Immunoregulatory Activities of Lactoferrin in the Delayed Type Hypersensitivity in Mice are Mediated by a Receptor with Affinity to Mannose
The mannose receptor (MR) mediates clearance of pathogenic microorganisms and potentially harmful glycoproteins by recognition of the carbohydrate structures. This manuscript describes the significance of the MR in mediation of the lactoferrin (LF) effects in delayed type hypersensitivity (DTH) in m...
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| Veröffentlicht in: | Immunobiology (1979) 2002-03, Vol.205 (1), p.120-131 |
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| creator | Zimecki, Micha Kocięba, Maja Kruzel, Marian |
| description | The mannose receptor (MR) mediates clearance of pathogenic microorganisms and potentially harmful glycoproteins by recognition of the carbohydrate structures. This manuscript describes the significance of the MR in mediation of the lactoferrin (LF) effects in delayed type hypersensitivity (DTH) in mice. Here we demonstrate that the inhibitory effect of LF on the effector phase of DTH to sheep red blood cells (SRBC) was abolished by intraperitoneal (i.p.) pretreatment of mice with 50mg of methyl-a-D-mannopyranoside (MMan). Also, we report that the inhibition of the effector DTH response to ovalbumin (OVA) was reversed by MMan but not by D-galactose (Gal). MMan was found to reduce the adjuvant activity of LF given together with OVA, however, did not interfere with the upstimulatory effect of the complete Freund's adjuvant. Comparative studies between bovine and human lactoferrins (BLF and HLF), revealed that the adjuvant effect of BLF was stronger than that of HLF, nevertheless, both effects were inhibited by MMan. Thus, we postulate, that MR is a primary receptor for lactoferrin in mediation of its some immunotropic activities. |
| doi_str_mv | 10.1078/0171-2985-00115 |
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This manuscript describes the significance of the MR in mediation of the lactoferrin (LF) effects in delayed type hypersensitivity (DTH) in mice. Here we demonstrate that the inhibitory effect of LF on the effector phase of DTH to sheep red blood cells (SRBC) was abolished by intraperitoneal (i.p.) pretreatment of mice with 50mg of methyl-a-D-mannopyranoside (MMan). Also, we report that the inhibition of the effector DTH response to ovalbumin (OVA) was reversed by MMan but not by D-galactose (Gal). MMan was found to reduce the adjuvant activity of LF given together with OVA, however, did not interfere with the upstimulatory effect of the complete Freund's adjuvant. Comparative studies between bovine and human lactoferrins (BLF and HLF), revealed that the adjuvant effect of BLF was stronger than that of HLF, nevertheless, both effects were inhibited by MMan. Thus, we postulate, that MR is a primary receptor for lactoferrin in mediation of its some immunotropic activities.</description><identifier>ISSN: 0171-2985</identifier><identifier>EISSN: 1878-3279</identifier><identifier>DOI: 10.1078/0171-2985-00115</identifier><identifier>PMID: 11999341</identifier><language>eng</language><publisher>Netherlands: Elsevier GmbH</publisher><subject>Animals ; Cattle ; Dose-Response Relationship, Drug ; Female ; Humans ; Hypersensitivity, Delayed - immunology ; Lactoferrin - pharmacology ; Lectins, C-Type ; Male ; Mannose-Binding Lectins ; Mannosides - pharmacology ; Methylmannosides ; Mice ; Mice, Inbred CBA ; Receptors, Cell Surface - immunology</subject><ispartof>Immunobiology (1979), 2002-03, Vol.205 (1), p.120-131</ispartof><rights>2002 Urban & Fischer Verlag</rights><rights>Copyright Urban & Fischer Verlag Mar 2002</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-e41577db1223c32946a980aa7cc54b34673cd36adf8e9a8f1c209069420b6aed3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/214018509?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>315,781,785,3551,27925,27926,45996,64386,64388,64390,72470</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/11999341$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zimecki, Micha</creatorcontrib><creatorcontrib>Kocięba, Maja</creatorcontrib><creatorcontrib>Kruzel, Marian</creatorcontrib><title>Immunoregulatory Activities of Lactoferrin in the Delayed Type Hypersensitivity in Mice are Mediated by a Receptor with Affinity to Mannose</title><title>Immunobiology (1979)</title><addtitle>Immunobiology</addtitle><description>The mannose receptor (MR) mediates clearance of pathogenic microorganisms and potentially harmful glycoproteins by recognition of the carbohydrate structures. This manuscript describes the significance of the MR in mediation of the lactoferrin (LF) effects in delayed type hypersensitivity (DTH) in mice. Here we demonstrate that the inhibitory effect of LF on the effector phase of DTH to sheep red blood cells (SRBC) was abolished by intraperitoneal (i.p.) pretreatment of mice with 50mg of methyl-a-D-mannopyranoside (MMan). Also, we report that the inhibition of the effector DTH response to ovalbumin (OVA) was reversed by MMan but not by D-galactose (Gal). MMan was found to reduce the adjuvant activity of LF given together with OVA, however, did not interfere with the upstimulatory effect of the complete Freund's adjuvant. Comparative studies between bovine and human lactoferrins (BLF and HLF), revealed that the adjuvant effect of BLF was stronger than that of HLF, nevertheless, both effects were inhibited by MMan. Thus, we postulate, that MR is a primary receptor for lactoferrin in mediation of its some immunotropic activities.</description><subject>Animals</subject><subject>Cattle</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Humans</subject><subject>Hypersensitivity, Delayed - immunology</subject><subject>Lactoferrin - pharmacology</subject><subject>Lectins, C-Type</subject><subject>Male</subject><subject>Mannose-Binding Lectins</subject><subject>Mannosides - pharmacology</subject><subject>Methylmannosides</subject><subject>Mice</subject><subject>Mice, Inbred CBA</subject><subject>Receptors, Cell Surface - immunology</subject><issn>0171-2985</issn><issn>1878-3279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqFkU9rFTEUxYMo9lldu5Pgwt3Y3PmXZPlo1RbeQ5C6DpnMHZsykzyTTGU-g1_aTN9DQRAhJIv8zrnJOYS8BvYeGBcXDDgUpRRNwRhA84RsQHBRVCWXT8nm9-0ZeRHjfUZkycVzcgYgpaxq2JCfN9M0Ox_w2zzq5MNCtybZB5ssRuoHutMm-QFDsI7mle6QXuGoF-zp7XJAep23ENFF-6haVmhvDVIdkO6xtzpltFuopl_Q4CGPoD9suqPbYbBuFSRP99o5H_EleTboMeKr03lOvn78cHt5Xew-f7q53O4KUzNIBdbQcN53UJaVqUpZt1oKpjU3pqm7qm55Zfqq1f0gUGoxgCmZZK2sS9a1GvvqnLw7-h6C_z5jTGqy0eA4aod-jopD2-bU4L8giErybJ3Bt3-B934OLn9ClZAfLRomM3RxhEzwMQYc1CHYSYdFAVNrm2rtS619qcc2s-LNyXbuJuz_8Kf6MiCPAOa4HiwGFY1FZ3LuAU1Svbf_NP8FkXmtTw</recordid><startdate>20020301</startdate><enddate>20020301</enddate><creator>Zimecki, Micha</creator><creator>Kocięba, Maja</creator><creator>Kruzel, Marian</creator><general>Elsevier GmbH</general><general>Elsevier Science Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>S0X</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>20020301</creationdate><title>Immunoregulatory Activities of Lactoferrin in the Delayed Type Hypersensitivity in Mice are Mediated by a Receptor with Affinity to Mannose</title><author>Zimecki, Micha ; Kocięba, Maja ; Kruzel, Marian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-e41577db1223c32946a980aa7cc54b34673cd36adf8e9a8f1c209069420b6aed3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2002</creationdate><topic>Animals</topic><topic>Cattle</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Humans</topic><topic>Hypersensitivity, Delayed - immunology</topic><topic>Lactoferrin - pharmacology</topic><topic>Lectins, C-Type</topic><topic>Male</topic><topic>Mannose-Binding Lectins</topic><topic>Mannosides - pharmacology</topic><topic>Methylmannosides</topic><topic>Mice</topic><topic>Mice, Inbred CBA</topic><topic>Receptors, Cell Surface - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zimecki, Micha</creatorcontrib><creatorcontrib>Kocięba, Maja</creatorcontrib><creatorcontrib>Kruzel, Marian</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Immunobiology (1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zimecki, Micha</au><au>Kocięba, Maja</au><au>Kruzel, Marian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoregulatory Activities of Lactoferrin in the Delayed Type Hypersensitivity in Mice are Mediated by a Receptor with Affinity to Mannose</atitle><jtitle>Immunobiology (1979)</jtitle><addtitle>Immunobiology</addtitle><date>2002-03-01</date><risdate>2002</risdate><volume>205</volume><issue>1</issue><spage>120</spage><epage>131</epage><pages>120-131</pages><issn>0171-2985</issn><eissn>1878-3279</eissn><abstract>The mannose receptor (MR) mediates clearance of pathogenic microorganisms and potentially harmful glycoproteins by recognition of the carbohydrate structures. This manuscript describes the significance of the MR in mediation of the lactoferrin (LF) effects in delayed type hypersensitivity (DTH) in mice. Here we demonstrate that the inhibitory effect of LF on the effector phase of DTH to sheep red blood cells (SRBC) was abolished by intraperitoneal (i.p.) pretreatment of mice with 50mg of methyl-a-D-mannopyranoside (MMan). Also, we report that the inhibition of the effector DTH response to ovalbumin (OVA) was reversed by MMan but not by D-galactose (Gal). MMan was found to reduce the adjuvant activity of LF given together with OVA, however, did not interfere with the upstimulatory effect of the complete Freund's adjuvant. Comparative studies between bovine and human lactoferrins (BLF and HLF), revealed that the adjuvant effect of BLF was stronger than that of HLF, nevertheless, both effects were inhibited by MMan. Thus, we postulate, that MR is a primary receptor for lactoferrin in mediation of its some immunotropic activities.</abstract><cop>Netherlands</cop><pub>Elsevier GmbH</pub><pmid>11999341</pmid><doi>10.1078/0171-2985-00115</doi><tpages>12</tpages></addata></record> |
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| subjects | Animals Cattle Dose-Response Relationship, Drug Female Humans Hypersensitivity, Delayed - immunology Lactoferrin - pharmacology Lectins, C-Type Male Mannose-Binding Lectins Mannosides - pharmacology Methylmannosides Mice Mice, Inbred CBA Receptors, Cell Surface - immunology |
| title | Immunoregulatory Activities of Lactoferrin in the Delayed Type Hypersensitivity in Mice are Mediated by a Receptor with Affinity to Mannose |
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