Effects of quantity and quality of dietary protein on the brain polysome profile in aged rats

The purpose of this study was to determine whether the quantity and quality of dietary protein affected the polysome profile of the brain in aged rats. Two experiments were done on three groups of aged rats (30 wk) given the diets containing 20% casein, 5% casein, or 0% casein (experiment 1), and 20...

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Veröffentlicht in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2002-02, Vol.66 (2), p.351-355
Hauptverfasser: Hirano, E. (Aichi Univ. of Education, Kariya (Japan)), Lyou, S, Tujioka, K, Tanaka, M, Hayase, K, Okuyama, S, Yokogoshi, H
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container_end_page 355
container_issue 2
container_start_page 351
container_title Bioscience, biotechnology, and biochemistry
container_volume 66
creator Hirano, E. (Aichi Univ. of Education, Kariya (Japan))
Lyou, S
Tujioka, K
Tanaka, M
Hayase, K
Okuyama, S
Yokogoshi, H
description The purpose of this study was to determine whether the quantity and quality of dietary protein affected the polysome profile of the brain in aged rats. Two experiments were done on three groups of aged rats (30 wk) given the diets containing 20% casein, 5% casein, or 0% casein (experiment 1), and 20% casein, 20% gluten, or 20% gelatin (experiment 2) for 10 d. The aggregation in brain ribosomes declined with a decrease of quantity and quality of dietary protein except in the hippocampus. The RNA concentration (mg RNA/g protein) did not differ among the three groups varying the dietary protein in any brain regions. The results suggest that the higher quantity and quality of dietary protein improves the polysome profile in the brain of aged rats, and that the polysome profile is at least partly related to the mechanism by which the dietary protein affects brain protein synthesis in aged rats.
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source MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Oxford University Press Journals All Titles (1996-Current); J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Open Access Titles of Japan; Free Full-Text Journals in Chemistry
subjects Animals
Biochemistry and metabolism
Biological and medical sciences
BRAIN
Brain - metabolism
Central nervous system
DIET
Dietary Proteins - administration & dosage
Dietary Proteins - classification
Dietary Proteins - standards
ELDERLY
FEEDING LEVEL
Fundamental and applied biological sciences. Psychology
Male
Nerve Tissue Proteins - metabolism
Polyribosomes - metabolism
PROTEINS
QUALITY
RATS
Rats, Wistar
RIBOSOMES
RNA - metabolism
Vertebrates: nervous system and sense organs
title Effects of quantity and quality of dietary protein on the brain polysome profile in aged rats
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