Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study
Aims We explored gender differences in the association of high‐sensitivity C‐reactive protein (hs‐CRP), interleukin‐1 receptor antagonist (IL‐1Ra) and adiponectin with the metabolic syndrome (MetS) defined by the National Cholesterol Education Program (NCEP) and the International Diabetes Federatio...
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| Veröffentlicht in: | Diabetic medicine 2008-06, Vol.25 (6), p.747-750 |
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| container_title | Diabetic medicine |
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| creator | Saltevo, J. Vanhala, M. Kautiainen, H. Kumpusalo, E. Laakso, M. |
| description | Aims We explored gender differences in the association of high‐sensitivity C‐reactive protein (hs‐CRP), interleukin‐1 receptor antagonist (IL‐1Ra) and adiponectin with the metabolic syndrome (MetS) defined by the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) criteria.
Methods A population‐based study of 923 middle‐aged subjects in Pieksämäki, East Finland.
Results The prevalence of the MetS according to the IDF and NCEP definitions was 38% and 34% in men (N = 405) and 34% and 27% in women (N = 497), respectively. hs‐CRP and IL‐1Ra levels were higher in subjects with the MetS compared with those without the MetS in both sexes (P |
| doi_str_mv | 10.1111/j.1464-5491.2008.02440.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_71662587</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>20878792</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5320-a48d0031f52d294f7dcb523ac64fabbf543e496b89c85becb7f657fd8751fddd3</originalsourceid><addsrcrecordid>eNqNkUGP1CAUxxujccfVr2C46MmOQKFQEw9m3B1N1vWgRm-EwkOZ7dAKdJ35In5e253JeFQuvMDv_x7kVxSI4CWZ1svNkrCalZw1ZEkxlktMGcPL3b1icbq4XyywYLSssCBnxaOUNhgT2lTNw-KMSFZxIfGi-L2GYCEi652DCMFAQj6gVRlBm-xvAQ2xz-DDi-k4Q-xgvPGhJCiCgSH3EemQ9fc--JSn0iJt_dAHmLIBdXAL3V2__APQFrJu-84blPbBxn4Lr5BGQz-Mnc6-D2WrE1iU8mj3j4sHTncJnhz38-LL5cXn1bvy6uP6_erNVWl4RXGpmbQYV8RxamnDnLCm5bTSpmZOt63jrALW1K1sjOQtmFa4mgtnpeDEWWur8-L5oe_0y58jpKy2PhnoOh2gH5MSpK4pl-KfIMVSSNHQCZQH0MQ-pQhODdFvddwrgtUsT23U7EjNjtQsT93JU7sp-vQ4Y2y3YP8Gj7Ym4NkR0MnozkUdjE8njmKGecNn7vWB--U72P_3A9TbDxdzNeXLQ36SCrtTXscbVYtKcPX1eq0u5beq-XRNVF39ASo9x5g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20878792</pqid></control><display><type>article</type><title>Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study</title><source>MEDLINE</source><source>Wiley Online Library All Journals</source><creator>Saltevo, J. ; Vanhala, M. ; Kautiainen, H. ; Kumpusalo, E. ; Laakso, M.</creator><creatorcontrib>Saltevo, J. ; Vanhala, M. ; Kautiainen, H. ; Kumpusalo, E. ; Laakso, M.</creatorcontrib><description>Aims We explored gender differences in the association of high‐sensitivity C‐reactive protein (hs‐CRP), interleukin‐1 receptor antagonist (IL‐1Ra) and adiponectin with the metabolic syndrome (MetS) defined by the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) criteria.
Methods A population‐based study of 923 middle‐aged subjects in Pieksämäki, East Finland.
Results The prevalence of the MetS according to the IDF and NCEP definitions was 38% and 34% in men (N = 405) and 34% and 27% in women (N = 497), respectively. hs‐CRP and IL‐1Ra levels were higher in subjects with the MetS compared with those without the MetS in both sexes (P < 0.001). The levels of hs‐CRP (P < 0.001) and IL‐1Ra (P = 0.0016 for NCEP criteria, P = 0.0028 for IDF criteria) were significantly higher in women with MetS than in men with MetS. In contrast, in subjects without MetS, no gender differences in the levels of hs‐CRP or IL‐1Ra were found.
Conclusion Women with MetS, defined by the IDF or NCEP criteria, had higher levels of hs‐CRP and IL‐1Ra than did men with MetS. Thus, low‐grade inflammation may contribute to the high risk of cardiovascular disease in women with MetS.</description><identifier>ISSN: 0742-3071</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/j.1464-5491.2008.02440.x</identifier><identifier>PMID: 18435780</identifier><identifier>CODEN: DIMEEV</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>adiponectin ; Adiponectin - metabolism ; Adult ; Biological and medical sciences ; Biomarkers - metabolism ; C-reactive protein ; C-Reactive Protein - metabolism ; Diabetic Angiopathies - prevention & control ; Endocrinopathies ; Feeding. Feeding behavior ; Female ; Finland - epidemiology ; Fundamental and applied biological sciences. Psychology ; gender difference ; Humans ; Interleukin 1 Receptor Antagonist Protein ; interleukin-1 receptor antagonist ; Male ; Medical sciences ; metabolic syndrome ; Metabolic Syndrome - epidemiology ; Metabolic Syndrome - metabolism ; Middle Aged ; Obesity - complications ; Risk Factors ; Sex Factors ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology</subject><ispartof>Diabetic medicine, 2008-06, Vol.25 (6), p.747-750</ispartof><rights>2008 The Authors. Journal compilation © 2008 Diabetes UK</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5320-a48d0031f52d294f7dcb523ac64fabbf543e496b89c85becb7f657fd8751fddd3</citedby><cites>FETCH-LOGICAL-c5320-a48d0031f52d294f7dcb523ac64fabbf543e496b89c85becb7f657fd8751fddd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1464-5491.2008.02440.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1464-5491.2008.02440.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20405950$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18435780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saltevo, J.</creatorcontrib><creatorcontrib>Vanhala, M.</creatorcontrib><creatorcontrib>Kautiainen, H.</creatorcontrib><creatorcontrib>Kumpusalo, E.</creatorcontrib><creatorcontrib>Laakso, M.</creatorcontrib><title>Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>Aims We explored gender differences in the association of high‐sensitivity C‐reactive protein (hs‐CRP), interleukin‐1 receptor antagonist (IL‐1Ra) and adiponectin with the metabolic syndrome (MetS) defined by the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) criteria.
Methods A population‐based study of 923 middle‐aged subjects in Pieksämäki, East Finland.
Results The prevalence of the MetS according to the IDF and NCEP definitions was 38% and 34% in men (N = 405) and 34% and 27% in women (N = 497), respectively. hs‐CRP and IL‐1Ra levels were higher in subjects with the MetS compared with those without the MetS in both sexes (P < 0.001). The levels of hs‐CRP (P < 0.001) and IL‐1Ra (P = 0.0016 for NCEP criteria, P = 0.0028 for IDF criteria) were significantly higher in women with MetS than in men with MetS. In contrast, in subjects without MetS, no gender differences in the levels of hs‐CRP or IL‐1Ra were found.
Conclusion Women with MetS, defined by the IDF or NCEP criteria, had higher levels of hs‐CRP and IL‐1Ra than did men with MetS. Thus, low‐grade inflammation may contribute to the high risk of cardiovascular disease in women with MetS.</description><subject>adiponectin</subject><subject>Adiponectin - metabolism</subject><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>C-reactive protein</subject><subject>C-Reactive Protein - metabolism</subject><subject>Diabetic Angiopathies - prevention & control</subject><subject>Endocrinopathies</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Finland - epidemiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>gender difference</subject><subject>Humans</subject><subject>Interleukin 1 Receptor Antagonist Protein</subject><subject>interleukin-1 receptor antagonist</subject><subject>Male</subject><subject>Medical sciences</subject><subject>metabolic syndrome</subject><subject>Metabolic Syndrome - epidemiology</subject><subject>Metabolic Syndrome - metabolism</subject><subject>Middle Aged</subject><subject>Obesity - complications</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vertebrates: endocrinology</subject><issn>0742-3071</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUGP1CAUxxujccfVr2C46MmOQKFQEw9m3B1N1vWgRm-EwkOZ7dAKdJ35In5e253JeFQuvMDv_x7kVxSI4CWZ1svNkrCalZw1ZEkxlktMGcPL3b1icbq4XyywYLSssCBnxaOUNhgT2lTNw-KMSFZxIfGi-L2GYCEi652DCMFAQj6gVRlBm-xvAQ2xz-DDi-k4Q-xgvPGhJCiCgSH3EemQ9fc--JSn0iJt_dAHmLIBdXAL3V2__APQFrJu-84blPbBxn4Lr5BGQz-Mnc6-D2WrE1iU8mj3j4sHTncJnhz38-LL5cXn1bvy6uP6_erNVWl4RXGpmbQYV8RxamnDnLCm5bTSpmZOt63jrALW1K1sjOQtmFa4mgtnpeDEWWur8-L5oe_0y58jpKy2PhnoOh2gH5MSpK4pl-KfIMVSSNHQCZQH0MQ-pQhODdFvddwrgtUsT23U7EjNjtQsT93JU7sp-vQ4Y2y3YP8Gj7Ym4NkR0MnozkUdjE8njmKGecNn7vWB--U72P_3A9TbDxdzNeXLQ36SCrtTXscbVYtKcPX1eq0u5beq-XRNVF39ASo9x5g</recordid><startdate>200806</startdate><enddate>200806</enddate><creator>Saltevo, J.</creator><creator>Vanhala, M.</creator><creator>Kautiainen, H.</creator><creator>Kumpusalo, E.</creator><creator>Laakso, M.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200806</creationdate><title>Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study</title><author>Saltevo, J. ; Vanhala, M. ; Kautiainen, H. ; Kumpusalo, E. ; Laakso, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5320-a48d0031f52d294f7dcb523ac64fabbf543e496b89c85becb7f657fd8751fddd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>adiponectin</topic><topic>Adiponectin - metabolism</topic><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>C-reactive protein</topic><topic>C-Reactive Protein - metabolism</topic><topic>Diabetic Angiopathies - prevention & control</topic><topic>Endocrinopathies</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Finland - epidemiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>gender difference</topic><topic>Humans</topic><topic>Interleukin 1 Receptor Antagonist Protein</topic><topic>interleukin-1 receptor antagonist</topic><topic>Male</topic><topic>Medical sciences</topic><topic>metabolic syndrome</topic><topic>Metabolic Syndrome - epidemiology</topic><topic>Metabolic Syndrome - metabolism</topic><topic>Middle Aged</topic><topic>Obesity - complications</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vertebrates: endocrinology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saltevo, J.</creatorcontrib><creatorcontrib>Vanhala, M.</creatorcontrib><creatorcontrib>Kautiainen, H.</creatorcontrib><creatorcontrib>Kumpusalo, E.</creatorcontrib><creatorcontrib>Laakso, M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saltevo, J.</au><au>Vanhala, M.</au><au>Kautiainen, H.</au><au>Kumpusalo, E.</au><au>Laakso, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2008-06</date><risdate>2008</risdate><volume>25</volume><issue>6</issue><spage>747</spage><epage>750</epage><pages>747-750</pages><issn>0742-3071</issn><eissn>1464-5491</eissn><coden>DIMEEV</coden><abstract>Aims We explored gender differences in the association of high‐sensitivity C‐reactive protein (hs‐CRP), interleukin‐1 receptor antagonist (IL‐1Ra) and adiponectin with the metabolic syndrome (MetS) defined by the National Cholesterol Education Program (NCEP) and the International Diabetes Federation (IDF) criteria.
Methods A population‐based study of 923 middle‐aged subjects in Pieksämäki, East Finland.
Results The prevalence of the MetS according to the IDF and NCEP definitions was 38% and 34% in men (N = 405) and 34% and 27% in women (N = 497), respectively. hs‐CRP and IL‐1Ra levels were higher in subjects with the MetS compared with those without the MetS in both sexes (P < 0.001). The levels of hs‐CRP (P < 0.001) and IL‐1Ra (P = 0.0016 for NCEP criteria, P = 0.0028 for IDF criteria) were significantly higher in women with MetS than in men with MetS. In contrast, in subjects without MetS, no gender differences in the levels of hs‐CRP or IL‐1Ra were found.
Conclusion Women with MetS, defined by the IDF or NCEP criteria, had higher levels of hs‐CRP and IL‐1Ra than did men with MetS. Thus, low‐grade inflammation may contribute to the high risk of cardiovascular disease in women with MetS.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18435780</pmid><doi>10.1111/j.1464-5491.2008.02440.x</doi><tpages>4</tpages></addata></record> |
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| ispartof | Diabetic medicine, 2008-06, Vol.25 (6), p.747-750 |
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| subjects | adiponectin Adiponectin - metabolism Adult Biological and medical sciences Biomarkers - metabolism C-reactive protein C-Reactive Protein - metabolism Diabetic Angiopathies - prevention & control Endocrinopathies Feeding. Feeding behavior Female Finland - epidemiology Fundamental and applied biological sciences. Psychology gender difference Humans Interleukin 1 Receptor Antagonist Protein interleukin-1 receptor antagonist Male Medical sciences metabolic syndrome Metabolic Syndrome - epidemiology Metabolic Syndrome - metabolism Middle Aged Obesity - complications Risk Factors Sex Factors Vertebrates: anatomy and physiology, studies on body, several organs or systems Vertebrates: endocrinology |
| title | Gender differences in C-reactive protein, interleukin-1 receptor antagonist and adiponectin levels in the metabolic syndrome: a population-based study |
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