Characterization of selective estrogen receptor modulator (SERM) activity in two triarylethylene oxybutyric acids

Previously we identified 4-[1-(4-hydroxyphenyl)-2-phenylbuten-1-yl]phenoxy- n-butyric acid (4HBA) and its des-hydroxy analog (BA) as potential selective estrogen receptor modulators (SERMs) in the ovariectomized (OVX) rat. The aim of the present study was to characterize comprehensively the effects...

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Veröffentlicht in:	Biochemical pharmacology 2002-04, Vol.63 (8), p.1517-1525
Hauptverfasser:	Rubin, Valeria N., Ruenitz, Peter C., Boyd, Jason L., Douglas Boudinot, F., Wiese, Thomas E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Biotransformation Butyrates - chemistry Butyrates - pharmacology Cholesterol Estrogen receptor Estrogens - metabolism Female Genital system. Reproduction Humans Medical sciences Molecular Mimicry Osteocalcin Ovariectomy Pharmacology. Drug treatments Raloxifene Rats Receptors, Estrogen - metabolism Selective Estrogen Receptor Modulators - chemistry Selective Estrogen Receptor Modulators - pharmacology SERM Tamoxifen Tumor Cells, Cultured
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