Metabolic replacement of kidney function in uremic animals with a bioartificial kidney containing human cells
Current renal substitution therapy with hemodialysis or hemofiltration has been an important life-sustaining technology, but it still has suboptimal clinical outcomes in patients with end-stage renal disease or acute renal failure. This therapy replaces the small solute clearance function of the glo...
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| Veröffentlicht in: | American journal of kidney diseases 2002-05, Vol.39 (5), p.1078-1087 |
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| container_title | American journal of kidney diseases |
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| creator | Humes, H.David Fissell, William H. Weitzel, William F. Buffington, Deborah A. Westover, Angela J. MacKay, Sherrill M. Gutierrez, Jorge M. |
| description | Current renal substitution therapy with hemodialysis or hemofiltration has been an important life-sustaining technology, but it still has suboptimal clinical outcomes in patients with end-stage renal disease or acute renal failure. This therapy replaces the small solute clearance function of the glomerulus but does not replace the metabolic and endocrinologic functions of the tubular cells. This article shows that the combination of a synthetic hemofiltration cartridge and a renal tubule cell assist device (RAD) containing human cells in an extracorporeal circuit replaces filtration, metabolic, and endocrinologic functions in acutely uremic dogs. The RAD maintained excellent performance and durability characteristics for 24 hours of continuous use in the uremic animals. The RAD increased ammonia excretion, glutathione metabolism, and 1,25-dihydroxyvitamin D3 production. Cardiovascular stability in the animals was documented in these studies during this extracorporeal treatment. With these results, clinical evaluation of this device in the treatment of severely ill patients with acute renal failure in an intensive care unit has been initiated. © 2002 by the National Kidney Foundation, Inc. |
| doi_str_mv | 10.1053/ajkd.2002.32792 |
| format | Article |
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This therapy replaces the small solute clearance function of the glomerulus but does not replace the metabolic and endocrinologic functions of the tubular cells. This article shows that the combination of a synthetic hemofiltration cartridge and a renal tubule cell assist device (RAD) containing human cells in an extracorporeal circuit replaces filtration, metabolic, and endocrinologic functions in acutely uremic dogs. The RAD maintained excellent performance and durability characteristics for 24 hours of continuous use in the uremic animals. The RAD increased ammonia excretion, glutathione metabolism, and 1,25-dihydroxyvitamin D3 production. Cardiovascular stability in the animals was documented in these studies during this extracorporeal treatment. 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Dialysis management ; Endocrine Glands - cytology ; Endocrine Glands - physiology ; Hemofiltration - instrumentation ; Hemofiltration - methods ; Hemofiltration - trends ; Humans ; Intensive care medicine ; Kidney tubule cells ; Kidney Tubules, Proximal - cytology ; Kidney Tubules, Proximal - metabolism ; Kidney Tubules, Proximal - physiology ; Kidneys, Artificial - standards ; Kidneys, Artificial - trends ; Lymphocyte Count ; Medical sciences ; Renal Replacement Therapy - instrumentation ; Renal Replacement Therapy - methods ; Renal Replacement Therapy - trends ; Swine ; tissue engineering ; Uremia - therapy</subject><ispartof>American journal of kidney diseases, 2002-05, Vol.39 (5), p.1078-1087</ispartof><rights>2002 National Kidney Foundation, Inc</rights><rights>2002 INIST-CNRS</rights><rights>Copyright 2002 by the National Kidney Foundation, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-f0f25cd6f458ca394fcc863524c4320c16bfd5fc15c539e3ead3230e4d3ff7353</citedby><cites>FETCH-LOGICAL-c373t-f0f25cd6f458ca394fcc863524c4320c16bfd5fc15c539e3ead3230e4d3ff7353</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1053/ajkd.2002.32792$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13650739$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11979353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Humes, H.David</creatorcontrib><creatorcontrib>Fissell, William H.</creatorcontrib><creatorcontrib>Weitzel, William F.</creatorcontrib><creatorcontrib>Buffington, Deborah A.</creatorcontrib><creatorcontrib>Westover, Angela J.</creatorcontrib><creatorcontrib>MacKay, Sherrill M.</creatorcontrib><creatorcontrib>Gutierrez, Jorge M.</creatorcontrib><title>Metabolic replacement of kidney function in uremic animals with a bioartificial kidney containing human cells</title><title>American journal of kidney diseases</title><addtitle>Am J Kidney Dis</addtitle><description>Current renal substitution therapy with hemodialysis or hemofiltration has been an important life-sustaining technology, but it still has suboptimal clinical outcomes in patients with end-stage renal disease or acute renal failure. This therapy replaces the small solute clearance function of the glomerulus but does not replace the metabolic and endocrinologic functions of the tubular cells. This article shows that the combination of a synthetic hemofiltration cartridge and a renal tubule cell assist device (RAD) containing human cells in an extracorporeal circuit replaces filtration, metabolic, and endocrinologic functions in acutely uremic dogs. The RAD maintained excellent performance and durability characteristics for 24 hours of continuous use in the uremic animals. The RAD increased ammonia excretion, glutathione metabolism, and 1,25-dihydroxyvitamin D3 production. Cardiovascular stability in the animals was documented in these studies during this extracorporeal treatment. With these results, clinical evaluation of this device in the treatment of severely ill patients with acute renal failure in an intensive care unit has been initiated. © 2002 by the National Kidney Foundation, Inc.</description><subject>Acute Kidney Injury - therapy</subject><subject>acute renal failure</subject><subject>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Biological Transport - physiology</subject><subject>cell therapy</subject><subject>Cells, Cultured</subject><subject>Dogs</subject><subject>Emergency and intensive care: renal failure. Dialysis management</subject><subject>Endocrine Glands - cytology</subject><subject>Endocrine Glands - physiology</subject><subject>Hemofiltration - instrumentation</subject><subject>Hemofiltration - methods</subject><subject>Hemofiltration - trends</subject><subject>Humans</subject><subject>Intensive care medicine</subject><subject>Kidney tubule cells</subject><subject>Kidney Tubules, Proximal - cytology</subject><subject>Kidney Tubules, Proximal - metabolism</subject><subject>Kidney Tubules, Proximal - physiology</subject><subject>Kidneys, Artificial - standards</subject><subject>Kidneys, Artificial - trends</subject><subject>Lymphocyte Count</subject><subject>Medical sciences</subject><subject>Renal Replacement Therapy - instrumentation</subject><subject>Renal Replacement Therapy - methods</subject><subject>Renal Replacement Therapy - trends</subject><subject>Swine</subject><subject>tissue engineering</subject><subject>Uremia - therapy</subject><issn>0272-6386</issn><issn>1523-6838</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDFvFDEQhS0EIkegpkNuoNuL7Vl7d0sUBYIURAO15ZsdEye73sP2BuXf4-MOpaKa5ntPbz7G3kqxlULDhbu7H7dKCLUF1Q3qGdtIraAxPfTP2UaoTjUGenPGXuV8J4QYwJiX7EzKoRtAw4bNX6m43TIF5In2k0OaKRa-eH4fxkiP3K8RS1giD5GvieYKuhhmN2X-O5Rb7vguLC6V4AMGN_2L4RKLCzHEn_x2nV3kSNOUX7MXvibpzemesx-frr5fXjc33z5_ufx40yB0UBovvNI4Gt_qHh0MrUfsDWjVYgtKoDQ7P2qPUqOGgYDcCAoEtSN439W_ztmHY-8-Lb9WysXOIR8WuEjLmm0nTSdE11bw4ghiWnJO5O0-1efSo5XCHgzbg2F7MGz_Gq6Jd6fqdTfT-MSflFbg_QlwGd3kk4sY8hMHRosOhsoNR46qiIdAyWYMFJHGkAiLHZfw3xF_ANRKmYI</recordid><startdate>20020501</startdate><enddate>20020501</enddate><creator>Humes, H.David</creator><creator>Fissell, William H.</creator><creator>Weitzel, William F.</creator><creator>Buffington, Deborah A.</creator><creator>Westover, Angela J.</creator><creator>MacKay, Sherrill M.</creator><creator>Gutierrez, Jorge M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20020501</creationdate><title>Metabolic replacement of kidney function in uremic animals with a bioartificial kidney containing human cells</title><author>Humes, H.David ; Fissell, William H. ; Weitzel, William F. ; Buffington, Deborah A. ; Westover, Angela J. ; MacKay, Sherrill M. ; Gutierrez, Jorge M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-f0f25cd6f458ca394fcc863524c4320c16bfd5fc15c539e3ead3230e4d3ff7353</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Acute Kidney Injury - therapy</topic><topic>acute renal failure</topic><topic>Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Biological Transport - physiology</topic><topic>cell therapy</topic><topic>Cells, Cultured</topic><topic>Dogs</topic><topic>Emergency and intensive care: renal failure. Dialysis management</topic><topic>Endocrine Glands - cytology</topic><topic>Endocrine Glands - physiology</topic><topic>Hemofiltration - instrumentation</topic><topic>Hemofiltration - methods</topic><topic>Hemofiltration - trends</topic><topic>Humans</topic><topic>Intensive care medicine</topic><topic>Kidney tubule cells</topic><topic>Kidney Tubules, Proximal - cytology</topic><topic>Kidney Tubules, Proximal - metabolism</topic><topic>Kidney Tubules, Proximal - physiology</topic><topic>Kidneys, Artificial - standards</topic><topic>Kidneys, Artificial - trends</topic><topic>Lymphocyte Count</topic><topic>Medical sciences</topic><topic>Renal Replacement Therapy - instrumentation</topic><topic>Renal Replacement Therapy - methods</topic><topic>Renal Replacement Therapy - trends</topic><topic>Swine</topic><topic>tissue engineering</topic><topic>Uremia - therapy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Humes, H.David</creatorcontrib><creatorcontrib>Fissell, William H.</creatorcontrib><creatorcontrib>Weitzel, William F.</creatorcontrib><creatorcontrib>Buffington, Deborah A.</creatorcontrib><creatorcontrib>Westover, Angela J.</creatorcontrib><creatorcontrib>MacKay, Sherrill M.</creatorcontrib><creatorcontrib>Gutierrez, Jorge M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of kidney diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Humes, H.David</au><au>Fissell, William H.</au><au>Weitzel, William F.</au><au>Buffington, Deborah A.</au><au>Westover, Angela J.</au><au>MacKay, Sherrill M.</au><au>Gutierrez, Jorge M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic replacement of kidney function in uremic animals with a bioartificial kidney containing human cells</atitle><jtitle>American journal of kidney diseases</jtitle><addtitle>Am J Kidney Dis</addtitle><date>2002-05-01</date><risdate>2002</risdate><volume>39</volume><issue>5</issue><spage>1078</spage><epage>1087</epage><pages>1078-1087</pages><issn>0272-6386</issn><eissn>1523-6838</eissn><abstract>Current renal substitution therapy with hemodialysis or hemofiltration has been an important life-sustaining technology, but it still has suboptimal clinical outcomes in patients with end-stage renal disease or acute renal failure. This therapy replaces the small solute clearance function of the glomerulus but does not replace the metabolic and endocrinologic functions of the tubular cells. This article shows that the combination of a synthetic hemofiltration cartridge and a renal tubule cell assist device (RAD) containing human cells in an extracorporeal circuit replaces filtration, metabolic, and endocrinologic functions in acutely uremic dogs. The RAD maintained excellent performance and durability characteristics for 24 hours of continuous use in the uremic animals. The RAD increased ammonia excretion, glutathione metabolism, and 1,25-dihydroxyvitamin D3 production. Cardiovascular stability in the animals was documented in these studies during this extracorporeal treatment. With these results, clinical evaluation of this device in the treatment of severely ill patients with acute renal failure in an intensive care unit has been initiated. © 2002 by the National Kidney Foundation, Inc.</abstract><cop>Orlando, FL</cop><pub>Elsevier Inc</pub><pmid>11979353</pmid><doi>10.1053/ajkd.2002.32792</doi><tpages>10</tpages></addata></record> |
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| ispartof | American journal of kidney diseases, 2002-05, Vol.39 (5), p.1078-1087 |
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| subjects | Acute Kidney Injury - therapy acute renal failure Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Animals Biological and medical sciences Biological Transport - physiology cell therapy Cells, Cultured Dogs Emergency and intensive care: renal failure. Dialysis management Endocrine Glands - cytology Endocrine Glands - physiology Hemofiltration - instrumentation Hemofiltration - methods Hemofiltration - trends Humans Intensive care medicine Kidney tubule cells Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - metabolism Kidney Tubules, Proximal - physiology Kidneys, Artificial - standards Kidneys, Artificial - trends Lymphocyte Count Medical sciences Renal Replacement Therapy - instrumentation Renal Replacement Therapy - methods Renal Replacement Therapy - trends Swine tissue engineering Uremia - therapy |
| title | Metabolic replacement of kidney function in uremic animals with a bioartificial kidney containing human cells |
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