Ocular drug permeation following experimental excimer laser treatment on the isolated pig eye
Excimer laser photorefractive keratectomy (PRK) is a well-established procedure which is frequently applied to correct myopia. Since structural alterations of the corneal epithelium occur after the treatment, a different drug permeation can be assumed. To investigate the effects of PRK on drug perme...
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| Veröffentlicht in: | Journal of ocular pharmacology and therapeutics 2002-04, Vol.18 (2), p.177-183 |
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| container_title | Journal of ocular pharmacology and therapeutics |
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| creator | SCHOLZ, Martina SCHRÜNDER, Stephan GÄRTNER, Sven KEIPERT, Sigrid HARTMANN, Christian PLEYER, Uwe |
| description | Excimer laser photorefractive keratectomy (PRK) is a well-established procedure which is frequently applied to correct myopia. Since structural alterations of the corneal epithelium occur after the treatment, a different drug permeation can be assumed. To investigate the effects of PRK on drug permeation, excimer laser ablations with varying depths were performed on isolated pig eyes. The permeation of lipophilic (diclofenac-sodium; D-Na) and hydrophilic (pilocarpine-hydrochloride; P-HCl model drugs were studied in vitro. Under these experimental conditions, P-HCl demonstrated a significant (p < 0.05) enhancement of permeation in relation to the ablation depth. In contrast, corneal epithelial thickness scarcely influenced the permeation rate of D-Na. Not until removing the entire epithelium did a significantly increased permeability occur, when compared to untreated cornea. These results suggest that PRK may significantly reduce the corneal barrier function and alter pharmacokinetics of topical medication. |
| doi_str_mv | 10.1089/108076802317373923 |
| format | Article |
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Since structural alterations of the corneal epithelium occur after the treatment, a different drug permeation can be assumed. To investigate the effects of PRK on drug permeation, excimer laser ablations with varying depths were performed on isolated pig eyes. The permeation of lipophilic (diclofenac-sodium; D-Na) and hydrophilic (pilocarpine-hydrochloride; P-HCl model drugs were studied in vitro. Under these experimental conditions, P-HCl demonstrated a significant (p < 0.05) enhancement of permeation in relation to the ablation depth. In contrast, corneal epithelial thickness scarcely influenced the permeation rate of D-Na. Not until removing the entire epithelium did a significantly increased permeability occur, when compared to untreated cornea. These results suggest that PRK may significantly reduce the corneal barrier function and alter pharmacokinetics of topical medication.</description><identifier>ISSN: 1080-7683</identifier><identifier>EISSN: 1557-7732</identifier><identifier>DOI: 10.1089/108076802317373923</identifier><identifier>PMID: 12002670</identifier><language>eng</language><publisher>Larchmont, NY: Liebert</publisher><subject>Animals ; Biological and medical sciences ; Diclofenac - pharmacokinetics ; Eye ; Eye - metabolism ; In Vitro Techniques ; Laser Therapy ; Medical sciences ; Miscellaneous ; Ophthalmic Solutions - pharmacokinetics ; Ophthalmologic Surgical Procedures ; Ophthalmology ; Permeability ; Pharmacology. 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Since structural alterations of the corneal epithelium occur after the treatment, a different drug permeation can be assumed. To investigate the effects of PRK on drug permeation, excimer laser ablations with varying depths were performed on isolated pig eyes. The permeation of lipophilic (diclofenac-sodium; D-Na) and hydrophilic (pilocarpine-hydrochloride; P-HCl model drugs were studied in vitro. Under these experimental conditions, P-HCl demonstrated a significant (p < 0.05) enhancement of permeation in relation to the ablation depth. In contrast, corneal epithelial thickness scarcely influenced the permeation rate of D-Na. Not until removing the entire epithelium did a significantly increased permeability occur, when compared to untreated cornea. These results suggest that PRK may significantly reduce the corneal barrier function and alter pharmacokinetics of topical medication.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Diclofenac - pharmacokinetics</subject><subject>Eye</subject><subject>Eye - metabolism</subject><subject>In Vitro Techniques</subject><subject>Laser Therapy</subject><subject>Medical sciences</subject><subject>Miscellaneous</subject><subject>Ophthalmic Solutions - pharmacokinetics</subject><subject>Ophthalmologic Surgical Procedures</subject><subject>Ophthalmology</subject><subject>Permeability</subject><subject>Pharmacology. Drug treatments</subject><subject>Pilocarpine - pharmacokinetics</subject><subject>Swine</subject><issn>1080-7683</issn><issn>1557-7732</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNplkMtOwzAQRS0EoqXwAyyQN7ALjO0kTpcI8ZIqddMtihx7XIKcB3Yi6N_jqpG6YDMPz7kjzyXkmsE9g2L5EAPIvAAumBRSLLk4IXOWZTKRUvDTWEcgiYSYkYsQvgCYgJydkxnjADyXMCcfaz065anx45b26BtUQ9211HbOdT91u6X4G5_rBttBudjoWHrqVIhx8JHeT2hUDJ9I69A5NaChfR2FO7wkZ1a5gFdTXpDNy_Pm6S1ZrV_fnx5XiU55OiQaGLdWYGZswa0CIViRsoqrSgMWFdgi1aYq9p82Ms-kYTyTlVIGqzznIBbk7rC29933iGEomzpodE612I2hlCzeWkAaQX4Ate9C8GjLPp6m_K5kUO49Lf97GkU30_axatAcJZOJEbidABW0ctarVtfhyImcZylj4g8K3n-C</recordid><startdate>20020401</startdate><enddate>20020401</enddate><creator>SCHOLZ, Martina</creator><creator>SCHRÜNDER, Stephan</creator><creator>GÄRTNER, Sven</creator><creator>KEIPERT, Sigrid</creator><creator>HARTMANN, Christian</creator><creator>PLEYER, Uwe</creator><general>Liebert</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020401</creationdate><title>Ocular drug permeation following experimental excimer laser treatment on the isolated pig eye</title><author>SCHOLZ, Martina ; SCHRÜNDER, Stephan ; GÄRTNER, Sven ; KEIPERT, Sigrid ; HARTMANN, Christian ; PLEYER, Uwe</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c424t-c012ff3e5df82fa0331841b2abc0e8b0f84cdb82002d7657d1257baadeb66203</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Diclofenac - pharmacokinetics</topic><topic>Eye</topic><topic>Eye - metabolism</topic><topic>In Vitro Techniques</topic><topic>Laser Therapy</topic><topic>Medical sciences</topic><topic>Miscellaneous</topic><topic>Ophthalmic Solutions - pharmacokinetics</topic><topic>Ophthalmologic Surgical Procedures</topic><topic>Ophthalmology</topic><topic>Permeability</topic><topic>Pharmacology. Drug treatments</topic><topic>Pilocarpine - pharmacokinetics</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SCHOLZ, Martina</creatorcontrib><creatorcontrib>SCHRÜNDER, Stephan</creatorcontrib><creatorcontrib>GÄRTNER, Sven</creatorcontrib><creatorcontrib>KEIPERT, Sigrid</creatorcontrib><creatorcontrib>HARTMANN, Christian</creatorcontrib><creatorcontrib>PLEYER, Uwe</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of ocular pharmacology and therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SCHOLZ, Martina</au><au>SCHRÜNDER, Stephan</au><au>GÄRTNER, Sven</au><au>KEIPERT, Sigrid</au><au>HARTMANN, Christian</au><au>PLEYER, Uwe</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ocular drug permeation following experimental excimer laser treatment on the isolated pig eye</atitle><jtitle>Journal of ocular pharmacology and therapeutics</jtitle><addtitle>J Ocul Pharmacol Ther</addtitle><date>2002-04-01</date><risdate>2002</risdate><volume>18</volume><issue>2</issue><spage>177</spage><epage>183</epage><pages>177-183</pages><issn>1080-7683</issn><eissn>1557-7732</eissn><abstract>Excimer laser photorefractive keratectomy (PRK) is a well-established procedure which is frequently applied to correct myopia. Since structural alterations of the corneal epithelium occur after the treatment, a different drug permeation can be assumed. To investigate the effects of PRK on drug permeation, excimer laser ablations with varying depths were performed on isolated pig eyes. The permeation of lipophilic (diclofenac-sodium; D-Na) and hydrophilic (pilocarpine-hydrochloride; P-HCl model drugs were studied in vitro. Under these experimental conditions, P-HCl demonstrated a significant (p < 0.05) enhancement of permeation in relation to the ablation depth. In contrast, corneal epithelial thickness scarcely influenced the permeation rate of D-Na. Not until removing the entire epithelium did a significantly increased permeability occur, when compared to untreated cornea. These results suggest that PRK may significantly reduce the corneal barrier function and alter pharmacokinetics of topical medication.</abstract><cop>Larchmont, NY</cop><pub>Liebert</pub><pmid>12002670</pmid><doi>10.1089/108076802317373923</doi><tpages>7</tpages></addata></record> |
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| source | Mary Ann Liebert Online Subscription; MEDLINE |
| subjects | Animals Biological and medical sciences Diclofenac - pharmacokinetics Eye Eye - metabolism In Vitro Techniques Laser Therapy Medical sciences Miscellaneous Ophthalmic Solutions - pharmacokinetics Ophthalmologic Surgical Procedures Ophthalmology Permeability Pharmacology. Drug treatments Pilocarpine - pharmacokinetics Swine |
| title | Ocular drug permeation following experimental excimer laser treatment on the isolated pig eye |
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