference between the groups with respect to HDM‐induced early‐reaction (ER) in the airways and the number of blood eosinophils, which reflected an increase in ER and eosinophils in the placebo group without significant change in the active group. No significant improvement in PC20 histamine, late‐reaction (LR) and skin tests was found in either groups.
Conclusion Our data suggest that encasings protect against a further increase in allergen sensitivity in asthmatic patients, so their use should be recommended.</description><subject>Adolescent</subject><subject>Adult</subject><subject>allergic asthma</subject><subject>Allergic diseases</subject><subject>Animals</subject><subject>Antigens, Dermatophagoides</subject><subject>Asthma - immunology</subject><subject>Asthma - physiopathology</subject><subject>Bedding and Linens</subject><subject>Biological and medical sciences</subject><subject>bronchial allergen challenge</subject><subject>Child</subject><subject>Double-Blind Method</subject><subject>Dust</subject><subject>Eosinophils - pathology</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Glycoproteins - analysis</subject><subject>Histamine Release</subject><subject>house dust mite</subject><subject>Humans</subject><subject>Hypersensitivity - immunology</subject><subject>Hypersensitivity - prevention & control</subject><subject>Immunoglobulin E - analysis</subject><subject>Immunopathology</subject><subject>Male</subject><subject>mattress encasings</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mites - immunology</subject><subject>Osmolar Concentration</subject><subject>Respiratory and ent allergic diseases</subject><subject>Skin - immunology</subject><subject>Time Factors</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc2O0zAUhSMEYsrAKyALCVY42En8kwWLqgwzSCNAYhBLy7Fvpi6pU2xH074ST4lDK0ZiA17YV9Z3ju69pygQJSUlDX-zKQmpKkwaIcqKEFoSWjFe7h8UC1pzhqt8HhYL0rIGC9k2Z8WTGDeEkJq18nFxRrOoEpVcFD9v1oCg78EkNPZI--SwHgYIt86grU4pQIwIvNHR-duIRo_W4xQB2SkmtHUJsPN2MmAR6DAccLawaND5X7twpw8ogDbJjT4i55GOaZ1ds_cu3-BTLNES2XHqBsDdkK1eo92gDXQjNqNPYcy9WBTTZA9Pi0e9HiI8O73nxdf3FzerK3z96fLDanmNDWOC447ZloNgPC-i440VsmFWQNcJaKkVtAap-8YQYQ1IoLrRmjHNKWOk5rzu6vPi1dF3F8YfE8Skti4aGAbtIY-uBOWi4g39J0hlQ9qWVBl88Re4Gafg8xCKtq1s21rKDMkjZMIYY4Be7YLb6nBQlKg5dbVRc-pqTl3Nqavfqat9lj4_-U_dFuy98BRzBl6eAB2NHvqgvXHxnquFkKSeubdH7s4NcPjvBtTqYjlXWY-PehcT7P_odfiuuKgFU98-Xqr23Wcur8QXVde_AEM32PI</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Rijssenbeek-Nouwens, L. H. M.</creator><creator>Oosting, A. J.</creator><creator>De Monchy, J. G. R.</creator><creator>Bregman, I.</creator><creator>Postma, D. S.</creator><creator>De Bruin-Weller, M. S.</creator><general>Blackwell Science, Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>The effect of anti-allergic mattress encasings on house dust mite-induced early- and late-airway reactions in asthmatic patients. A double-blind, placebo-controlled study</title><author>Rijssenbeek-Nouwens, L. H. M. ; Oosting, A. J. ; De Monchy, J. G. R. ; Bregman, I. ; Postma, D. S. ; De Bruin-Weller, M. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5576-b5d96e756365b64d7845d7ebb7e91d713e8af4c07dce8e1a4aa55a615503663b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>allergic asthma</topic><topic>Allergic diseases</topic><topic>Animals</topic><topic>Antigens, Dermatophagoides</topic><topic>Asthma - immunology</topic><topic>Asthma - physiopathology</topic><topic>Bedding and Linens</topic><topic>Biological and medical sciences</topic><topic>bronchial allergen challenge</topic><topic>Child</topic><topic>Double-Blind Method</topic><topic>Dust</topic><topic>Eosinophils - pathology</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Glycoproteins - analysis</topic><topic>Histamine Release</topic><topic>house dust mite</topic><topic>Humans</topic><topic>Hypersensitivity - immunology</topic><topic>Hypersensitivity - prevention & control</topic><topic>Immunoglobulin E - analysis</topic><topic>Immunopathology</topic><topic>Male</topic><topic>mattress encasings</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mites - immunology</topic><topic>Osmolar Concentration</topic><topic>Respiratory and ent allergic diseases</topic><topic>Skin - immunology</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rijssenbeek-Nouwens, L. H. M.</creatorcontrib><creatorcontrib>Oosting, A. J.</creatorcontrib><creatorcontrib>De Monchy, J. G. R.</creatorcontrib><creatorcontrib>Bregman, I.</creatorcontrib><creatorcontrib>Postma, D. S.</creatorcontrib><creatorcontrib>De Bruin-Weller, M. S.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rijssenbeek-Nouwens, L. H. M.</au><au>Oosting, A. J.</au><au>De Monchy, J. G. R.</au><au>Bregman, I.</au><au>Postma, D. S.</au><au>De Bruin-Weller, M. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of anti-allergic mattress encasings on house dust mite-induced early- and late-airway reactions in asthmatic patients. A double-blind, placebo-controlled study</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2002-01</date><risdate>2002</risdate><volume>32</volume><issue>1</issue><spage>117</spage><epage>125</epage><pages>117-125</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Background Anti‐allergic mattress encasing may provide clinical benefit in asthmatic patients. However, the effect of mattress encasings on allergen‐specific parameters, such as bronchial reactions to house dust mite (HDM) challenge, is not clear.
Objective To investigate the effect of anti‐allergic mattress encasings on allergen sensitivity in patients with moderate to severe asthma.
Methods Twenty‐seven patients with asthma and HDM allergy were studied in a double‐blind, placebo‐controlled study. Concentrations of Dermatophagoides pteronyssinus (Der p 1) were measured in mattress dust before and after 1 year of treatment; bronchial histamine challenge, bronchial challenge with HDM and intradermal skin challenges with HDM were performed. The number of eosinophils in peripheral blood was assessed.
Results In the active group, but not in the placebo group, there was a significant reduction in Der p 1 concentration in the dust collected from the mattresses after 1 year of treatment compared to before. There was a significant difference between the groups with respect to HDM‐induced early‐reaction (ER) in the airways and the number of blood eosinophils, which reflected an increase in ER and eosinophils in the placebo group without significant change in the active group. No significant improvement in PC20 histamine, late‐reaction (LR) and skin tests was found in either groups.
Conclusion Our data suggest that encasings protect against a further increase in allergen sensitivity in asthmatic patients, so their use should be recommended.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science, Ltd</pub><pmid>12002728</pmid><doi>10.1046/j.0022-0477.2001.01256.x</doi><tpages>9</tpages></addata></record> |
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subjects | Adolescent Adult allergic asthma Allergic diseases Animals Antigens, Dermatophagoides Asthma - immunology Asthma - physiopathology Bedding and Linens Biological and medical sciences bronchial allergen challenge Child Double-Blind Method Dust Eosinophils - pathology Female Forced Expiratory Volume Glycoproteins - analysis Histamine Release house dust mite Humans Hypersensitivity - immunology Hypersensitivity - prevention & control Immunoglobulin E - analysis Immunopathology Male mattress encasings Medical sciences Middle Aged Mites - immunology Osmolar Concentration Respiratory and ent allergic diseases Skin - immunology Time Factors |
title | The effect of anti-allergic mattress encasings on house dust mite-induced early- and late-airway reactions in asthmatic patients. A double-blind, placebo-controlled study |
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