Effects of quantity and quality of dietary protein on the brain polysome profile in aged rats
The purpose of this study was to determine whether the quantity and quality of dietary protein affected the polysome profile of the brain in aged rats. Two experiments were done on three groups of aged rats (30 wk) given the diets containing 20% casein, 5% casein, or 0% casein (experiment 1), and 20...
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Veröffentlicht in: | Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2002-02, Vol.66 (2), p.351-355 |
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creator | Hirano, E. (Aichi Univ. of Education, Kariya (Japan)) Lyou, S Tujioka, K Tanaka, M Hayase, K Okuyama, S Yokogoshi, H |
description | The purpose of this study was to determine whether the quantity and quality of dietary protein affected the polysome profile of the brain in aged rats. Two experiments were done on three groups of aged rats (30 wk) given the diets containing 20% casein, 5% casein, or 0% casein (experiment 1), and 20% casein, 20% gluten, or 20% gelatin (experiment 2) for 10 d. The aggregation in brain ribosomes declined with a decrease of quantity and quality of dietary protein except in the hippocampus. The RNA concentration (mg RNA/g protein) did not differ among the three groups varying the dietary protein in any brain regions. The results suggest that the higher quantity and quality of dietary protein improves the polysome profile in the brain of aged rats, and that the polysome profile is at least partly related to the mechanism by which the dietary protein affects brain protein synthesis in aged rats. |
doi_str_mv | 10.1271/bbb.66.351 |
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The results suggest that the higher quantity and quality of dietary protein improves the polysome profile in the brain of aged rats, and that the polysome profile is at least partly related to the mechanism by which the dietary protein affects brain protein synthesis in aged rats.</description><identifier>ISSN: 0916-8451</identifier><identifier>EISSN: 1347-6947</identifier><identifier>DOI: 10.1271/bbb.66.351</identifier><identifier>PMID: 11999408</identifier><language>eng</language><publisher>Tokyo: Japan Society for Bioscience Biotechnology and Agrochemistry</publisher><subject>Animals ; Biochemistry and metabolism ; Biological and medical sciences ; BRAIN ; Brain - metabolism ; Central nervous system ; DIET ; Dietary Proteins - administration & dosage ; Dietary Proteins - classification ; Dietary Proteins - standards ; ELDERLY ; FEEDING LEVEL ; Fundamental and applied biological sciences. 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The aggregation in brain ribosomes declined with a decrease of quantity and quality of dietary protein except in the hippocampus. The RNA concentration (mg RNA/g protein) did not differ among the three groups varying the dietary protein in any brain regions. 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Psychology</subject><subject>Male</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Polyribosomes - metabolism</subject><subject>PROTEINS</subject><subject>QUALITY</subject><subject>RATS</subject><subject>Rats, Wistar</subject><subject>RIBOSOMES</subject><subject>RNA - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0916-8451</issn><issn>1347-6947</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2002</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpF0EtLAzEQB_Agiq3Vi3clF71t3WzeRyn1RUEPepRlsknqyj7qJnvotzelFSGQzD8_hkkQuiT5nBSS3Blj5kLMKSdHaEook5nQTB6jaa6JyBTjZILOQvjO8xRwcoomhGitWa6m6HPpvatiwL3HPyN0sY5bDJ3dFc3unHJbuwjDFm-GPrq6w32H45fDZoBUbPpmG_rW7W593TicMlg7iweI4RydeGiCuzjsM_TxsHxfPGWr18fnxf0q81SymFFhvC4sc4QZZqjy3vA0oq2UEeCU0pQYAsCNYh6EFEpSp6RVnnqeBNAZut33TUP8jC7Esq1D5ZoGOtePoZREiIIqnuD1AY6mdbbcDHWbnlb-fUgCNwcAoYLGD9BVdfh3VAiiCprc1d556EtYD8m8vBV5nhbVXNFfGOl4QA</recordid><startdate>20020201</startdate><enddate>20020201</enddate><creator>Hirano, E. 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subjects | Animals Biochemistry and metabolism Biological and medical sciences BRAIN Brain - metabolism Central nervous system DIET Dietary Proteins - administration & dosage Dietary Proteins - classification Dietary Proteins - standards ELDERLY FEEDING LEVEL Fundamental and applied biological sciences. Psychology Male Nerve Tissue Proteins - metabolism Polyribosomes - metabolism PROTEINS QUALITY RATS Rats, Wistar RIBOSOMES RNA - metabolism Vertebrates: nervous system and sense organs |
title | Effects of quantity and quality of dietary protein on the brain polysome profile in aged rats |
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