Pegfilgrastim; a neutrophil mediated granulocyte colony stimulating factor-expanding uses in cancer chemotherapy

Background: Currently G-CSFs such as filgrastim (Neupogen®, Amgen, Inc.) and pegfilgrastim (Neulasta®, Amgen, Inc.) are widely used to reduce chemotherapy-induced neutropenia. Pegfilgrastim is a novel recombinant human G-CSF and its unique neutrophil-mediated clearance allows it to be administered o...

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Veröffentlicht in:	Expert opinion on biological therapy 2008-07, Vol.8 (7), p.993-1001
Hauptverfasser:	Morishita, Mariko, Leonard, Robert C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals cancer chemotherapy Clinical Trials as Topic Dose-Response Relationship, Drug Drug Design Filgrastim G-CSF Granulocyte Colony-Stimulating Factor - therapeutic use Hematopoietic Stem Cell Mobilization - methods Humans Neoplasms - therapy neutropenia Neutropenia - metabolism Neutrophils - metabolism pegfilgrastim Placebos Polyethylene Glycols Quality of Life Randomized Controlled Trials as Topic Recombinant Proteins
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