Determination of allergenicity to three cow's milk hydrolysates and an amino acid-derived formula in children with cow's milk allergy
Background Products based on hydrolysed cow milk proteins or amino acid mixtures are recommended in children with cow's milk hypersensitivity. However, some children who are allergic to cow's milk and who clinically react to substitute milk formulas have been observed. Objective To determi...
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| Veröffentlicht in: | Clinical and experimental allergy 2002-01, Vol.32 (1), p.74-79 |
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| creator | Caffarelli, C. Plebani, A. Poiesi, C. Petroccione, T. Spattini, A. Cavagni, G. |
| description | Background Products based on hydrolysed cow milk proteins or amino acid mixtures are recommended in children with cow's milk hypersensitivity. However, some children who are allergic to cow's milk and who clinically react to substitute milk formulas have been observed.
Objective To determine the tolerance and allergenicity of protein hydrolysate or amino acid‐derived formulas in children with IgE‐mediated cow's milk allergy.
Methods Twenty children with positive cow's milk challenges, positive skin prick tests and/or serum‐specific IgE antibodies to cow's milk were selected. Oral challenges, skin prick tests and serum‐specific IgE antibodies to extensively hydrolysed whey formula, partially hydrolysed whey formula, extensively hydrolysed casein formula and amino acid‐derived formula were performed.
Results Five out of 17 (5/17) children reacted to partially hydrolysed whey formula, (3/16) to extensively hydrolysed whey formula, (2/10) to amino acid‐derived formula, (1/16) to extensively hydrolysed casein formula. Only extensively hydrolysed casein formula was tolerated by at least 90% (with 95% confidence intervals) of children. Hydrolysates provoked early and delayed clinical reactions, amino acid mixtures only delayed reactions. Partially hydrolysed whey formula elicited a significantly higher number of positive skin prick test reactions than other formulas. Two children had specific IgE antibodies to extensively hydrolysed whey formula, one to partially hydrolysed whey formula, one to extensively hydrolysed casein formula and none to amino acid‐derived formula.
Conclusion In this study, none of the cow's milk substitutes has been found to be non‐allergenic. Our results suggest that in children with IgE‐mediated cow's milk allergy, the first ingestions of extensively hydrolysed cow's milk protein formulas require strict medical supervision because of immediate reactions. This is not the case for amino acid‐derived formula. Moreover, our data suggest that treatment of children allergic to cow's milk with cow's milk substitutes should be monitored for several days to document tolerance. |
| doi_str_mv | 10.1046/j.0022-0477.2001.01262.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71668362</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>18405051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4522-94ca8dfc3f6aa50b2ff897ad43b7d9c1bc2376a43bde1e3d8b81ffde732ce1e3</originalsourceid><addsrcrecordid>eNqNkcuO0zAYhSMEYsrAKyALCVil-JLEzoLFUIaCGAGLEUhsLNf-Td1x4hk7pc0D8N44tGIQG7Bk-aLvHPvoFAUieE5w1bzYzDGmtMQV53OKMZljQhs6398pZoQ1dUnzuFvMcFtXJRdtdVI8SGmDMWZ1K-4XJySLKK_IrPjxGgaInevV4EKPgkXKe4jfoHfaDSMaAhrWEQDpsHueUOf8FVqPJgY_JjVAQqo3eSKVLQJS2pnSQHTfwSAbYrf1Crke6bXzJkKPdm5Y_2l1eGx8WNyzyid4dFxPi8s355eLt-XFx-W7xdlFqas6520rrYSxmtlGqRqvqLWi5cpUbMVNq8lKU8YblY8GCDAjVoJYa4AzqqeL0-LZwfY6hpstpEF2LmnwXvUQtkly0jSCNfSfIBEVrnFNMvjkL3ATtrHPGSRpW9EyxkWGxAHSMaQUwcrr6DoVR0mwnPqUGzn1Kac-5dSn_NWn3Gfp46P_dtWBuRUeC8zA0yOgklbeRtVrl245xrnAbEr08sDtnIfxvz8gF-dn0y7ry4PepQH2v_UqXsmGM17LLx-Wsn3_ecm-klfyE_sJmq_MmQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>199893378</pqid></control><display><type>article</type><title>Determination of allergenicity to three cow's milk hydrolysates and an amino acid-derived formula in children with cow's milk allergy</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Caffarelli, C. ; Plebani, A. ; Poiesi, C. ; Petroccione, T. ; Spattini, A. ; Cavagni, G.</creator><creatorcontrib>Caffarelli, C. ; Plebani, A. ; Poiesi, C. ; Petroccione, T. ; Spattini, A. ; Cavagni, G.</creatorcontrib><description>Background Products based on hydrolysed cow milk proteins or amino acid mixtures are recommended in children with cow's milk hypersensitivity. However, some children who are allergic to cow's milk and who clinically react to substitute milk formulas have been observed.
Objective To determine the tolerance and allergenicity of protein hydrolysate or amino acid‐derived formulas in children with IgE‐mediated cow's milk allergy.
Methods Twenty children with positive cow's milk challenges, positive skin prick tests and/or serum‐specific IgE antibodies to cow's milk were selected. Oral challenges, skin prick tests and serum‐specific IgE antibodies to extensively hydrolysed whey formula, partially hydrolysed whey formula, extensively hydrolysed casein formula and amino acid‐derived formula were performed.
Results Five out of 17 (5/17) children reacted to partially hydrolysed whey formula, (3/16) to extensively hydrolysed whey formula, (2/10) to amino acid‐derived formula, (1/16) to extensively hydrolysed casein formula. Only extensively hydrolysed casein formula was tolerated by at least 90% (with 95% confidence intervals) of children. Hydrolysates provoked early and delayed clinical reactions, amino acid mixtures only delayed reactions. Partially hydrolysed whey formula elicited a significantly higher number of positive skin prick test reactions than other formulas. Two children had specific IgE antibodies to extensively hydrolysed whey formula, one to partially hydrolysed whey formula, one to extensively hydrolysed casein formula and none to amino acid‐derived formula.
Conclusion In this study, none of the cow's milk substitutes has been found to be non‐allergenic. Our results suggest that in children with IgE‐mediated cow's milk allergy, the first ingestions of extensively hydrolysed cow's milk protein formulas require strict medical supervision because of immediate reactions. This is not the case for amino acid‐derived formula. Moreover, our data suggest that treatment of children allergic to cow's milk with cow's milk substitutes should be monitored for several days to document tolerance.</description><identifier>ISSN: 0954-7894</identifier><identifier>EISSN: 1365-2222</identifier><identifier>DOI: 10.1046/j.0022-0477.2001.01262.x</identifier><identifier>PMID: 12002741</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Science, Ltd</publisher><subject>Allergens - immunology ; Allergic diseases ; amino acid-based formula ; Amino Acids - analysis ; Animals ; Biological and medical sciences ; Child ; Child, Preschool ; children ; cow's milk allergy ; Female ; Humans ; hydrolysed protein formulas ; Immune Tolerance ; Immunoglobulin E - immunology ; Immunopathology ; Male ; Medical sciences ; Milk - chemistry ; Milk - immunology ; Milk Hypersensitivity - diagnosis ; Milk Hypersensitivity - immunology ; Milk Proteins ; Other localizations ; Protein Hydrolysates - immunology</subject><ispartof>Clinical and experimental allergy, 2002-01, Vol.32 (1), p.74-79</ispartof><rights>2002 INIST-CNRS</rights><rights>Copyright Blackwell Scientific Publications Ltd. Jan 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4522-94ca8dfc3f6aa50b2ff897ad43b7d9c1bc2376a43bde1e3d8b81ffde732ce1e3</citedby><cites>FETCH-LOGICAL-c4522-94ca8dfc3f6aa50b2ff897ad43b7d9c1bc2376a43bde1e3d8b81ffde732ce1e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1046%2Fj.0022-0477.2001.01262.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1046%2Fj.0022-0477.2001.01262.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27902,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=13778032$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12002741$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Caffarelli, C.</creatorcontrib><creatorcontrib>Plebani, A.</creatorcontrib><creatorcontrib>Poiesi, C.</creatorcontrib><creatorcontrib>Petroccione, T.</creatorcontrib><creatorcontrib>Spattini, A.</creatorcontrib><creatorcontrib>Cavagni, G.</creatorcontrib><title>Determination of allergenicity to three cow's milk hydrolysates and an amino acid-derived formula in children with cow's milk allergy</title><title>Clinical and experimental allergy</title><addtitle>Clin Exp Allergy</addtitle><description>Background Products based on hydrolysed cow milk proteins or amino acid mixtures are recommended in children with cow's milk hypersensitivity. However, some children who are allergic to cow's milk and who clinically react to substitute milk formulas have been observed.
Objective To determine the tolerance and allergenicity of protein hydrolysate or amino acid‐derived formulas in children with IgE‐mediated cow's milk allergy.
Methods Twenty children with positive cow's milk challenges, positive skin prick tests and/or serum‐specific IgE antibodies to cow's milk were selected. Oral challenges, skin prick tests and serum‐specific IgE antibodies to extensively hydrolysed whey formula, partially hydrolysed whey formula, extensively hydrolysed casein formula and amino acid‐derived formula were performed.
Results Five out of 17 (5/17) children reacted to partially hydrolysed whey formula, (3/16) to extensively hydrolysed whey formula, (2/10) to amino acid‐derived formula, (1/16) to extensively hydrolysed casein formula. Only extensively hydrolysed casein formula was tolerated by at least 90% (with 95% confidence intervals) of children. Hydrolysates provoked early and delayed clinical reactions, amino acid mixtures only delayed reactions. Partially hydrolysed whey formula elicited a significantly higher number of positive skin prick test reactions than other formulas. Two children had specific IgE antibodies to extensively hydrolysed whey formula, one to partially hydrolysed whey formula, one to extensively hydrolysed casein formula and none to amino acid‐derived formula.
Conclusion In this study, none of the cow's milk substitutes has been found to be non‐allergenic. Our results suggest that in children with IgE‐mediated cow's milk allergy, the first ingestions of extensively hydrolysed cow's milk protein formulas require strict medical supervision because of immediate reactions. This is not the case for amino acid‐derived formula. Moreover, our data suggest that treatment of children allergic to cow's milk with cow's milk substitutes should be monitored for several days to document tolerance.</description><subject>Allergens - immunology</subject><subject>Allergic diseases</subject><subject>amino acid-based formula</subject><subject>Amino Acids - analysis</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>children</subject><subject>cow's milk allergy</subject><subject>Female</subject><subject>Humans</subject><subject>hydrolysed protein formulas</subject><subject>Immune Tolerance</subject><subject>Immunoglobulin E - immunology</subject><subject>Immunopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Milk - chemistry</subject><subject>Milk - immunology</subject><subject>Milk Hypersensitivity - diagnosis</subject><subject>Milk Hypersensitivity - immunology</subject><subject>Milk Proteins</subject><subject>Other localizations</subject><subject>Protein Hydrolysates - immunology</subject><issn>0954-7894</issn><issn>1365-2222</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkcuO0zAYhSMEYsrAKyALCVil-JLEzoLFUIaCGAGLEUhsLNf-Td1x4hk7pc0D8N44tGIQG7Bk-aLvHPvoFAUieE5w1bzYzDGmtMQV53OKMZljQhs6398pZoQ1dUnzuFvMcFtXJRdtdVI8SGmDMWZ1K-4XJySLKK_IrPjxGgaInevV4EKPgkXKe4jfoHfaDSMaAhrWEQDpsHueUOf8FVqPJgY_JjVAQqo3eSKVLQJS2pnSQHTfwSAbYrf1Crke6bXzJkKPdm5Y_2l1eGx8WNyzyid4dFxPi8s355eLt-XFx-W7xdlFqas6520rrYSxmtlGqRqvqLWi5cpUbMVNq8lKU8YblY8GCDAjVoJYa4AzqqeL0-LZwfY6hpstpEF2LmnwXvUQtkly0jSCNfSfIBEVrnFNMvjkL3ATtrHPGSRpW9EyxkWGxAHSMaQUwcrr6DoVR0mwnPqUGzn1Kac-5dSn_NWn3Gfp46P_dtWBuRUeC8zA0yOgklbeRtVrl245xrnAbEr08sDtnIfxvz8gF-dn0y7ry4PepQH2v_UqXsmGM17LLx-Wsn3_ecm-klfyE_sJmq_MmQ</recordid><startdate>200201</startdate><enddate>200201</enddate><creator>Caffarelli, C.</creator><creator>Plebani, A.</creator><creator>Poiesi, C.</creator><creator>Petroccione, T.</creator><creator>Spattini, A.</creator><creator>Cavagni, G.</creator><general>Blackwell Science, Ltd</general><general>Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200201</creationdate><title>Determination of allergenicity to three cow's milk hydrolysates and an amino acid-derived formula in children with cow's milk allergy</title><author>Caffarelli, C. ; Plebani, A. ; Poiesi, C. ; Petroccione, T. ; Spattini, A. ; Cavagni, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4522-94ca8dfc3f6aa50b2ff897ad43b7d9c1bc2376a43bde1e3d8b81ffde732ce1e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Allergens - immunology</topic><topic>Allergic diseases</topic><topic>amino acid-based formula</topic><topic>Amino Acids - analysis</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>children</topic><topic>cow's milk allergy</topic><topic>Female</topic><topic>Humans</topic><topic>hydrolysed protein formulas</topic><topic>Immune Tolerance</topic><topic>Immunoglobulin E - immunology</topic><topic>Immunopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Milk - chemistry</topic><topic>Milk - immunology</topic><topic>Milk Hypersensitivity - diagnosis</topic><topic>Milk Hypersensitivity - immunology</topic><topic>Milk Proteins</topic><topic>Other localizations</topic><topic>Protein Hydrolysates - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caffarelli, C.</creatorcontrib><creatorcontrib>Plebani, A.</creatorcontrib><creatorcontrib>Poiesi, C.</creatorcontrib><creatorcontrib>Petroccione, T.</creatorcontrib><creatorcontrib>Spattini, A.</creatorcontrib><creatorcontrib>Cavagni, G.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical and experimental allergy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caffarelli, C.</au><au>Plebani, A.</au><au>Poiesi, C.</au><au>Petroccione, T.</au><au>Spattini, A.</au><au>Cavagni, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of allergenicity to three cow's milk hydrolysates and an amino acid-derived formula in children with cow's milk allergy</atitle><jtitle>Clinical and experimental allergy</jtitle><addtitle>Clin Exp Allergy</addtitle><date>2002-01</date><risdate>2002</risdate><volume>32</volume><issue>1</issue><spage>74</spage><epage>79</epage><pages>74-79</pages><issn>0954-7894</issn><eissn>1365-2222</eissn><abstract>Background Products based on hydrolysed cow milk proteins or amino acid mixtures are recommended in children with cow's milk hypersensitivity. However, some children who are allergic to cow's milk and who clinically react to substitute milk formulas have been observed.
Objective To determine the tolerance and allergenicity of protein hydrolysate or amino acid‐derived formulas in children with IgE‐mediated cow's milk allergy.
Methods Twenty children with positive cow's milk challenges, positive skin prick tests and/or serum‐specific IgE antibodies to cow's milk were selected. Oral challenges, skin prick tests and serum‐specific IgE antibodies to extensively hydrolysed whey formula, partially hydrolysed whey formula, extensively hydrolysed casein formula and amino acid‐derived formula were performed.
Results Five out of 17 (5/17) children reacted to partially hydrolysed whey formula, (3/16) to extensively hydrolysed whey formula, (2/10) to amino acid‐derived formula, (1/16) to extensively hydrolysed casein formula. Only extensively hydrolysed casein formula was tolerated by at least 90% (with 95% confidence intervals) of children. Hydrolysates provoked early and delayed clinical reactions, amino acid mixtures only delayed reactions. Partially hydrolysed whey formula elicited a significantly higher number of positive skin prick test reactions than other formulas. Two children had specific IgE antibodies to extensively hydrolysed whey formula, one to partially hydrolysed whey formula, one to extensively hydrolysed casein formula and none to amino acid‐derived formula.
Conclusion In this study, none of the cow's milk substitutes has been found to be non‐allergenic. Our results suggest that in children with IgE‐mediated cow's milk allergy, the first ingestions of extensively hydrolysed cow's milk protein formulas require strict medical supervision because of immediate reactions. This is not the case for amino acid‐derived formula. Moreover, our data suggest that treatment of children allergic to cow's milk with cow's milk substitutes should be monitored for several days to document tolerance.</abstract><cop>Oxford, UK</cop><pub>Blackwell Science, Ltd</pub><pmid>12002741</pmid><doi>10.1046/j.0022-0477.2001.01262.x</doi><tpages>6</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Allergens - immunology Allergic diseases amino acid-based formula Amino Acids - analysis Animals Biological and medical sciences Child Child, Preschool children cow's milk allergy Female Humans hydrolysed protein formulas Immune Tolerance Immunoglobulin E - immunology Immunopathology Male Medical sciences Milk - chemistry Milk - immunology Milk Hypersensitivity - diagnosis Milk Hypersensitivity - immunology Milk Proteins Other localizations Protein Hydrolysates - immunology |
| title | Determination of allergenicity to three cow's milk hydrolysates and an amino acid-derived formula in children with cow's milk allergy |
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