Tissue engineering of oral dysplasia

Keratinocytes and fibroblasts isolated from dysplastic oral lesions were combined to provide a renewable source of epithelia. A dysplasia-scoring index was devised to compare the architectural and cytological features and used together with robust immunophenotyping to show that the engineered epithe...

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Veröffentlicht in:	The Journal of pathology 2008-07, Vol.215 (3), p.280-289
Hauptverfasser:	Gaballah, K, Costea, DE, Hills, A, Gollin, SM, Harrison, P, Partridge, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Culture Media, Conditioned dysplasia Electrophoresis, Polyacrylamide Gel Enzyme-Linked Immunosorbent Assay - methods epithelial-connective tissue interaction tissue engineering epithelial-mesenchymal interaction Fibroblasts - cytology Fibroblasts - pathology Humans Hyperplasia Immunohistochemistry Investigative techniques, diagnostic techniques (general aspects) Keratinocytes - cytology Keratinocytes - pathology Keratins - analysis Leukoplakia, Oral - pathology Leukoplakia, Oral - therapy Linear Models Medical sciences Mouth Mucosa - cytology Mouth Mucosa - pathology organotypic culture Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques pre-cancer Precancerous Conditions - pathology Tissue Engineering - methods
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