Vesicle pools and short-term synaptic depression: lessons from a large synapse

Depletion of a pool of readily releasable vesicles during repetitive presynaptic activity is a candidate mechanism for the induction of short-term synaptic depression. The large, calyx-type synaptic terminals in the brainstem auditory pathway, and especially the calyx of Held, offer unique possibili...

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Veröffentlicht in:	Trends in Neurosciences 2002-04, Vol.25 (4), p.206-212
Hauptverfasser:	Schneggenburger, Ralf, Sakaba, Takeshi, Neher, Erwin
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - physiology Animals auditory pathways Auditory Pathways - cytology Auditory Pathways - metabolism excitatory postsynaptic current Excitatory Postsynaptic Potentials - physiology Exocytosis - physiology glutamate receptors Humans Mental depression Models, Neurological Neural Inhibition - physiology Neurology Neurotransmitter Agents - metabolism Neurotransmitter Agents - secretion Presynaptic Terminals - metabolism Presynaptic Terminals - ultrastructure release probability Rhombencephalon - cytology Rhombencephalon - metabolism short-term synaptic plasticity synaptic transmission Synaptic Transmission - physiology Synaptic Vesicles - metabolism Synaptic Vesicles - ultrastructure vesicle fusion
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