Fast Biphasic Regulation of Type 3 Inositol Trisphosphate Receptors by Cytosolic Calcium

In cytosol-like medium (CLM) with a free [Ca2+] of 200 nm, a supramaximal concentration of inositol 1,4,5-trisphosphate (IP3) (30 μm) evoked 45Ca2+ release from type 3 IP3 receptors only after a latency of 48 ± 6 ms; this latency could not be reduced by increasing the IP3concentration. In CLM contai...

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Veröffentlicht in:	The Journal of biological chemistry 2002-05, Vol.277 (20), p.17571-17579
Hauptverfasser:	Swatton, Jane E., Taylor, Colin W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium - physiology Calcium Channels - physiology Cells, Cultured Cytosol - metabolism Inositol 1,4,5-Trisphosphate - analogs & derivatives Inositol 1,4,5-Trisphosphate - metabolism Inositol 1,4,5-Trisphosphate Receptors Kinetics Liver - metabolism Rats Receptors, Cytoplasmic and Nuclear - physiology Tumor Cells, Cultured
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