Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells

Geraniin, a form of tannin separated from geranium, causes cell death through induction of apoptosis; however, cell death characteristics for geraniin have not yet been elucidated. Here, we investigated the mechanism of geraniin-induced apoptosis in human melanoma cells and demonstrated that geranii...

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Veröffentlicht in:	Molecular nutrition & food research 2008-06, Vol.52 (6), p.655-663
Hauptverfasser:	Lee, Jang-Chang, Tsai, Chih-Yen, Kao, Jung-Yie, Kao, Ming-Ching, Tsai, Shih-Chang, Chang, Chih-Shiang, Huang, Li-Jiau, Kuo, Sheng-Chu, Lin, Jen-Kun, Way, Tzong-Der
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticarcinogenic Agents - pharmacology Apoptosis Apoptosis - drug effects BH3 Interacting Domain Death Agonist Protein - metabolism Biological and medical sciences Caspase 8 - metabolism Caspase Inhibitors Caspase-3 Cell Line, Tumor Cytochromes c - metabolism Enzyme Activation - drug effects Enzyme Inhibitors - pharmacology Fas ligand Fas Ligand Protein - genetics Focal adhesion kinase Focal Adhesion Protein-Tyrosine Kinases - metabolism Food industries Fundamental and applied biological sciences. Psychology Geraniin Glucosides - metabolism Glucosides - pharmacology Humans Hydrolyzable Tannins - metabolism Hydrolyzable Tannins - pharmacology Melanoma - metabolism Up-Regulation - drug effects
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