P2X7 receptor as sensitive flow sensor for ERK activation in osteoblasts

The involvement of the P2 receptor in the activation of ERK induced by a short transient fluid flow stimulation in MC3T3-E1 osteoblasts was examined in the current study. The ERK activation induced by this transient fluid flow stimulation was followed by an increase in c-fos mRNA expression. Suramin...

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Veröffentlicht in:	Biochemical and biophysical research communications 2008-08, Vol.372 (3), p.486-490
Hauptverfasser:	Okumura, Hisashi, Shiba, Dai, Kubo, Toshikazu, Yokoyama, Takahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphate - analogs & derivatives Adenosine Triphosphate - pharmacology Animals BBG Cell Line ERK Estrenes - pharmacology Extracellular Signal-Regulated MAP Kinases - metabolism Fluid flow Fos Inhibitor Mechanical stress Mice Osteoblast Osteoblasts - drug effects Osteoblasts - metabolism Oxidized ATP P2X7 Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - metabolism Purinergic P2 Receptor Agonists Purinergic P2 Receptor Antagonists Pyrrolidinones - pharmacology Receptors, Purinergic P2 - metabolism Receptors, Purinergic P2X7 RNA, Messenger - metabolism Stress, Mechanical Suramin - pharmacology
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