Immunoprotective steroids and SHBG in non-treated hypothyroidism and their relationship to autoimmune thyroid disorders
Immunomodulatory steroids, dehydroepiandrosterone and its 7-hydroxylated metabolites and sex hormone-binding globulin (SHBG) were determined in sera of 88 women aged 18-75 years. The group consisted of 34 healthy women, 37 women with subclinical and 17 women with manifest hypothyroidism. In all subj...
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| Veröffentlicht in: | Physiological research 2008, Vol.57 Suppl 1, p.S119-S125 |
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| creator | Drbalová, K Matucha, P Matejková-Behanová, M Bílek, R Kríz, L Kazihnitková, H Hampl, R |
| description | Immunomodulatory steroids, dehydroepiandrosterone and its 7-hydroxylated metabolites and sex hormone-binding globulin (SHBG) were determined in sera of 88 women aged 18-75 years. The group consisted of 34 healthy women, 37 women with subclinical and 17 women with manifest hypothyroidism. In all subjects the laboratory parameters of thyroid function (thyrotropin, free thyroxine and triiodothyronine) and thyroid autoantibodies to thyroid peroxidase and thyroglobulin were determined. The aim was to find out 1) whether the above steroids and SHBG levels differ in individual groups according to thyroid status, 2) whether correlations exist among investigated steroids and thyroid laboratory parameters, and 3) whether the respective steroid and SHBG levels differ according to the presence of principal thyroid autoantibodies. With the exception of 7beta-hydroxy-dehydroepindrosterone levels, which were decreased in patients with manifest hypothyroidism (p |
| doi_str_mv | 10.33549/physiolres.931496 |
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The group consisted of 34 healthy women, 37 women with subclinical and 17 women with manifest hypothyroidism. In all subjects the laboratory parameters of thyroid function (thyrotropin, free thyroxine and triiodothyronine) and thyroid autoantibodies to thyroid peroxidase and thyroglobulin were determined. The aim was to find out 1) whether the above steroids and SHBG levels differ in individual groups according to thyroid status, 2) whether correlations exist among investigated steroids and thyroid laboratory parameters, and 3) whether the respective steroid and SHBG levels differ according to the presence of principal thyroid autoantibodies. With the exception of 7beta-hydroxy-dehydroepindrosterone levels, which were decreased in patients with manifest hypothyroidism (p<0.05), no significant differences in steroid and SHBG levels among groups according to diagnosis were found. On the other hand, significantly decreased levels of all the immunomodulatory steroids studied were found in subjects with positive titres of thyroid autoantibodies. This finding was supported by a tight negative correlation among the above steroids and thyroid autoantibodies. In addition, these steroids correlated negatively with thyrotropin and positively with free thyroid hormones. The results point to a negative relationship between the above mentioned immunoprotective steroids and the extent of the autoimmune process in hypothyroidism.</description><identifier>ISSN: 0862-8408</identifier><identifier>EISSN: 1802-9973</identifier><identifier>DOI: 10.33549/physiolres.931496</identifier><identifier>PMID: 18271685</identifier><language>eng</language><publisher>Czech Republic: Institute of Physiology</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Autoimmune diseases ; Autoimmunity - physiology ; Dehydroepiandrosterone - analogs & derivatives ; Dehydroepiandrosterone - blood ; Female ; Hormones ; Humans ; Hypothyroidism ; Hypothyroidism - immunology ; Hypothyroidism - metabolism ; Middle Aged ; Older people ; Patients ; Sex Hormone-Binding Globulin - metabolism ; Steroids ; Thyroid gland ; Thyroid Hormones - blood ; Thyroiditis, Autoimmune - immunology ; Thyroiditis, Autoimmune - metabolism ; Thyrotropin - blood ; Thyroxine - blood ; Triiodothyronine - blood</subject><ispartof>Physiological research, 2008, Vol.57 Suppl 1, p.S119-S125</ispartof><rights>Copyright Institute of Physiology 2008</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c372t-52a691516bccbb0504dfa4942d487c931110dfb0724ae70d50a9728ab5b6707e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18271685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Drbalová, K</creatorcontrib><creatorcontrib>Matucha, P</creatorcontrib><creatorcontrib>Matejková-Behanová, M</creatorcontrib><creatorcontrib>Bílek, R</creatorcontrib><creatorcontrib>Kríz, L</creatorcontrib><creatorcontrib>Kazihnitková, H</creatorcontrib><creatorcontrib>Hampl, R</creatorcontrib><title>Immunoprotective steroids and SHBG in non-treated hypothyroidism and their relationship to autoimmune thyroid disorders</title><title>Physiological research</title><addtitle>Physiol Res</addtitle><description>Immunomodulatory steroids, dehydroepiandrosterone and its 7-hydroxylated metabolites and sex hormone-binding globulin (SHBG) were determined in sera of 88 women aged 18-75 years. The group consisted of 34 healthy women, 37 women with subclinical and 17 women with manifest hypothyroidism. In all subjects the laboratory parameters of thyroid function (thyrotropin, free thyroxine and triiodothyronine) and thyroid autoantibodies to thyroid peroxidase and thyroglobulin were determined. The aim was to find out 1) whether the above steroids and SHBG levels differ in individual groups according to thyroid status, 2) whether correlations exist among investigated steroids and thyroid laboratory parameters, and 3) whether the respective steroid and SHBG levels differ according to the presence of principal thyroid autoantibodies. With the exception of 7beta-hydroxy-dehydroepindrosterone levels, which were decreased in patients with manifest hypothyroidism (p<0.05), no significant differences in steroid and SHBG levels among groups according to diagnosis were found. On the other hand, significantly decreased levels of all the immunomodulatory steroids studied were found in subjects with positive titres of thyroid autoantibodies. This finding was supported by a tight negative correlation among the above steroids and thyroid autoantibodies. In addition, these steroids correlated negatively with thyrotropin and positively with free thyroid hormones. The results point to a negative relationship between the above mentioned immunoprotective steroids and the extent of the autoimmune process in hypothyroidism.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Autoimmune diseases</subject><subject>Autoimmunity - physiology</subject><subject>Dehydroepiandrosterone - analogs & derivatives</subject><subject>Dehydroepiandrosterone - blood</subject><subject>Female</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypothyroidism</subject><subject>Hypothyroidism - immunology</subject><subject>Hypothyroidism - metabolism</subject><subject>Middle Aged</subject><subject>Older people</subject><subject>Patients</subject><subject>Sex Hormone-Binding Globulin - metabolism</subject><subject>Steroids</subject><subject>Thyroid gland</subject><subject>Thyroid Hormones - blood</subject><subject>Thyroiditis, Autoimmune - immunology</subject><subject>Thyroiditis, Autoimmune - metabolism</subject><subject>Thyrotropin - blood</subject><subject>Thyroxine - blood</subject><subject>Triiodothyronine - blood</subject><issn>0862-8408</issn><issn>1802-9973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkc1KxDAYRYMozvjzAi4kuHBXTdKkSZc6-AeCC3Vd0uYbGmmbmqRK397oDAy4yubcy3dzEDqj5CrPBS-vx3YO1nUewlWZU14We2hJFWFZWcp8Hy2JKlimOFELdBTCByFMEpkfogVVTNJCiSX6fur7aXCjdxGaaL8AhwjeWROwHgx-fbx9wHbAgxuy6EFHMLidRxfb-Reyof_DYgvWYw-djtYNobUjjg7rKTr7Ww94y-OUcN6ADyfoYK27AKfb9xi939-9rR6z55eHp9XNc9bkksVMMF2UVNCibpq6JoJws9a85MxwJZs0mlJi1jWRjGuQxAiiS8mUrkVdpK2QH6PLTW9a-DlBiFVvQwNdpwdwU6jSN0iiBEngxT_ww01-SLdVjDLGC1HwBLEN1HgXgod1NXrbaz9XlFR_Tqqdk2rjJIXOt81T3YPZRbYS8h_OxI00</recordid><startdate>2008</startdate><enddate>2008</enddate><creator>Drbalová, K</creator><creator>Matucha, P</creator><creator>Matejková-Behanová, M</creator><creator>Bílek, R</creator><creator>Kríz, L</creator><creator>Kazihnitková, H</creator><creator>Hampl, R</creator><general>Institute of Physiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>4T-</scope><scope>4U-</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BYOGL</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>2008</creationdate><title>Immunoprotective steroids and SHBG in non-treated hypothyroidism and their relationship to autoimmune thyroid disorders</title><author>Drbalová, K ; Matucha, P ; Matejková-Behanová, M ; Bílek, R ; Kríz, L ; Kazihnitková, H ; Hampl, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c372t-52a691516bccbb0504dfa4942d487c931110dfb0724ae70d50a9728ab5b6707e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Autoimmune diseases</topic><topic>Autoimmunity - physiology</topic><topic>Dehydroepiandrosterone - analogs & derivatives</topic><topic>Dehydroepiandrosterone - blood</topic><topic>Female</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hypothyroidism</topic><topic>Hypothyroidism - immunology</topic><topic>Hypothyroidism - metabolism</topic><topic>Middle Aged</topic><topic>Older people</topic><topic>Patients</topic><topic>Sex Hormone-Binding Globulin - metabolism</topic><topic>Steroids</topic><topic>Thyroid gland</topic><topic>Thyroid Hormones - blood</topic><topic>Thyroiditis, Autoimmune - immunology</topic><topic>Thyroiditis, Autoimmune - metabolism</topic><topic>Thyrotropin - blood</topic><topic>Thyroxine - blood</topic><topic>Triiodothyronine - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Drbalová, K</creatorcontrib><creatorcontrib>Matucha, P</creatorcontrib><creatorcontrib>Matejková-Behanová, M</creatorcontrib><creatorcontrib>Bílek, R</creatorcontrib><creatorcontrib>Kríz, L</creatorcontrib><creatorcontrib>Kazihnitková, H</creatorcontrib><creatorcontrib>Hampl, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Docstoc</collection><collection>University Readers</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>East Europe, Central Europe Database</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Physiological research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Drbalová, K</au><au>Matucha, P</au><au>Matejková-Behanová, M</au><au>Bílek, R</au><au>Kríz, L</au><au>Kazihnitková, H</au><au>Hampl, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoprotective steroids and SHBG in non-treated hypothyroidism and their relationship to autoimmune thyroid disorders</atitle><jtitle>Physiological research</jtitle><addtitle>Physiol Res</addtitle><date>2008</date><risdate>2008</risdate><volume>57 Suppl 1</volume><spage>S119</spage><epage>S125</epage><pages>S119-S125</pages><issn>0862-8408</issn><eissn>1802-9973</eissn><abstract>Immunomodulatory steroids, dehydroepiandrosterone and its 7-hydroxylated metabolites and sex hormone-binding globulin (SHBG) were determined in sera of 88 women aged 18-75 years. The group consisted of 34 healthy women, 37 women with subclinical and 17 women with manifest hypothyroidism. In all subjects the laboratory parameters of thyroid function (thyrotropin, free thyroxine and triiodothyronine) and thyroid autoantibodies to thyroid peroxidase and thyroglobulin were determined. The aim was to find out 1) whether the above steroids and SHBG levels differ in individual groups according to thyroid status, 2) whether correlations exist among investigated steroids and thyroid laboratory parameters, and 3) whether the respective steroid and SHBG levels differ according to the presence of principal thyroid autoantibodies. With the exception of 7beta-hydroxy-dehydroepindrosterone levels, which were decreased in patients with manifest hypothyroidism (p<0.05), no significant differences in steroid and SHBG levels among groups according to diagnosis were found. On the other hand, significantly decreased levels of all the immunomodulatory steroids studied were found in subjects with positive titres of thyroid autoantibodies. This finding was supported by a tight negative correlation among the above steroids and thyroid autoantibodies. In addition, these steroids correlated negatively with thyrotropin and positively with free thyroid hormones. The results point to a negative relationship between the above mentioned immunoprotective steroids and the extent of the autoimmune process in hypothyroidism.</abstract><cop>Czech Republic</cop><pub>Institute of Physiology</pub><pmid>18271685</pmid><doi>10.33549/physiolres.931496</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Autoimmune diseases Autoimmunity - physiology Dehydroepiandrosterone - analogs & derivatives Dehydroepiandrosterone - blood Female Hormones Humans Hypothyroidism Hypothyroidism - immunology Hypothyroidism - metabolism Middle Aged Older people Patients Sex Hormone-Binding Globulin - metabolism Steroids Thyroid gland Thyroid Hormones - blood Thyroiditis, Autoimmune - immunology Thyroiditis, Autoimmune - metabolism Thyrotropin - blood Thyroxine - blood Triiodothyronine - blood |
| title | Immunoprotective steroids and SHBG in non-treated hypothyroidism and their relationship to autoimmune thyroid disorders |
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