The antidepressant-like effects of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) in mice

The aim of the present work is to evaluate the putative antidepressant-like effects of a hydro-ethanolic extract (CEAp) and their fractions from the aerial parts of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) on the performance of male mice in the forced swimming test (FST). A single dose (...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2008-06, Vol.15 (6), p.478-483
Hauptverfasser:	Hellión-Ibarrola, M.C., Ibarrola, D.A., Montalbetti, Y., Kennedy, M.L., Heinichen, O., Campuzano, M., Ferro, E.A., Alvarenga, N., Tortoriello, J., De Lima, T.C.M., Mora, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aloysia polystachya Animals Antidepressant effect Antidepressive Agents - analysis Depression - drug therapy Forced swimming test Immobility Immobility Response, Tonic - drug effects Male Mice Phytotherapy Plant Extracts - administration & dosage Stress, Psychological - drug therapy Swimming - psychology Verbenaceae Verbenaceae - chemistry
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Zusammenfassung:	The aim of the present work is to evaluate the putative antidepressant-like effects of a hydro-ethanolic extract (CEAp) and their fractions from the aerial parts of Aloysia polystachya (Griseb.) Moldenke (Verbenaceae) on the performance of male mice in the forced swimming test (FST). A single dose (100.0 mg/kg p.o.) of CEAp, in male mice provoked a significant reduction of the immobility time ( p
ISSN:	0944-7113 1618-095X
DOI:	10.1016/j.phymed.2007.11.018